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Compugen program shows potential for development of new immunotherapy treatments for solid tumors

Compugen Ltd., a leading predictive drug discovery company, today presented new data for its preclinical CGEN-15029 program demonstrating the potential for the development of new cancer immunotherapy treatments for solid tumors, including the potential for drug combination with current immune checkpoint blockers.

11 Nov 2016

Two genes linked to increase in immunity to hepatitis C after childbirth, study shows

Alternative forms of two genes are associated with a boost in immunity to hepatitis C after childbirth, a study led by a Nationwide Children's Hospital physician-researcher shows.

31 Oct 2016

Broadly neutralizing HIV antibodies open new avenues for development of effective vaccine

A small number of people infected with HIV produce antibodies with an amazing effect: Not only are the antibodies directed against the own virus strain, but also against different sub-types of HIV that circulate worldwide.

26 Sep 2016

Researchers develop innovative technique for detecting HIV hiding places in infected patients

Discovery of a novel, advanced technique to identify the rare cells where human immunodeficiency virus (HIV) hides in patients taking antiretroviral therapy (ART). This is an important step forward in the search for a HIV/AIDS cure.

19 Sep 2016

TSRI, IAVI scientists reveal new reductionist vaccine strategy to fight against HIV

A series of new studies led by scientists at The Scripps Research Institute and the International AIDS Vaccine Initiative describe a potential vaccination strategy to jump-start the selection and evolution of broadly effective antibodies to prevent HIV infection.

13 Sep 2016

Right dose of CAR T cells and lymphodepletion can achieve good response rates for NHL patients

In a paper published today in Science Translational Medicine, researchers from Fred Hutchinson Cancer Research Center shared data from an early-phase study of patients with advanced non-Hodgkin lymphoma (NHL) who received JCAR014, a Chimeric Antigen Receptor (CAR) T cell treatment, and chemotherapy.

9 Sep 2016

Stealth insulin-producing pig cells may offer solution for treating Type 1 diabetes in humans

University of Alabama at Birmingham researchers are exploring ways to wrap pig tissue with a protective coating to ultimately fight diabetes in humans. The nano-thin bilayers of protective material are meant to deter or prevent immune rejection.

8 Sep 2016

Researchers discover second line of defense in macaques co-infected with Mtb and SIV

Tulane University researchers found some monkeys whose immune systems are depleted by the simian strain of HIV have a second line of defense against tuberculosis.

7 Sep 2016

Curbing immune system infighting could make treatment more effective for pancreatic cancer

Internal conflict between cell types explains why the immune system struggles to recognize and attack pancreatic cancer.

25 Aug 2016

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

iCell Gene Therapeutics today (Aug. 11) announced that the Food and Drug Administration has granted Orphan Drug Designation for its chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR) for the treatment of peripheral T-cell lymphoma (PTCL).

12 Aug 2016

Analysis of biopsies during early treatment predicts patient’s response to melanoma immunotherapy

Immune response measured in tumor biopsies during the course of early treatment predicts which melanoma patients will benefit from specific immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cancer Discovery.

11 Aug 2016

GW researchers identify new way to regulate chronic toxoplasmosis

New research critical to treatment for chronic toxoplasmosis, one of the most common parasitic diseases worldwide, was published in the Journal of Experimental Medicine.

2 Aug 2016

CD4/CD8 ratio biomarker could help identify HIV-infected individuals at risk for heart disease

The ratio of CD4 to CD8 T cells in the blood-a marker of immune system health and associated with mortality risk in the general population-is an independent predictor of coronary heart disease in HIV-infected patients, according to a new study published in AIDS Research and Human Retroviruses, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

29 Jul 2016

Combining ART with immune-enhancing treatment may destabilize HIV reservoirs

Although antiretroviral therapy (ART) can reduce the amount of HIV in the blood to an undetectable level in most chronically infected people, it cannot eliminate reservoirs of HIV that persist in latently infected immune cells.

21 Jul 2016

Anti-HIV medications provide durable protection against heterosexual transmission, study finds

Anti-HIV medications suppress the viral load of people living with HIV and provide durable protection against heterosexual transmission a study led by the University of North Carolina at Chapel Hill found.

19 Jul 2016

Maternal antiretroviral treatment eliminates HIV transmission to infants during breastfeeding

For HIV-infected mothers whose immune system is in good health, taking a three-drug antiretroviral regimen during breastfeeding essentially eliminates HIV transmission by breast milk to their infants, according to results from a large clinical trial conducted in sub-Saharan Africa and India.

19 Jul 2016

New treatment may destroy HIV's last refuge

UK scientists may have found a way to destroy HIV's last refuge. A study by Oxford University has confirmed that a treatment developed by a British company can remove the virus in its chosen hiding place, in laboratory conditions, offering hope of a viable treatment.

15 Jul 2016

Key differences in immune response may explain young children’s proneness to infecion

Schools are commonly known as breeding grounds for viruses and bacteria, but this may not necessarily be linked to hygiene.

4 Jul 2016

Researchers develop computer model for speed analysis of TB's complex life-cycle

Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis, is a serious global health problem accounting for 1.3 million worldwide deaths annually.

1 Jul 2016

Researchers find unexpected connection between two types of calming immune cells

Biologically speaking, we carry the outside world within us. The food we ingest each day and the trillions of microbes that inhabit our guts pose a constant risk of infection--and all that separates us from these foreign entities is a delicate boundary made of a single layer of cells.

15 Jun 2016