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Immune cell-mimicking nanoparticles deliver drugs directly to inflamed lungs

Nanoengineers at the University of California San Diego have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they're needed. As a proof of concept, the researchers filled the nanoparticles with the drug dexamethasone and administered them to mice with inflamed lung tissue.

17 Jun 2021

New study may lead to more effective and powerful COVID-19 vaccines

A new study looking at the way human cells activate the immune system in response to SARS-CoV-2 infection could open the door to even more effective and powerful vaccines against the coronavirus and its rapidly emerging variants keeping the global pandemic smoldering.

17 Jun 2021

Scientists decipher the activation mechanism of a chemokine receptor

Chemokine receptors, located at the surface of many immune cells, play an important role in their function. Chemokines are small proteins that bind to these receptors and control the movement and behavior of white blood cells.

16 Jun 2021

Corticosteroids may effectively treat children who develop a serious disorder after COVID-19

Corticosteroids may be an effective treatment for children who develop a rare but serious condition after COVID-19 infection.

16 Jun 2021

Researchers identify properties that enable proteins to remember and respond to pressure

A new rubber band stretches, but then snaps back into its original shape and size. Stretched again, it does the same. But what if the rubber band was made of a material that remembered how it had been stretched? Just as our bones strengthen in response to impact, medical implants or prosthetics composed of such a material could adjust to environmental pressures such as those encountered in strenuous exercise.

16 Jun 2021

Study finds molecular switch that controls the ability of organisms to adapt to low nutrient levels

Getting energy and nutrients from the environment - that is, eating - is such an important function that it has been regulated through sophisticated mechanisms over hundreds of millions of years. Some of these mechanisms are only now beginning to be unraveled.

16 Jun 2021

'Wonder material' used to detect SARS-CoV-2 virus in laboratory experiments

Researchers at the University of Illinois Chicago have successfully used graphene -- one of the strongest, thinnest known materials -- to detect the SARS-CoV-2 virus in laboratory experiments.

16 Jun 2021

Using natural killers from the immune system to target breast cancer cells

It sounds like a plot from a Quentin Tarantino movie -- something sets off natural killers and sends them on a killing spree.

16 Jun 2021

P-glycoprotein shows ability to remove a toxin associated with Alzheimer's from the brain

\A team of SMU biological scientists has confirmed that P-glycoprotein (P-gp) has the ability to remove a toxin from the brain that is associated with Alzheimer's disease.

16 Jun 2021

Scientists capture real-time electrical activity of a beating heart using graphene 'camera'

Bay Area scientists have captured the real-time electrical activity of a beating heart, using a sheet of graphene to record an optical image -- almost like a video camera -- of the faint electric fields generated by the rhythmic firing of the heart's muscle cells.

16 Jun 2021

Study reveals structural details of omega-3 fatty acid transport across the blood–brain barrier

Spectacular images of a molecule that shuttles omega-3 fatty acids into the brain may open a doorway for delivering neurological therapeutics to the brain.

16 Jun 2021

$1 million grant awarded to eliminate the need for drug refrigeration

COVID-19 vaccines have been tested, validated and administered to millions of people around the world. But in some countries, the vaccines have yet to arrive in great enough numbers.

16 Jun 2021

New computational topology strategy to identify existing medicines for treating COVID-19

Researchers from the ESI International Chair of the CEU Cardenal Herrera University (CEU UCH) and ESI Group have just published in scientific journal Pharmaceutics a new computational topology strategy to identify existing medicines that could be applied to treat COVID-19 without waiting for the research and clinical trial phases required to develop a new medicine.

16 Jun 2021

Scientists reveal the mechanism of liquid-liquid phase separation of SARS-CoV-2 nucleocapsid

A team of scientists from the United States has recently revealed how interactions between the SARS-CoV-2 nucleocapsid protein and the double-stranded RNA motifs impart distinct droplet properties that can support multiple viral functions. The study is currently available on the bioRxiv* preprint server.

16 Jun 2021

Gut microbiome impacts stroke severity and post-stroke functional impairment

New findings from Cleveland Clinic researchers show for the first time that the gut microbiome impacts stroke severity and functional impairment following stroke.

16 Jun 2021

Reducing coronavirus-related mortality through senolytics

A study recently published in the journal Science explores the concept of senescent cells (SnC) having a hyperinflammatory response and the use of a class of small molecules called senolytics to combat this.

16 Jun 2021

Researchers demonstrate a potentially powerful strategy for treating cystic fibrosis

UNC School of Medicine scientists led a collaboration of researchers to demonstrate a potentially powerful new strategy for treating cystic fibrosis (CF) and potentially a wide range of other diseases.

16 Jun 2021

COVID-e-Vax DNA vaccine candidate elicits robust immune responses in preclinical trials

A new study, released as a preprint on the bioRxiv* server, describes the late-stage clinical trial efficacy of a new vaccine candidate based on a deoxyribonucleic acid (DNA) plasmid platform expressing the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. Among different constructs of the vaccine plasmid, the RBD was found to produce the most potent and broad immune response.

16 Jun 2021

Study observes increased breadth of SARS-CoV-2 antibody neutralization acquired over one year

A new paper in the journal Nature offers a reassuring answer, showing that convalescent COVID-19 patients, some of whom had received vaccination as well, retain antiviral antibodies and neutralizing activity, as well as memory B cells, for up to 6-12 months from infection.

16 Jun 2021

Anti-viral treatment can stop the spread of lab modeled SARS-CoV-2 by 99.5%

A new approach focusing on cellular repair may be an effective strategy to address the pandemic.

16 Jun 2021

Protein C News and Research

Immune cell-mimicking nanoparticles deliver drugs directly to inflamed lungs

New study may lead to more effective and powerful COVID-19 vaccines

Scientists decipher the activation mechanism of a chemokine receptor

Corticosteroids may effectively treat children who develop a serious disorder after COVID-19

Researchers identify properties that enable proteins to remember and respond to pressure

Study finds molecular switch that controls the ability of organisms to adapt to low nutrient levels

'Wonder material' used to detect SARS-CoV-2 virus in laboratory experiments

Using natural killers from the immune system to target breast cancer cells

P-glycoprotein shows ability to remove a toxin associated with Alzheimer's from the brain

Scientists capture real-time electrical activity of a beating heart using graphene 'camera'

Study reveals structural details of omega-3 fatty acid transport across the blood–brain barrier

$1 million grant awarded to eliminate the need for drug refrigeration

New computational topology strategy to identify existing medicines for treating COVID-19

Scientists reveal the mechanism of liquid-liquid phase separation of SARS-CoV-2 nucleocapsid

Gut microbiome impacts stroke severity and post-stroke functional impairment

Reducing coronavirus-related mortality through senolytics

Researchers demonstrate a potentially powerful strategy for treating cystic fibrosis

COVID-e-Vax DNA vaccine candidate elicits robust immune responses in preclinical trials

Study observes increased breadth of SARS-CoV-2 antibody neutralization acquired over one year

Anti-viral treatment can stop the spread of lab modeled SARS-CoV-2 by 99.5%

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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