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Novel strategies on the way for difficult-to-treat head and neck cancer

Novel strategies are on the way for difficult-to-treat and advanced head and neck cancer, the most heterogeneous group of malignancies which are generally associated with poor survival, and encouraging results have been presented at the first ESMO Asia 2015 Congress in Singapore.

17 Dec 2015

AGA issues six new clinical practice guidelines

In 2015, the American Gastroenterological Association issued six clinical practice guidelines, all published in AGA's official journal Gastroenterology, offering current, evidence-based point-of-care recommendations to guide physicians at the bedside.

17 Dec 2015

Berkeley Lab researchers develop new mouse model for most common form of breast cancer

The first clinically-relevant mouse model of human breast cancer to successfully express functional estrogen receptor positive (ER+) adenocarcinomas has been developed by researchers at Lawrence Berkeley National Laboratory.

17 Dec 2015

Soligenix reports positive results from SGX942 Phase 2 trial in patients with head and neck cancer

Soligenix, Inc., a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need, announced today positive results in its Phase 2 clinical trial, in which SGX942, a first-in-class Innate Defense Regulator (IDR), at a dose of 1.5 mg/kg, successfully reduced the median duration of severe oral mucositis by 50% in all patients and by 67% in patients receiving the most aggressive chemoradiation therapy (CRT) for treatment of their head and neck cancer.

16 Dec 2015

Study offers new view of how cancer cells transform normal cells through 'metastatic hijacking'

Metastasis - or the spread of cancer from one part of the body to other parts - accounts for more than 90 percent of cancer-related deaths. Although the cells that seed metastasis and the sites that they tend to travel to have been increasingly studied over the years, little has been known about how cancer migrates from a primary site, such as breast tissue, to a secondary site, such as the brain or bone marrow.

16 Dec 2015

Study paves way for development of novel cancer therapeutics

A team of scientists, comprising researchers from the Institute of Molecular and Cell Biology, a research institute under the Agency for Science, Technology and Research, Singapore, and the VIB Laboratory of Molecular Cancer Biology, has revealed the mechanism by which tumor cells elevate levels of MDM4, a protein that is highly expressed in cancer cells but not in normal adult tissues.

16 Dec 2015

Use of tumor-treating fields along with chemotherapy improves survival in patients with brain tumor

Early research indicates that the use of tumor-treating fields, a type of electromagnetic field therapy, along with chemotherapy in patients with a brain tumor who had completed standard chemoradiation resulted in prolonged progression-free and overall survival, according to a study in the December 15 issue of JAMA.

16 Dec 2015

Cancer drug may protect kidneys from damage caused by chemotherapy agent cisplatin

A class of drugs used increasingly to help fight cancer may have the additional benefit of protecting the kidneys when packaged with the powerful chemotherapy agent cisplatin.

16 Dec 2015

Discovery could pave way for targeted therapies to treat penile cancer

Researchers have identified potential genetic alterations in penile cancer that could pave the way for targeted treatments.

15 Dec 2015

Experimental drugs that modify cell metabolism also halt tumor growth

Experimental drugs that alter cell metabolism also halted tumor growth and extended survival in mice with cancers linked to changes in the same gene, according to a new study led by researchers at NYU Langone Medical Center, its Laura and Isaac Perlmutter Cancer Center and Massachusetts General Hospital.

15 Dec 2015

New study describes a way to identify complex type of mutation in cancer genomes

New research shows that current approaches to genome analysis systematically miss detecting a certain type of complex mutation in cancer patients' tumors. Further, a significant percentage of these complex mutations are found in well-known cancer genes that could be targeted by existing drugs, potentially expanding the number of cancer patients who may benefit.

15 Dec 2015

Researchers discover first broad spectrum drug that can potently kill aging cells in culture

Researchers from the University of Arkansas for Medical Sciences and other institutions are reporting the discovery of the first broad spectrum drug that can potently kill senescent (or aging) cells in culture and effectively clear the cells in animals by specifically targeting a pathway that is critical for the survival of senescent cells.

15 Dec 2015

ImmunoCellular partners with CBTC for ICT-107 phase 3 registrational trial in patients with glioblastoma

ImmunoCellular Therapeutics, Ltd. today announced the establishment of an agreement with a major Canadian cancer cooperative group, The Canadian Brain Tumour Consortium, for the phase 3 registrational trial of its cancer immunotherapy ICT-107 in patients with newly diagnosed glioblastoma.

14 Dec 2015

Complix signs agreement with Selexis to advance production of autoimmune drug candidate CMX-02

Complix NV, a biopharmaceutical company developing a pipeline of transformative protein therapeutics, called Alphabodies, for the treatment of cancer and severe autoimmune diseases, announces that it is advancing the development of CMX-02, a potential treatment of severe autoimmune disease.

14 Dec 2015

BTG receives 510k clearance for LC Bead LUMI

BTG plc, a global specialist healthcare company, today announced it has received 510k clearance from the US Food and Drug Administration for LC Bead LUMI, the first commercially available radiopaque embolic bead for the embolization of hypervascular tumors and arteriovenous malformations (AVMs).

14 Dec 2015

Innovative Phase II trial evaluates effectiveness of diabetes medication for lymphoma

Cancer, it could be said, grows like a weed: rapidly, invasively, and with devastating impact on the place it infests. Also like a weed, cancer can't grow on its own — it needs nourishment, which it drains from the human body, just as weeds take nutrients in the soil away from other plants.

13 Dec 2015

ICGC article lays foundation for the coming era of cancer genomic research

An eye-opening article from the International Cancer Genome Consortium was published today in the prestigious journal Nature Communications. It lays a foundation for the coming era of research in cancer genomics.

13 Dec 2015

Rutgers scientists uncover biological pathways that provide insight into tiny cell bubbles

Rutgers scientists have uncovered biological pathways in the roundworm that provide insight into how tiny bubbles released by cells can have beneficial health effects, like promoting tissue repair, or may play a diabolical role and carry disease signals for cancer or neurodegenerative diseases like Alzheimer's.

12 Dec 2015

Combination treatment provides effective one-two punch against prostate cancer

Results from a long-term clinical trial conducted by cancer researchers at Houston Methodist Hospital show that combining radiation treatment with "suicide gene therapy," a technique in which prostate cancer cells are genetically modified so they signal a patient's immune system to attack them, provides a safe and effective one-two punch against the disease.

12 Dec 2015

New MSK-led studies on liquid biopsy presented at San Antonio Breast Cancer Symposium

Information gleaned from a liquid biopsy may help predict how individual women with advanced breast cancer will respond to certain therapies as well as reveal genetic mutations that can impact prognosis, according to two new studies led by Memorial Sloan Kettering Cancer Center Physician-in-Chief José Baselga and physician-scientist Sarat Chandarlapaty.

12 Dec 2015

Tumor News and Research

Novel strategies on the way for difficult-to-treat head and neck cancer

AGA issues six new clinical practice guidelines

Berkeley Lab researchers develop new mouse model for most common form of breast cancer

Soligenix reports positive results from SGX942 Phase 2 trial in patients with head and neck cancer

Study offers new view of how cancer cells transform normal cells through 'metastatic hijacking'

Study paves way for development of novel cancer therapeutics

Use of tumor-treating fields along with chemotherapy improves survival in patients with brain tumor

Cancer drug may protect kidneys from damage caused by chemotherapy agent cisplatin

Discovery could pave way for targeted therapies to treat penile cancer

Experimental drugs that modify cell metabolism also halt tumor growth

New study describes a way to identify complex type of mutation in cancer genomes

Researchers discover first broad spectrum drug that can potently kill aging cells in culture

ImmunoCellular partners with CBTC for ICT-107 phase 3 registrational trial in patients with glioblastoma

Complix signs agreement with Selexis to advance production of autoimmune drug candidate CMX-02

BTG receives 510k clearance for LC Bead LUMI

Innovative Phase II trial evaluates effectiveness of diabetes medication for lymphoma

ICGC article lays foundation for the coming era of cancer genomic research

Rutgers scientists uncover biological pathways that provide insight into tiny cell bubbles

Combination treatment provides effective one-two punch against prostate cancer

New MSK-led studies on liquid biopsy presented at San Antonio Breast Cancer Symposium

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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