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Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

Researchers in the UK have warned that a widespread mutation that has arisen in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to escape recognition by CD8 T-cell responses in both convalescent patients and recipients of the current coronavirus disease 2019 (COVID-19) vaccines.

29 Jun 2021

Promising preclinical results of new dementia treatment candidate set the stage for human trials

Researchers have identified a new treatment candidate that appears to not only halt neurodegenerative symptoms in mouse models of dementia and Alzheimer's disease, but also reverse the effects of the disorders.

29 Jun 2021

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer's disease.

29 Jun 2021

Six antibody features could be used to identify women at risk of placental malaria

Six antibody characteristics could help scientists identify which pregnant women are at risk of placental malaria infections, finds a study published today in eLife.

29 Jun 2021

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

Skoltech researchers and their colleagues from Russia and the UK investigated the safety and efficacy of new chemistry in antisense oligonucleotides used to treat spinal muscular atrophy (SMA), a debilitating genetic disease.

29 Jun 2021

More evidence that mixing COVID-19 vaccines may help elicit a robust immune response

Eight volunteers who received a complete dose or a single dose of an mRNA vaccine or the ChAdOx1 vaccine after a dose of a trial gorilla adenovirus vaccine showed a significantly high level of antibodies and T cell response against SARS-CoV-2.

29 Jun 2021

Study investigates the link between skeletal muscle proteome and type 2 diabetes

Globally, more than 400 million people have diabetes, most of them suffering from type 2 diabetes.

29 Jun 2021

The technology behind face masks that can diagnose COVID-19

Researchers have recently incorporated technology into standard face masks to detect the presence of SARS-CoV-2.

29 Jun 2021

Cationic peptides inhibit SARS-CoV-2 cell entry

In a paper recently published in Pathogens, in silico affinity studies by researchers at the University of Illinois, USA, reveal several potential peptide binding sites required for HS-spike protein and ACE2-spike protein bond formation, and synthesis of suitable peptide inhibitors reveals impaired SARS-CoV-2 cell entry.

29 Jun 2021

Nanotechnology and the fight against COVID-19

In a review paper published in the open-access MDPI journal Viruses, a team of researchers explored the potential of nanotechnology to alleviate the current and future coronavirus burden. The team focused on its potential role in the detection, diagnosis, protection, and treatment of SARS-CoV-2 infection.

29 Jun 2021

Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

Researchers have found that the y cross-chain structure of fibrin proteins is essential to stabilizing blood clots that can lead to harmful embolism formation.

29 Jun 2021

Study explores structure, activity, and inhibition of TMPRSS2 implicated in SARS-CoV-2 activation

Researchers from Canada recently presented an efficient strategy for recombinant production of enzymatically active TMPRSS2 ectodomain, enabling enzymatic characterization and the 1.95 Å X-ray crystal structure. Their work is published on the bioRxiv* preprint server while awaiting peer-review.

29 Jun 2021

H69/V70 deletion in Alpha variant enables SARS-CoV-2 to overcome chinks in its armor

One of the key mutations seen in the 'Alpha variant' of SARS-CoV-2 - the deletion of two amino acids, H69/V70 - enables the virus to overcome chinks in its armor as it evolves, say an international team of scientists.

29 Jun 2021

SARS-CoV-2 infection induces accumulation of lipids and N-proteins

Scientists from the Netherlands and the US recently studied the localization of the SARS-CoV-2 proteins in postmortem lung tissues of COVID-19 patients and in SARS-CoV-2 infected Vero cells that were processed identically. The research is posted to the bioRxiv* preprint server, prior to peer review.

29 Jun 2021

Acidic environment enhances production of butyric acid from apple pectin by fecal microbiota

Researchers from Tallinn University of Technology, Grete Raba, Signe Adamberg, and Kaarel Adamberg showed that an acidic environment enhances the production of butyric acid from apple pectin by fecal bacterial consortia - microbiota.

29 Jun 2021

New study reveals how heparan sulfate promotes amyloid deposition in various organs

Amyloid diseases, including Alzheimer's, Parkinson's, type-2 diabetes and other life-threatening diseases, involve pathologic deposits of normally soluble proteins or peptides as insoluble amyloid fibrils. When this happens in vital organs, such as the brain, kidney, liver and heart, it causes organ damage and, if left untreated, death. Unfortunately, the available treatment options are very limited.

29 Jun 2021

Two CU Cancer Center studies provide insights into the link between inflammation and leukemia

Two recent collaborative publications by CU Cancer Center members provide insights into how chronic inflammation can serve as a key factor in the development of leukemia and other blood cancers.

29 Jun 2021

Immune response to FDA-approved vaccines is strong and potentially long-lasting

The first two COVID-19 vaccines authorized for emergency use by the Food and Drug Administration (FDA) employed a technology that had never before been used in FDA-approved vaccines.

29 Jun 2021

Differences in monocyte subsets between severe COVID-19 and long COVID

Researchers in the United States and Costa Rica have identified differences in the proportions of monocyte subsets that occur in severe cases of coronavirus disease 2019 (COVID-19) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and post-acute sequelae of COVID-19 (PASC), often referred to as “Long COVID”.

28 Jun 2021

Specific lung cell exhibits immune properties and improves respiratory viral disease outcomes

Researchers at Children's Hospital of Philadelphia have discovered that a specific type of lung cell exhibits unconventional immune properties and may contribute to the outcome of respiratory viral infections.

28 Jun 2021

Protein C News and Research

Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

Promising preclinical results of new dementia treatment candidate set the stage for human trials

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

Six antibody features could be used to identify women at risk of placental malaria

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

More evidence that mixing COVID-19 vaccines may help elicit a robust immune response

Study investigates the link between skeletal muscle proteome and type 2 diabetes

The technology behind face masks that can diagnose COVID-19

Cationic peptides inhibit SARS-CoV-2 cell entry

Nanotechnology and the fight against COVID-19

Findings suggest that the cross-linking of fibrin proteins is key to reducing blood clot formation

Study explores structure, activity, and inhibition of TMPRSS2 implicated in SARS-CoV-2 activation

H69/V70 deletion in Alpha variant enables SARS-CoV-2 to overcome chinks in its armor

SARS-CoV-2 infection induces accumulation of lipids and N-proteins

Acidic environment enhances production of butyric acid from apple pectin by fecal microbiota

New study reveals how heparan sulfate promotes amyloid deposition in various organs

Two CU Cancer Center studies provide insights into the link between inflammation and leukemia

Immune response to FDA-approved vaccines is strong and potentially long-lasting

Differences in monocyte subsets between severe COVID-19 and long COVID

Specific lung cell exhibits immune properties and improves respiratory viral disease outcomes

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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