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Researchers identify mutation in ITGA10 gene that causes chondrodysplasia in dog breeds

Professor Hannes Lohi's research group at the University of Helsinki and Folkhälsan Research Center has identified a mutation in ITGA10 gene, causing chondrodysplasia in two dog breeds, the Norwegian Elkhound and the Karelian Bear Dog.

26 Sep 2013

Copenhagen researchers gain insight in molecular mechanisms behind breast cancer metastasis

Researchers at University of Copenhagen have gained more insight into the molecular mechanisms of importance for, for example, cancer cell growth and metastasis. The research objective is improved and more targeted drugs. The findings have just been published in the scientific journal Molecular Cell.

26 Sep 2013

Study on tempol impacted gut bacteria may lead to new treatments for obesity

A drug that appears to target specific intestinal bacteria in the guts of mice may create a chain reaction that could eventually lead to new treatments for obesity and diabetes in humans, according to a team of researchers.

25 Sep 2013

Researchers identify molecular pathway linking ICU ventilation to brain damage

At least 30 percent of patients in intensive care units (ICUs) suffer some form of mental dysfunction as reflected in anxiety, depression, and especially delirium. In mechanically-ventilated ICU patients, the incidence of delirium is particularly high, about 80 percent, and may be due in part to damage in the hippocampus, though how ventilation is increasing the risk of damage and mental impairment has remained elusive.

25 Sep 2013

NCI Funds Development Of Chrysalis’ Brain Tissue Damage Treatment

The National Cancer Institute awarded Chrysalis BioTherapeutics a $1.5 million contract to continue development of Chrysalin® to mitigate radiotherapy-induced damage to normal brain tissue. The project is a collaboration between Chrysalis, Baylor College of Medicine, and the University of Texas Medical Branch (UTMB).

24 Sep 2013

Inflammation tracks mania course

Markers of inflammation are elevated in patients who are hospitalized for acute mania, a study shows.

24 Sep 2013

Rhythm starts RM-493 clinical trials in obesity patients with genetic deficiency

Rhythm announced today the initiation of the first of a series of clinical trials with RM-493, the company's novel melanocortin 4 receptor (MC4R) agonist, for the treatment of obesity in individuals with a genetic deficiency in the MC4R pathway.

24 Sep 2013

Karo Bio, 4D Science Team Up On Treatments For Fibrotic Diseases

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23 Sep 2013

Abbvie, Ablynx Ink Up To $840M RA, SLE Collaboration

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23 Sep 2013

New study on propofol drug may help develop effective anesthetics with fewer side effects

Researchers at Washington University School of Medicine in St. Louis and Imperial College London have identified the site where the widely used anesthetic drug propofol binds to receptors in the brain to sedate patients during surgery.

23 Sep 2013

PGI2 analogs, PDE5 inhibitors stimulate enhanced release of vasodilator ATP from human RBCs

Researchers at Saint Louis University School of Medicine have discovered a novel interaction between prostacyclin analogs and phosphodiesterase 5 inhibitors, two groups of drugs used in the treatment of pulmonary arterial hypertension.

21 Sep 2013

Research on synapse stabilization aids understanding of autism, schizophrenia, intellectual disability

When we're born, our brains aren't very organized. Every brain cell talks to lots of other nearby cells, sending and receiving signals across connections called synapses.

21 Sep 2013

Researchers make new breakthroughs in brain circuitry controlling fertility

In a landmark discovery, the final piece in the puzzle of understanding how the brain circuitry vital to normal fertility in humans and other mammals operates has been put together by researchers at New Zealand's University of Otago.

21 Sep 2013

New cellular switch could eventually inhibit growth of aggressive malignant brain tumor

Researchers at UT Southwestern Medical Center have identified a cellular switch that potentially can be turned off and on to slow down, and eventually inhibit the growth of the most commonly diagnosed and aggressive malignant brain tumor.

21 Sep 2013

Human breast tumors transplant could be valuable tools in search for better treatments

Breast cancer that spreads to other organs is extremely difficult to treat. Doctors can buy patients time, but a cure remains elusive. Now, researchers at Washington University School of Medicine in St. Louis have shown that human breast tumors transplanted into mice are excellent models of metastatic cancer and could be valuable tools in the search for better treatments.

20 Sep 2013

GSK Returns Vercirnon Rights To Chemocentryx After Phase III Flop

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19 Sep 2013

Overactivity of EGFR protein leads to heightened cancer growth and chemotherapy resistance

Overactivity of a protein that normally cues cells to divide sabotages the body-s natural cellular recycling process, leading to heightened cancer growth and chemotherapy resistance, UT Southwestern Medical Center researchers have found.

19 Sep 2013

New information about how estrogens regulate memory formation

The loss of estrogens at menopause increases a woman's risk of dementia and Alzheimer's disease, yet hormone replacement therapy can cause harmful side effects.

19 Sep 2013

GSK Returns Vercirnon Rights To Chemocentryx After Phase III Flop

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18 Sep 2013

Smokers with a history of major depressive disorder (MDD) taking varenicline have significantly higher likelihood of quitting smoking than placebo

Results of a Pfizer-commissioned study published this month in Annals of Internal Medicine reveal that smokers with a past or present diagnosis of major depressive disorder (MDD)* taking varenicline had a significantly higher likelihood of quitting smoking (after 12 weeks and at 52 weeks) than those who were given a placebo.

18 Sep 2013

Receptor News and Research

Researchers identify mutation in ITGA10 gene that causes chondrodysplasia in dog breeds

Copenhagen researchers gain insight in molecular mechanisms behind breast cancer metastasis

Study on tempol impacted gut bacteria may lead to new treatments for obesity

Researchers identify molecular pathway linking ICU ventilation to brain damage

NCI Funds Development Of Chrysalis’ Brain Tissue Damage Treatment

Inflammation tracks mania course

Rhythm starts RM-493 clinical trials in obesity patients with genetic deficiency

Karo Bio, 4D Science Team Up On Treatments For Fibrotic Diseases

Abbvie, Ablynx Ink Up To $840M RA, SLE Collaboration

New study on propofol drug may help develop effective anesthetics with fewer side effects

PGI2 analogs, PDE5 inhibitors stimulate enhanced release of vasodilator ATP from human RBCs

Research on synapse stabilization aids understanding of autism, schizophrenia, intellectual disability

Researchers make new breakthroughs in brain circuitry controlling fertility

New cellular switch could eventually inhibit growth of aggressive malignant brain tumor

Human breast tumors transplant could be valuable tools in search for better treatments

GSK Returns Vercirnon Rights To Chemocentryx After Phase III Flop

Overactivity of EGFR protein leads to heightened cancer growth and chemotherapy resistance

New information about how estrogens regulate memory formation

GSK Returns Vercirnon Rights To Chemocentryx After Phase III Flop

Smokers with a history of major depressive disorder (MDD) taking varenicline have significantly higher likelihood of quitting smoking than placebo

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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