Signaling Pathway News and Research

RSS

Researchers identify new in-utero treatment to reverse cleft palate in mouse models

Researchers at University of Utah Health clarified a molecular pathway responsible for the formation of cleft palate and identified a new treatment to reverse this defect in mouse pups in-utero.

13 Sep 2017

LORELEI trial: Treatment with alpha specific PI3K inhibitor reduces breast tumor size

Adding taselisib to letrozole before surgery significantly improved outcomes for patients with early breast cancer that was both estrogen receptor positive and HER2-negative (ER+/HER2-) according to results of the LORELEI trial, presented at the ESMO 2017 Congress in Madrid.

8 Sep 2017

Neuroscientists discover new signaling pathway that could be good drug target to fight chronic pain

Researchers have discovered a new pain-signaling pathway in nerve cells that eventually could make a good target for new drugs to fight chronic pain.

8 Sep 2017

Researchers find signaling pathway in cells that plays key role in development of fatty liver disease

Morbid obesity affects the liver: Almost one-third of all adults suffer from chronic fatty liver disease, which can lead to infections and even trigger cancer. Researchers at the University Children's Hospital Zurich and the University of Zurich have now found a signaling pathway in cells that play an important role in the development of fatty liver disease.

7 Sep 2017

Study describes link between key melanoma signaling pathway and novel class of drugs

Results of a study by The Wistar Institute have described a correlation between a key melanoma signaling pathway and a novel class of drugs being tested in the clinic as adjuvant therapy for advanced melanoma, providing useful information for a more effective use of this type of treatment.

7 Sep 2017

Novel, ultra-rare damaging genetic variants may contribute to eating disorders

By combining whole exome sequencing, machine learning, and network analysis, researchers have identified new, ultra-rare gene mutations within specific biological pathways that may contribute to eating disorders.

5 Sep 2017

Research provides novel insights into bacterial toxins

A toxin produced by a bacterium that causes urinary tract infections is related to, yet different in key ways from, the toxin that causes whooping cough, according to new research.

5 Sep 2017

STING signaling pathway induces apoptosis in T cells

EPFL scientists show that the STING signaling pathway, which helps coordinate the innate immune system, causes cell death in T cells of the adaptive immune system. This “killing” effect includes cancerous T cells, and has implications for treating T cell-derived cancers.

5 Sep 2017

New study offers insights on mechanisms behind development of kidney damage due to obesity

A new study provides insights on the mechanisms behind the development of kidney damage due to obesity. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology, point to a potential target for protecting the kidney health of individuals with obesity.

1 Sep 2017

Fat may influence cancer development in diverse ways

Adipose tissue, or fat, may influence the development of cancer in diverse ways, depending on the type of fat and the location in the body.

1 Sep 2017

New biomedical tool using nanoparticles could improve therapies for many diseases

A new biomedical tool using nanoparticles that deliver transient gene changes to targeted cells could make therapies for a variety of diseases - including cancer, diabetes and HIV - faster and cheaper to develop, and more customizable.

30 Aug 2017

Research may lead to first-ever pharmacological treatment for rare genetic bone disease

Scientists at Children's Hospital of Philadelphia report that a drug candidate that blocks abnormal protein signals may lead to the first pharmacologic treatment for hereditary multiple exostoses (HME), a rare pediatric genetic disease.

29 Aug 2017

IBS scientists uncover key regulator of normal as well as pathological angiogenesis

New blood vessels branch out of preexisting ones is via a process called angiogenesis. Although this is essential for survival, development and wound healing, on the flip side, it also feeds and progresses malignant tumors, as well as other diseases.

29 Aug 2017

Study tests therapeutic effect of conventional and new cancer drug combinations

Cancer is one of the major causes of death worldwide affecting 8.2 million of people per year, and in the US, the number of new cases will achieve 1.6 million in 2017. The global impact of this disease costs a trillion of dollars, which makes critical the development of new drugs and treatment against it.

28 Aug 2017

Manipulation of single gene defines new pathway to mood disorders

Removing a single gene from the brains of mice and zebrafish causes these animals to become more anxious than normal.

24 Aug 2017

Study may lead to new therapy options for treatment resistant, relapsed endometrial cancer

A team of Cleveland Clinic researchers have discovered a key pathway that leads to recurrence and treatment resistance in endometrial cancer, providing the potential for much needed new therapies for women with limited options.

24 Aug 2017

Study shows role of exhausted regulatory T cells in allergic reactions

Researchers have evidence that the specialized T cells responsible for maintaining a balanced immune response are vulnerable to exhaustion that disrupts normal functioning and may even contribute to allergic reactions.

23 Aug 2017

Research identifies new gene fusions and mutations linked to GIST tumors

Researchers at UC San Diego Moores Cancer Center, with colleagues from Memorial Sloan Kettering Cancer Center and Fox Chase Cancer Center, have determined that a specific region of the small bowel, called the duodenal-jejunal flexure or DJF, shows a high frequency of gastrointestinal stromal tumors (GISTs) with mutations of the NF1 gene

18 Aug 2017

Researchers hint at experimental molecular treatment for heart failure

Researchers report encouraging preclinical results as they pursue elusive therapeutic strategies to repair scarred and poorly functioning heart tissues after cardiac injury – describing an experimental molecular treatment for heart failure.

14 Aug 2017

Study: Liver inflammation increases cholesterol levels in people with diabetes

Inflammatory processes in the liver lead to elevated cholesterol levels in people with diabetes, thus promoting subsequent vascular diseases. This is the result of a study by scientists of Helmholtz Zentrum München, Technische Universität München and the Collaborative Research Center SFB 1118 at Heidelberg University Hospital.

14 Aug 2017

Signaling Pathway News and Research

Researchers identify new in-utero treatment to reverse cleft palate in mouse models

LORELEI trial: Treatment with alpha specific PI3K inhibitor reduces breast tumor size

Neuroscientists discover new signaling pathway that could be good drug target to fight chronic pain

Researchers find signaling pathway in cells that plays key role in development of fatty liver disease

Study describes link between key melanoma signaling pathway and novel class of drugs

Novel, ultra-rare damaging genetic variants may contribute to eating disorders

Research provides novel insights into bacterial toxins

STING signaling pathway induces apoptosis in T cells

New study offers insights on mechanisms behind development of kidney damage due to obesity

Fat may influence cancer development in diverse ways

New biomedical tool using nanoparticles could improve therapies for many diseases

Research may lead to first-ever pharmacological treatment for rare genetic bone disease

IBS scientists uncover key regulator of normal as well as pathological angiogenesis

Study tests therapeutic effect of conventional and new cancer drug combinations

Manipulation of single gene defines new pathway to mood disorders

Study may lead to new therapy options for treatment resistant, relapsed endometrial cancer

Study shows role of exhausted regulatory T cells in allergic reactions

Research identifies new gene fusions and mutations linked to GIST tumors

Researchers hint at experimental molecular treatment for heart failure

Study: Liver inflammation increases cholesterol levels in people with diabetes

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News