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New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

A new therapeutic agent tested in a mouse model of multiple sclerosis (MS) produced anti-inflammatory activity and prevented loss of cells in the optic nerve, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania, with Pittsburgh-based Noveome Biotherapeutics.

9 Feb 2017

New treatment may hold promise for progressive form of multiple sclerosis, study suggests

A research team led by scientists from Brigham and Women's Hospital has revealed how an FDA-approved drug works in the central nervous system in mice to suppress chronic inflammation.

9 Feb 2017

Researchers uncover key molecular pathways behind gut bacterial imbalance during inflammation

A study led by UT Southwestern Medical Center researchers has uncovered key molecular pathways behind the disruption of the gut's delicate balance of bacteria during episodes of inflammatory disease.

8 Feb 2017

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

Investigators at the Medical University of South Carolina report pre-clinical research showing that a genetic variant encoded in neutrophil cystolic factor 1 (NCF1) is associated with increased risk for autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and Sjögren's syndrome, in the January 2017 issue of Nature Genetics.

8 Feb 2017

ADA funds Kostic lab to support research on links between gut bacteria and autoimmune attack

The American Diabetes Association has awarded Joslin Diabetes Center assistant investigator Aleksandar Kostic, Ph.D., a $1.625-million grant under its Pathway to Stop Diabetes program, which seeks to bring new investigators and new perspectives to diabetes research.

8 Feb 2017

VA scientists reveal new theory on how aspirin may ward off cancer

Studies abound that point to a role for plain old aspirin in keeping deadly cancers at bay. While aspirin is not yet part of mainstream treatment for any cancer, it is recommended by the U.S. Preventive Services Task Force for certain adults to help prevent colorectal cancer.

8 Feb 2017

New ‘release and kill’ strategy may shorten treatment periods for patients with tuberculosis

Mycobacterium tuberculosis has been called "the perfect pathogen." These bacteria hijack human macrophages, persist inside the cells to evade immune destruction, and then prevent the macrophage from undergoing programmed cell death.

8 Feb 2017

Study sheds light on role of Armc5 protein in foetal development and T-cell immune responses

Genetic mutations of the Armc5 gene disrupt foetal development and compromise the immune response.

8 Feb 2017

Penn scientists discover clues that could lead novel therapies for preventing heart failure

Of the more than 700,000 Americans who suffer a heart attack each year, about a quarter go on to develop heart failure.

7 Feb 2017

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

Bladder dysfunction is a reality for about half of patients with diabetes and now scientists have evidence that an immune system receptor that's more typically activated by bacteria is a major contributor.

7 Feb 2017

UNC scientists isolate protein that could play role in asthmatics

Researchers at the UNC School of Medicine believe they have isolated a protein that, when missing or depleted, can cause airway constriction, production of mucus, chest tightness, and difficulty breathing for the 334 million people worldwide who suffer from asthma.

6 Feb 2017

Researchers evaluate biological effects of exposure to cigarette smoke versus e-cigarette aerosols

Researchers reported changes in the expression levels of 123 genes when reconstituted lung tissue was exposed to cigarette smoke, compared to only two genes that could be confirmed following exposure to e-cigarette aerosols.

6 Feb 2017

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and King's College London have discovered a treatment that improves the neurological symptoms in a mouse model of juvenile Batten disease.

6 Feb 2017

Penn scientists find cytokine as key to fighting and treating viral infection in the lungs

Viral infections that occur in a patient's lungs are a significant cause of hospitalization and death among children and the elderly.

3 Feb 2017

Thirdhand smoke exposure leads to biological effects on weight and cell development

The sticky residue left behind by tobacco smoke can do worse damage than stinking up furniture and discoloring walls.

3 Feb 2017

Sleep may be regulated by several brain-based immune proteins, study reveals

Sleep -- one of the most basic, yet most mystifying processes of the human body -- has confounded physicians, scientists and evolutionary biologists for centuries.

2 Feb 2017

NIH researchers shed light on role of S. epidermidis toxin in bacterial sepsis

Staphylococcus epidermidis bacteria are a significant health concern for hospitalized infants, children and anyone with implanted medical devices.

2 Feb 2017

Researchers receive $2 million grant from PCORI to study effective treatment for children with KD

Kawasaki disease (KD) is an uncommon illness that affects blood vessels in the hearts of children

2 Feb 2017

Researchers identify new mechanism that protects from bacterial infections

An international team led by the University if Barcelona has identified a new antibacterial mechanism that protects macrophages - defense cells in the immune system- from the infection of the bacteria Salmonella enterica serovar Typhimurium, a pathogen associated with several gastrointestinal diseases.

2 Feb 2017

Autologous hematopoietic cell transplant may induce sustained remission of multiple sclerosis

New clinical trial results provide evidence that high-dose immunosuppressive therapy followed by transplantation of a person's own blood-forming stem cells can induce sustained remission of relapsing-remitting multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system.

2 Feb 2017

Inflammation News and Research

New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

New treatment may hold promise for progressive form of multiple sclerosis, study suggests

Researchers uncover key molecular pathways behind gut bacterial imbalance during inflammation

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

ADA funds Kostic lab to support research on links between gut bacteria and autoimmune attack

VA scientists reveal new theory on how aspirin may ward off cancer

New ‘release and kill’ strategy may shorten treatment periods for patients with tuberculosis

Study sheds light on role of Armc5 protein in foetal development and T-cell immune responses

Penn scientists discover clues that could lead novel therapies for preventing heart failure

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

UNC scientists isolate protein that could play role in asthmatics

Researchers evaluate biological effects of exposure to cigarette smoke versus e-cigarette aerosols

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Penn scientists find cytokine as key to fighting and treating viral infection in the lungs

Thirdhand smoke exposure leads to biological effects on weight and cell development

Sleep may be regulated by several brain-based immune proteins, study reveals

NIH researchers shed light on role of S. epidermidis toxin in bacterial sepsis

Researchers receive $2 million grant from PCORI to study effective treatment for children with KD

Researchers identify new mechanism that protects from bacterial infections

Autologous hematopoietic cell transplant may induce sustained remission of multiple sclerosis

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Bringing real-time analytics to downstream bioprocess monitoring

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Evaluating new approaches for rare disease genomics

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