Signaling Pathway News and Research

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Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Understanding how cancer cells are able to metastasize -- migrate from the primary tumor to distant sites in the body -- and developing therapies to inhibit this process are the focus of many laboratories around the country.

18 Dec 2017

Study reveals novel molecular targets to improve chemotherapy’s efficiency against leukemia

Researchers from Instituto de Medicina Molecular João Lobo Antunes have found a mechanism through which certain types of leukemia resist chemotherapy, thus revealing novel molecular targets that may be used to improve the efficiency of this type of treatment.

12 Dec 2017

Researchers reveal pathological mechanisms in congenital myotonic dystrophy

Myotonic dystrophy (DM) is the most common form of genetic muscular dystrophy that begins in adulthood. DM is characterized by progressive muscle wasting and weakness. People with this disorder often have prolonged muscle contractions (myotonic) and are not able to relax certain muscles after use.

12 Dec 2017

Study identifies new role for stress receptor CRF1 expressed on mast cells

A new study published online in the Journal of Leukocyte Biology provides new insight into how stress, through signaling of corticotropin-releasing factor (CRF), interacts with cells in the immune system to cause disease.

1 Dec 2017

Study identifies signaling pathway essential for growth of new blood vessels

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels.

23 Nov 2017

Separating side effects could pave way for safe, effective pain medications

Opioid pain relievers can be extremely effective in relieving pain, but can carry a high risk of addiction and ultimately overdose when breathing is suppressed and stops.

16 Nov 2017

Anti-parasite drug acts like tailored medicine against colon, prostate cancer

Medicine against parasites like Tapeworms and Giardia, contains a substance that kills Prostate- and colon cancer.

14 Nov 2017

Scientists uncover previously unknown mechanism to combat influenza A virus

Just as flu season swings into full gear, researchers from the University of Colorado Boulder and University of Texas at Austin have uncovered a previously unknown mechanism by which the human immune system tries to battle the influenza A virus.

8 Nov 2017

Researchers discover mechanism that corrects protein misfolding in plants

Various human nervous system diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer's, Huntington's, and Parkinson's diseases, are associated with the same basic disorder: the loss of nerve cells capacity to fold their proteins correctly, which causes protein aggregations that form "clumps" that end up generating the cell death.

25 Oct 2017

Study elucidates how obesity makes breast cancer more aggressive

Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result. Scientists from Helmholtz Zentrum München, Technische Universität München, and Heidelberg University Hospital report on this in 'Cell Metabolism'. The team has already been able to halt this mechanism with an antibody treatment.

23 Oct 2017

Study sheds new light on why autism is more common in boys

Researchers aiming to understand why autism spectrum disorders (ASD) are more common in boys have discovered differences in a brain signaling pathway involved in reward learning and motivation that make male mice more vulnerable to an autism-causing genetic glitch.

17 Oct 2017

Scientists discover new non-genetic cause of resistance to anti-cancer therapies

The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States.

16 Oct 2017

Study sheds light on the mechanism of lung damage in premature babies

The lungs are one of the last organs to undergo full maturation in a baby's body. Children that are born very prematurely do not have fully developed lungs, and are therefore more susceptible to associated complications.

30 Sep 2017

Researchers test way to stop or slow cardiac fibrosis after heart injury

Early research results suggest scientists might be on to a way to preserve heart function after heart attacks or for people with inherited heart defects called congenital cardiomyopathies.

28 Sep 2017

Drug combination produces synergistic effect against growth of triple-negative breast cancer

In the hunt for novel treatments against an aggressive form of breast cancer, researchers combined a new protein inhibitor with a chemotherapy drug to create a powerful combination that resulted in cancer cell death.

26 Sep 2017

UAB researchers detail underlying mechanism leading to age-associated osteoporosis

A major health problem in older people is age-associated osteoporosis -- the thinning of bone and the loss of bone density that increases the risk of fractures. Often this is accompanied by an increase in fat cells in the bone marrow.

22 Sep 2017

Researchers identify molecular pathway that causes immune cells to promote cancer

Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles have identified new findings about an immune cell - called a tumor-associated macrophage - that promotes cancer instead of fighting it.

21 Sep 2017

Houston Methodist researchers find pathway for treating diseases caused by flesh-eating bacteria

Researchers at Houston Methodist have solved a 100-year-old mystery, providing them a possible key to unlock a pathway for treating diseases caused by flesh-eating bacteria. This is timely news, given the current dangers lurking in the debris and destruction left behind by Hurricane Harvey's floodwaters that destroyed tens of thousands of homes in Texas.

19 Sep 2017

EPFL scientists discover metabolic differences between hepatoblastoma subtypes

Hepatoblastoma is a rare pediatric liver cancer, usually diagnosed in the first three years of life. Histological methods are used to distinguish between the different subtypes of hepatoblastoma.

18 Sep 2017

Heidelberg researchers gain new insights into formation of blood vessels

New insights into the development of the vascular system: researchers in the team of Dr Carmen Ruiz de Almodóvar of the Heidelberg University Biochemistry Center have discovered a crucial biological step that regulates the formation of blood vessels.

15 Sep 2017