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Investigational Alzheimer's drug reduces molecular markers of the disease

An investigational Alzheimer's drug reduced molecular markers of disease and curbed neurodegeneration in the brain, without demonstrating evidence of cognitive benefit, in a phase 2/3 clinical trial led by researchers at Washington University School of Medicine in St. Louis through its Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU).

21 Jun 2021

New breakthrough could lead to a cure for common childhood cancer

Scientists studying a common childhood cancer have made a major breakthrough which could lead to a cure for some youngsters who would not have survived the condition.

21 Jun 2021

Multivalent antibodies show high potency against SARS-CoV-2 in new study

A new study in the journal Nature Communications describes the process of converting a SARS-CoV-2 antibody into a multivalent form, thus enabling it to bind at various different points with its epitope.

21 Jun 2021

Study reviews natural drug candidates for potential treatment of COVID-19

A recent paper in the Saudi Journal of Biological Sciences seeks to open up new approaches by reviewing a list of compounds derived from plants and other natural sources, which have potential inhibitory activity against the coronavirus.

21 Jun 2021

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

An interesting new study describes the activities of a family of viral enzymes called two-histidine-phosphoesterases (2H-PEs), found in coronaviruses (CoVs) and rotaviruses, as well as a mammalian A-kinase anchoring protein enzyme, AKAP7, that shares the same function. Together called 2’,5’-PEs, these enzymes all break down 2’,5’-oligoadenylate compounds that activate the antiviral enzyme ribonuclease L (RNase L).

21 Jun 2021

A World First: sequencing polyclonal antibodies using only proteomics

News-Medical speaks to Bin Ma, President of Rapid Novor, about their latest research that sequenced polyclonal antibodies using only proteomics.

From Rapid Novor Inc 21 Jun 2021

Research identifies SARS-CoV-2 cavities as potential drug targets

New research found the SARS-CoV-2 spike glycoprotein has druggable cavities with the best target being compatible with more than 1 billion compounds.

21 Jun 2021

Study shows that COVID-19 was present in five U.S. states in December 2019, even before the first reported case in China

In a recent study, a group of researchers aimed to identify exactly how early SARS-CoV-2 was circulating throughout the United States.

21 Jun 2021

New test is cheaper, easier, and can reliably diagnose SARS-CoV-2 infection

New lateral flow test Vigilant is cheaper, easier to use and as reliable as the current gold standard PCR test for diagnosing SARS-CoV-2 infection.

21 Jun 2021

Researchers discover genetic cause of neurodevelopmental disorder

University of Maryland School of Medicine (UMSOM) researchers identified a new gene that may be linked to certain neurodevelopmental disorders and intellectual disabilities.

21 Jun 2021

Gasdermin D plays a key role in the maturation and release of IL-1α

Interluekin-1α (IL-1α) is an important part of the immune response, but until now it has been unclear how this molecule is processed from its precursor, pro-IL-1α, and exits the cell during inflammasome activation.

21 Jun 2021

Novel interactions between proteins play a critical role in the brain injury recovery process

Patients with brain injury (caused by stroke or trauma) primarily rely on rehabilitation therapy for recovery, as there are no other known effective treatment methods. The rate of recovery from brain injury observed in adults is significantly slower (or the recovery is impossible) than that observed in young children.

21 Jun 2021

Role of tau in pathogenesis of Lewy body dementias is distinct from Alzheimer’s disease, suggests study

Will a reduction in tau protein in brain neurons protect against Parkinson's disease and Lewy body dementias?

21 Jun 2021

Study reveals the interplay between proteins that control the body's stress response

The biological mechanisms behind stress-related psychiatric conditions, including major depressive disorder and post-traumatic stress disorder (PTSD), are poorly understood.

21 Jun 2021

Study uncovers new mechanisms underlying lineage plasticity

Cancer cells have an uncanny ability to evolve and adapt to overcome the treatments used against them. While patient survival has been extended by modern drugs that block the production or action of male hormones that fuel prostate cancer -- androgen receptor inhibitors such as enzalutamide, apalutamide, darolutamide, and abiraterone -- eventually these drugs stop working.

21 Jun 2021

A new strategy to combat pathogenic bacterium

Pseudomonas aeruginosa is an opportunistic pathogenic bacterium present in many ecological niches, such as plant roots, stagnant water or even the pipes of our homes. Naturally very versatile, it can cause acute and chronic infections that are potentially fatal for people with weakened immune systems.

21 Jun 2021

Novel technique helps evaluate the effect of potential inhibitors on antibiotic-resistant bacteria

Researchers from the Miami University in Ohio have optimized a new technique that will allow scientists to evaluate how potential inhibitors work on antibiotic-resistant bacteria.

21 Jun 2021

Blocking IL-11 signaling can promote liver regeneration after paracetamol-induced damage

Scientists at Duke-NUS Medical School and National Heart Centre Singapore, in collaboration with colleagues in Singapore and the UK, have shown that the human form of the signaling protein interleukin 11 (IL-11) has a damaging effect on human liver cells--overturning a prior hypothesis that it could help livers damaged by paracetamol poisoning.

18 Jun 2021

Novel vaccine based on mRNA technology protects against malaria in animal models

Scientists from the Walter Reed Army Institute of Research and Naval Medical Research Center partnered with researchers at the University of Pennsylvania and Acuitas Therapeutics to develop a novel vaccine based on mRNA technology that protects against malaria in animal models, publishing their findings in npj Vaccines.

18 Jun 2021

Study paves the way for development of new therapeutics for C. difficile infection

A new study paves the way for the development of next generation therapeutics for the prevention and treatment of Clostridioides difficile infection (CDI), the most frequent cause of healthcare-acquired gastrointestinal infections and death in developed countries.

18 Jun 2021

Protein C News and Research

Investigational Alzheimer's drug reduces molecular markers of the disease

New breakthrough could lead to a cure for common childhood cancer

Multivalent antibodies show high potency against SARS-CoV-2 in new study

Study reviews natural drug candidates for potential treatment of COVID-19

Viral phosphoesterases (including in CoVs) can restrict antiviral innate immunity

A World First: sequencing polyclonal antibodies using only proteomics

Research identifies SARS-CoV-2 cavities as potential drug targets

Study shows that COVID-19 was present in five U.S. states in December 2019, even before the first reported case in China

New test is cheaper, easier, and can reliably diagnose SARS-CoV-2 infection

Researchers discover genetic cause of neurodevelopmental disorder

Gasdermin D plays a key role in the maturation and release of IL-1α

Novel interactions between proteins play a critical role in the brain injury recovery process

Role of tau in pathogenesis of Lewy body dementias is distinct from Alzheimer’s disease, suggests study

Study reveals the interplay between proteins that control the body's stress response

Study uncovers new mechanisms underlying lineage plasticity

A new strategy to combat pathogenic bacterium

Novel technique helps evaluate the effect of potential inhibitors on antibiotic-resistant bacteria

Blocking IL-11 signaling can promote liver regeneration after paracetamol-induced damage

Novel vaccine based on mRNA technology protects against malaria in animal models

Study paves the way for development of new therapeutics for C. difficile infection

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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