Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

After SARS-CoV-2 booster dose memory B cells adapt to Omicron

Memory B cells never forget recurrent viral exposures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is no exception, according to a new medRxiv* preprint study.

5 Jan 2022

Change in glutathione reductase lowers inflammation in present-day humans

Very few proteins in the body have a change that makes them unique compared to the corresponding proteins in Neanderthals and apes.

5 Jan 2022

Scientists estimate transmission advantage of Omicron over Delta variant as +105%

Researchers use statistical models to assess the transmission of the SARS-CoV-2 Omicron using variant-specific screening tests and genome sequencing.

5 Jan 2022

Booster dose elicits cross-reactive humoral immunity against SARS-CoV-2 Delta and Omicron variants

Researchers determine the cross-reactivity of the SARS-CoV-2 spike glycoprotein-induced antibodies before and after a third SARS-CoV-2 vaccine dose.

5 Jan 2022

Monoclonal antibody treatment of COVID-19 reduces viral shedding

Researchers aim to understand the potential benefits of mAbs in preventing and treating SARS-CoV-2 infection.

5 Jan 2022

First-responder cells launching the repair after heart attack promote inflammation overdrive

First-responder cells launching the repair after a heart attack are so frantic about fixing the damage that they promote more inflammation than necessary, new research in mice suggests.

5 Jan 2022

New CRISPR-based assay can non-invasively detect a biomarker of acute kidney rejection in urine

When a patient receives a kidney transplant, doctors carefully monitor them for signs of rejection in several ways, including biopsy. However, this procedure is invasive and can only detect issues at a late stage.

5 Jan 2022

Wistar announces initiation of Phase 2 clinical study of VK-2019 in patients with advanced head and neck cancer

The Wistar Institute announces the initiation of a Phase 2 clinical study of VK-2019 in patients with advanced Epstein-Barr Virus (EBV)-positive nasopharyngeal carcinoma (NPC) and lymphoma.

5 Jan 2022

Integrin/TGF-β1 inhibitors highly effective in attenuating COVID-19 severity

New study results suggest that integrin inhibitors have the potential to both prevent infection with SARS-CoV-2, including the Delta and Omicron variants, and to decrease TGF-β levels, resulting in a decrease in COVID-19 severity, hospitalization, and death, especially in vulnerable and unvaccinated populations.

5 Jan 2022

Exploring SARS-CoV-2-like viruses to mitigate the risk of zoonotic transmission to humans

In a new study, a team of researchers developed a genetic assay to evaluate several clade 2 and clade 3 receptor-binding domains (RBD) of spike (S) protein sequences of genus sarbecovirus.

5 Jan 2022

Hospitalization and death associated with SARS-CoV-2 Omicron variant compared to Delta variant

Researchers evaluate the rates of hospitalization and deaths associated with the SARS-CoV-2 Omicron variant as compared to the Delta variant.

5 Jan 2022

Comparison of the mutational profile of Omicron with other SARS-CoV-2 lineages

Researchers from nference labs in Massachusetts have been examining the origins of a particular mutation in the Omicron variant.

5 Jan 2022

COVID-19 mRNA vaccines offer protection against Omicron variant in pregnancy

A new study provides insights into the persistence of extra-neutralizing properties of mRNA vaccine-induced antibodies resulting in protection against the Omicron variant of SARS-CoV-2.

5 Jan 2022

Efficacy of COVID-19 convalescent plasma therapy in patients with hematological malignancies and COVID-19

Scientists recently demonstrated the efficacy of COVID-19 convalescent plasma therapy in improving the survival rate among patients with B-cell lymphoid malignancy and COVID-19.

5 Jan 2022

Oral bacteria-based SARS-CoV-2 vaccine platform

In a new study, researchers engineered the bacterial strain, Salmonella, to express differently-sized antigens to serve as vaccine platforms.

5 Jan 2022

Nucleocapsid protein preferentially binds to structured and longer RNA to deliver viral proteins in host circulation

Results from a new study could be crucial in studying the molecular and biochemical basis of SARS-CoV-2 infection at a more granular level and help in strategizing therapeutic solutions to treat and manage COVID-19 effectively.

5 Jan 2022

Can the COVID-19 delta variant evade vaccine-induced immunity?

Can the COVID-19 delta variant evade vaccine-induced immunity? We spoke to Professor Brian J. Willett from the University of Glasgow to find out.

5 Jan 2022

mRNA booster vaccine confers strong protection against SARS-CoV-2 Omicron in cancer patients

A new preprint research paper posted to the medRxiv* server reports the induction of high neutralizing activity in these patients against the Omicron VOC with a booster dose.

5 Jan 2022

Scientists provide a structural framework for Omicron immune evasion and ACE2 receptor recognition

An interesting preprint research paper describes structural changes resulting from the multiple mutations found in the recent Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is the causative agent behind the coronavirus disease 2019 (COVID-19) pandemic. In addition, the research describes the consequent effects of these changes on Omicron’s infectivity and immune evasion capabilities.

5 Jan 2022

Transplant recipients benefit from a COVID-19 vaccine booster

A new preprint research paper posted to the medRxiv* server describes the reduction in humoral immunity in SOTR following vaccination, as well as the improvement with an additional dose of the vaccine.

4 Jan 2022

Protein News and Research

Further Reading

After SARS-CoV-2 booster dose memory B cells adapt to Omicron

Change in glutathione reductase lowers inflammation in present-day humans

Scientists estimate transmission advantage of Omicron over Delta variant as +105%

Booster dose elicits cross-reactive humoral immunity against SARS-CoV-2 Delta and Omicron variants

Monoclonal antibody treatment of COVID-19 reduces viral shedding

First-responder cells launching the repair after heart attack promote inflammation overdrive

New CRISPR-based assay can non-invasively detect a biomarker of acute kidney rejection in urine

Wistar announces initiation of Phase 2 clinical study of VK-2019 in patients with advanced head and neck cancer

Integrin/TGF-β1 inhibitors highly effective in attenuating COVID-19 severity

Exploring SARS-CoV-2-like viruses to mitigate the risk of zoonotic transmission to humans

Hospitalization and death associated with SARS-CoV-2 Omicron variant compared to Delta variant

Comparison of the mutational profile of Omicron with other SARS-CoV-2 lineages

COVID-19 mRNA vaccines offer protection against Omicron variant in pregnancy

Efficacy of COVID-19 convalescent plasma therapy in patients with hematological malignancies and COVID-19

Oral bacteria-based SARS-CoV-2 vaccine platform

Nucleocapsid protein preferentially binds to structured and longer RNA to deliver viral proteins in host circulation

Can the COVID-19 delta variant evade vaccine-induced immunity?

mRNA booster vaccine confers strong protection against SARS-CoV-2 Omicron in cancer patients

Scientists provide a structural framework for Omicron immune evasion and ACE2 receptor recognition

Transplant recipients benefit from a COVID-19 vaccine booster

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