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Testing for tumor DNA can help predict risk of relapse after transplant in DLBCL patients

Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse.

7 Dec 2020

Xylitol and grapefruit seed extract shows promise in preventing SARS-CoV-2 infection, study finds

A team of researchers at the Feinberg School of Medicine demonstrated that xylitol and grapefruit seed extract (GSE) could prevent SARS-CoV-2 infection. These can be used as a nasal spray to contain the spread of the coronavirus.

7 Dec 2020

Study assesses different pipelines for timing mutations in cancer genomes

UCLA Jonsson Comprehensive Cancer Center researchers studying cancer evolution have created a framework to help determine which tool combinations are best for pinpointing the exact timing of DNA mutations in cancer genomes.

7 Dec 2020

Obesity linked to mortality gap between Black and white women with early breast cancer

In an analysis of women with early breast cancer, Black women had higher rates of obesity and other health conditions that can affect survival, compared with white women.

7 Dec 2020

Targeting senescent 'zombie' cells may improve survival in women with cervical cancer

How well women with cervical cancer respond to treatment and survive correlates with the level of 10 proteins in their blood that also are associated with a "zombie" cell state called senescence, Medical College of Georgia scientists report.

7 Dec 2020

Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

A new study indicates that the topoisomerase 1 (Top1) is intimately related to the lethal inflammation associated with SARS-CoV-2 infection in a large proportion of cases.

7 Dec 2020

Researchers identify new target that may lead to novel treatment for Alzheimer’s disease

Researchers at the Case Western Reserve University School of Medicine have identified a new target in development of Alzheimer's disease (AD) that could lead to therapies focused on treating the neurodegenerative condition early in its progression.

7 Dec 2020

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Clinical investigators from Hackensack Meridian Health John Theurer Cancer Center (JTCC), a member of the Georgetown Lombardi Comprehensive Cancer Center consortium, are to present updates on treatment advances in multiple myeloma (MM), mantle cell lymphoma (MCL), and other types of B-cell lymphoma (BCL) as well as leukemia at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, to be held virtually from December 5-8, 2020.

7 Dec 2020

Combination of venetoclax and standard therapies shows promise in high-risk myeloid blood cancers

The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute.

7 Dec 2020

Researchers identify potential drug combination to treat uveal melanoma

Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) have identified a potential drug combination to treat uveal melanoma, a type of eye cancer.

7 Dec 2020

Study: CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial.

6 Dec 2020

Lung tissue analysis reveals promising molecular target to ameliorate pulmonary fibrosis

An analysis of lung tissues from patients with different types of pulmonary fibrosis - including cases triggered by COVID-19 - has revealed a promising molecular target to ameliorate the chronic and irreversible disease.

5 Dec 2020

Researchers develop wound-healing gel based on a substance produced by Trichoderma fungi

Researchers from the Department of Biochemistry of RUDN University developed a wound-healing gel based on a substance that is produced by Trichoderma fungi.

5 Dec 2020

Matrix-induced autologous chondrocyte implantation shows comparable benefit to therapy alternatives

Autologous chondrocyte implantation (ACI) has been used in adults with deep cartilage defects for over 30 years and has been further developed and modified over time.

5 Dec 2020

Secukinumab for treatment of plaque psoriasis in children: Added benefit not proven

The monoclonal antibody secukinumab is approved for the treatment of moderate to severe plaque psoriasis in children and adolescents from the age of six years who are candidates for systemic therapy.

5 Dec 2020

Findings about primary cilia may be relevant for transplantation therapies in diabetes

A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets.

5 Dec 2020

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease.

5 Dec 2020

Therapy News and Research

Testing for tumor DNA can help predict risk of relapse after transplant in DLBCL patients

Xylitol and grapefruit seed extract shows promise in preventing SARS-CoV-2 infection, study finds

Study assesses different pipelines for timing mutations in cancer genomes

Obesity linked to mortality gap between Black and white women with early breast cancer

Targeting senescent 'zombie' cells may improve survival in women with cervical cancer

Topoisomerase 1 inhibition prevents SARS-CoV-2-induced inflammation and death in animal models

Researchers identify new target that may lead to novel treatment for Alzheimer’s disease

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Combination of venetoclax and standard therapies shows promise in high-risk myeloid blood cancers

Researchers identify potential drug combination to treat uveal melanoma

Study: CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

Lung tissue analysis reveals promising molecular target to ameliorate pulmonary fibrosis

Researchers develop wound-healing gel based on a substance produced by Trichoderma fungi

Matrix-induced autologous chondrocyte implantation shows comparable benefit to therapy alternatives

Secukinumab for treatment of plaque psoriasis in children: Added benefit not proven

Findings about primary cilia may be relevant for transplantation therapies in diabetes

Study finds surprising link between ALS, FTD and Huntington's disease-associated mutation

Using gene therapy to achieve the positive health effects of physical exercise

Missing link between stress and infertility found

β-AR agonist therapy may prevent metastasis in oral squamous cell carcinoma

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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