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Arena's NDA receives Complete Response Letter for lorcaserin

Arena Pharmaceuticals, Inc. and Eisai Inc. announced that the US Food and Drug Administration (FDA) issued a Complete Response Letter (CRL) regarding Arena's New Drug Application (NDA) for lorcaserin. Lorcaserin is intended for weight management, including weight loss and maintenance of weight loss, in patients who are obese

25 Oct 2010

Motherhood helps women grow their grey matter: Study

According to the latest research motherhood helps women grow their grey matter. The study was conducted by scientists at the National Institute of Mental Health in Maryland and it showed that the brains of new mothers substantially gained in nerve cells while they coped with the steep learning curve of dealing with a newborn. Also in a bizarre way, mothers who ‘gushed’ the most about their babies showed the greatest growth in key parts of the brain.

24 Oct 2010

New findings provide new clues on pathogenetic mechanisms of Alzheimer's disease

Pathological protein deposits linked to Alzheimer's disease and cerebral amyloid angiopathy can be triggered not only by the administration of pathogenic misfolded protein fragments directly into the brain but also by peripheral administration outside the brain.

22 Oct 2010

Mount Sinai School of Medicine launches inner-city mental health program for children

Research has shown that nearly 40 percent of youth in low-income communities exhibit significant mental health needs - needs which remain largely unaddressed due to a myriad of barriers, including system-level obstacles, such as waiting lists, stigma related to seeking mental health care, poverty, family stress and competing priorities.

22 Oct 2010

Morphotek receives DOD contract to support mAb therapies against pathogenic strains

Morphotek, Inc., a subsidiary of Eisai Inc., announced today that it has been awarded a contract for $2.5 million from the U.S. Department of Defense (DOD) to support the continuing development of monoclonal antibody (mAb) therapies against staphylococcal-derived toxins and pathogenic staphylococcal strains.

22 Oct 2010

ISCTM to develop solutions for CNS clinical trial methodology

The International Society for CNS Clinical Trials and Methodology (ISCTM) met recently to develop solutions to challenges facing CNS clinical trial methodology.

21 Oct 2010

Researcher creates novel theory about chronic depression

Chronic depression is an adaptive, reparative neurobiological process gone wrong, say two University of California, San Diego School of Medicine researchers, positing in a new theory that the debilitating mental state originates from more ancient mechanisms used by the body to deal with physical injury, such as pain, tissue repair and convalescent behavior.

21 Oct 2010

Motherhood may cause brain to grow

Motherhood may actually cause the brain to grow, not turn it into mush, as some have claimed. Exploratory research published by the American Psychological Association found that the brains of new mothers bulked up in areas linked to motivation and behavior, and that mothers who gushed the most about their babies showed the greatest growth in key parts of the mid-brain.

21 Oct 2010

Automatic behaviors are stored in frontal cortex

Some people may excel at riding a bike, tying a tie, or playing the piano, but those same people may find it difficult to explain or teach those skills to someone else. These motor skills are learned in one part of the brain, whereas classroom instruction and information read in a book are acquired in another area of the brain, explained F. Gregory Ashby, professor and chair of UC Santa Barbara's Department of Psychology. This second area of learning is the frontal cortex the area immediately behind the forehead -- where executive function is located.

21 Oct 2010

Researcher hopes to provide effective medication for Parkinson's disease

The side effects of the standard medication for Parkinson's disease have long been a preoccupation of brain researchers. Now Daniella Rylander has presented new findings in a recently defended PhD thesis at Lund University that provide hope of more effective medication for those who suffer from the nerve cell disease.

21 Oct 2010

Researchers discover link between hereditary and sporadic ALS

For the first time, researchers have discovered a disease mechanism that links hereditary amyotrophic lateral sclerosis to the more common "sporadic" form of ALS and points to a possible therapeutic target.

21 Oct 2010

'Harm reduction cigarettes' more harmful

To reduce the toxicity of cigarette smoke, tobacco companies have introduced "harm reduction cigarettes," often marketed as safer than conventional brands.

21 Oct 2010

Mothers who gush about babies grow bigger brains

21 Oct 2010

Agensys and Seattle Genetics initiate ASG-5ME phase I clinical trial for castration-resistant prostate cancer

Agensys, Inc., an affiliate of Tokyo-based Astellas Pharma Inc., and Seattle Genetics, Inc. today announced that they have initiated a phase I clinical trial of ASG-5ME for the treatment of castration-resistant prostate cancer. ASG-5ME is an antibody-drug conjugate (ADC) targeting the SLC44A4 antigen and is being co-developed by both companies for the treatment of solid tumors.

21 Oct 2010

Dopamine vital for rhythmic expression in specific brain regions: Research

Daily sleeping and eating patterns are critical to human well-being and health. Now, a new study from Concordia University has demonstrated how the brain chemical dopamine regulates these cycles by altering the activity of the "clock-protein" PER2. Published in the Journal of Neuroscience, these findings may have implications for individuals with Parkinson's Disease with disrupted 24-hour rhythms of activity and sleep.

21 Oct 2010

Overweight dads may pass on diabetes to their daughters: Study

According to a latest study fathers on a high-fat diet are more likely to produce daughters with a higher diabetes risk. The study was published in the journal Nature and it involved laboratory rats.

20 Oct 2010

Abbott third quarter worldwide sales increase 11.8% to $8.7 billion

Abbott today announced financial results for the third quarter ended Sept. 30, 2010.

20 Oct 2010

A new way of seeing the world

Scientists at The Montreal Neurological Institute and Hospital - The Neuro, McGill University have discovered that our brains have the ability to determine the shape of an object simply by processing specially-coded sounds, without any visual or tactile input. Not only does this new research tell us about the plasticity of the brain and how it perceives the world around us, it also provides important new possibilities for aiding those who are blind or with impaired vision.

20 Oct 2010

Research offers important insight into symptoms of Parkinson's disease

An international collaboration led by academics at the University of Sheffield, has shed new light into Parkinson's disease, which could help with the development of cures or treatments in the future.

20 Oct 2010

Study shows impaired insulin sensitivity may serve as mediator between obesity and cognitive decline

Because of impairments in their insulin sensitivity, obese individuals demonstrate different brain responses than their normal-weight peers while completing a challenging cognitive task, according to new research by psychologists at The University of Texas at Austin.

20 Oct 2010