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Researchers identify specific genes linked to increased risk for triple-negative breast cancer

A research team led by Fergus Couch, Ph.D., a geneticist at Mayo Clinic, has identified specific genes associated with an increased risk for developing triple-negative breast cancer. Their research was published in the Journal of the National Cancer Institute.

7 Aug 2018

Inhibition of NOVA1 gene helps prevent growth of lung cancer tumors

Researchers have identified a gene that when inhibited or reduced, in turn, reduced or prevented human non-small cell lung cancer tumors from growing.

7 Aug 2018

Unique experimental vaccine against Zika virus proves powerful in mice

A uniquely designed experimental vaccine against Zika virus has proven powerful in mice, new research has found.

6 Aug 2018

Researchers identify new regulator in breast cancer cells

Triple-negative breast cancer is a particularly aggressive form of breast cancer. Here, important receptors are missing, which often serve as targets for treatments.

6 Aug 2018

Research highlights how heritable and environmental factors can influence epigenetic variations

New research highlights the extent to which epigenetic variation is influenced by both inherited and environmental factors.

3 Aug 2018

Study highlights impact of silent viruses on how the host responds to vaccines

UC Davis researchers have shown that low levels of cytomegalovirus (CMV) have a significant impact on microbe and immune cell populations and how the immune system responds to the influenza vaccine. The study was published in the Journal of Virology.

3 Aug 2018

Researchers shed new light on how bacteria sense nutrients in their environment

University of Leicester researchers have shed new light on how bacteria sense nutrients in their environment - which could provide important knowledge in the development of drugs and antibiotics to combat a range of diseases including tuberculosis.

3 Aug 2018

Discovery of new epithelial lung cell type may affect cystic fibrosis therapy

Scientists have discovered a new type of cell in the human respiratory tract called the pulmonary ionocyte, and linked it to cystic fibrosis.

3 Aug 2018

Researchers discover new mechanism linked to inherited breast, ovarian cancer

Researchers from Manchester University NHS Foundation Trust and The University of Manchester have identified a new mechanism which switches off a gene in families affected by breast and ovarian cancer.

3 Aug 2018

UW-Madison researcher explores how female fertility is affected by development of the ovary in mice

When Joan Jorgensen was an undergraduate at the University of Wisconsin–Madison, her roommate confided that she had just one period before going through menopause in high school.

3 Aug 2018

Genome-wide association study identifies 151 genes for atrial fibrillation

Drawing on genomic data from more than one million individuals, researchers from the University of Michigan have led a large collaborative effort to discover as-yet unknown genetic risk factors for atrial fibrillation: an irregular, often rapid heart rate affecting millions of Americans and more than 30 million people worldwide.

3 Aug 2018

Study sheds new light on link between calorie-burning fat and muscle function

Abundant in human babies and small mammals, brown adipose tissue, or brown fat, was only recently discovered in human adults, and its role remains unclear.

3 Aug 2018

Scientists map regulatory landscape of mouse genome at single-cell resolution

Scientists have completed a major effort to map the regulatory landscape of the mouse genome at a single-cell resolution.

2 Aug 2018

MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

A Massachusetts General Hospital research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma - the second most common bone cancer in children and young adults - unleashes tumor growth.

2 Aug 2018

Researchers use DNA editing tool to reveal mechanisms behind autoimmune diseases

A group of researchers at the University of São Paulo in Brazil used a DNA editing tool called CRISPR/Cas9 to manipulate on of the genes associated to the autoaggressive T lymphocytes responsible for inducing autoimmune diseases such as autoimmune polyglandular syndrome type 1 and type 1 diabetes.

2 Aug 2018

Simple pH imbalance could be a root of Alzheimer’s disease, mouse study shows

Johns Hopkins Medicine scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline - or pH - chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells.

2 Aug 2018

Innovative 'EvolvR' system lets scientists shuffle genes until they get right variation

Scientists at the Innovative Genomics Institute have concocted a transformative new way to harness the power of evolution.

2 Aug 2018

Researchers study how herpesviruses contribute to increased oral inflammation

A $2 million grant from the National Institutes of Health will help University of Illinois at Chicago researchers study how herpesviruses, and their underlying molecular mechanisms, contribute to increased inflammation in oral diseases, like periodontitis

2 Aug 2018

Scientists solve 60-year-old mystery of how thalidomide caused birth defects

More than 60 years after the drug thalidomide caused birth defects in thousands of children whose mothers took the drug while pregnant, scientists at Dana-Farber Cancer Institute have solved a mystery that has lingered ever since the dangers of the drug first became apparent: how did the drug produce such severe fetal harm?

2 Aug 2018

Pioneering research takes major step forward in the fight against cystic fibrosis

The fight against cystic fibrosis has taken a major step forward, with pioneering research by University of Adelaide scientists showing that cells causing the debilitating genetic disorder could be successfully replaced with healthy ones.

2 Aug 2018