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Scientists succeed to control cells' behavior using light

Scientists at Washington University School of Medicine in St. Louis have shown they can coax cells to move toward a beam of light. The feat is a first step toward manipulating cells to control insulin secretion or heart rate using light.

9 Apr 2013

American Cancer Society announces new research, training grants for fiscal year 2013

The American Cancer Society, the largest non-government, not-for-profit funding source of cancer research in the United States, has awarded 175 national research and training grants totaling $79,073,250 for fiscal year 2013.

9 Apr 2013

Certain brain tumors develop drug resistance by exploiting normal cellular signaling pathways

Proteins that control cell growth are often mutated in cancer, and their aberrant signaling drives the wild proliferation of cells that gives rise to tumors.

9 Apr 2013

ISP of Chile approves Trigemina's protocol for Phase 2 clinical study of TI-001

Trigemina, Inc., a biopharmaceutical company focused on the discovery and development of non-narcotic, nasally delivered, analgesic drug products, today announced that the Instituto de Salud Publica of Chile has approved the Company's protocol for its Phase 2 clinical study of TI-001, intranasal oxytocin, for the treatment of chronic migraine.

9 Apr 2013

Study sheds light on role of retinoic acid in tissue development

In a ground-breaking study, researchers from the RIKEN Brain Science Institute in Japan report a new technique that allows them to visualize the distribution of retinoic acid in a live zebrafish embryo, in real-time.

9 Apr 2013

Study offers new insights into how nervous system processes hot and cold temperatures

A study from the University of North Carolina School of Medicine offers new insights into how the nervous system processes hot and cold temperatures. The research led by neuroscientist Mark J. Zylka, PhD, associate professor of cell biology and physiology, found an interaction between the neural circuits that detect hot and cold stimuli: cold perception is enhanced when nerve circuitry for heat is inactivated.

9 Apr 2013

MIT researchers present novel approach to develop dengue therapy using mutated antibodies

Nearly half of the world's population is at risk of infection by the dengue virus, yet there is no specific treatment for the disease. Now a therapy to protect people from the virus could finally be a step closer, thanks to a team at MIT.

9 Apr 2013

Nektar Therapeutics presents positive results for NKTR-214 at AACR Annual Meeting

Nektar Therapeutics today presented positive preclinical data for NKTR-214, a novel cancer immunotherapy which targets the IL-2 receptor complex, at the 2013 American Association for Cancer Research Annual Meeting.

8 Apr 2013

Heart, blood and lungs have same receptors for sensing odors that exist in nose

In a discovery suggesting that odors may have a far more important role in life than previously believed, scientists have found that heart, blood, lung and other cells in the body have the same receptors for sensing odors that exist in the nose.

8 Apr 2013

Dual-signaling CAR T cells show potent anti-cancer activity in animal model

The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs.

8 Apr 2013

National Jewish Health researchers unravel mystery of adjuvants

Aluminum salts, or alum, have been injected into billions of people as an adjuvant to make vaccines more effective.

8 Apr 2013

Researchers discover new molecular mechanism to prevent edema formation

Researchers of the Max Delbr-ck Center for Molecular Medicine and the Leibniz Institute of Molecular Pharmacology in Berlin-Buch, Germany, have now detected a substance that can prevent the accumulation of fluid in body tissue and thus edema formation.

8 Apr 2013

Arena Pharmaceuticals kicks off APD334 Phase 1 clinical trial for treatment of autoimmune diseases

Arena Pharmaceuticals, Inc. announced today the initiation of dosing in a Phase 1 clinical trial of APD334, a novel oral drug candidate that targets the sphingosine 1-phosphate subtype 1 (S1P1) receptor for the potential treatment of autoimmune diseases.

6 Apr 2013

Nobel Prize recipient describes on innate immunity at Annual Drosophila Research Conference

A young scientist's astute observation - that grasshoppers don't get sick - eventually led to profound insights into our own immunity.

6 Apr 2013

Penn Medicine scientist, trial participant detail experiences on leading edge of gene therapy

Harnessing the patient's own immune system to fight cancer through genetic modification of their own cells is rapidly emerging as a promising treatment option.

6 Apr 2013

Not all mice that come into contact with Borrelia contract Lyme disease, study finds

Like humans, mice can become infected with Borrelia. However, not all mice that come into contact with these bacteria contract the dreaded Lyme disease: Animals with a particular gene variant are immune to the bacteria, as scientists from the universities of Zurich and Lund demonstrate.

5 Apr 2013

One cohort of Phase 2 NSCLC study fails to meet primary endpoint, Merrimack says

Merrimack Pharmaceuticals, Inc. today announced that one cohort of a Phase 2 non-small cell lung cancer study did not meet its primary endpoint. The cohort evaluated MM-121 in combination with erlotinib to treat patients with NSCLC whose disease progressed on an anti-EGFR tyrosine kinase inhibitor (EGFR-TKI).

5 Apr 2013

TSRI scientists identify new drugs for human prion disease

Human diseases caused by misfolded proteins known as prions are some of most rare yet terrifying on the planet—incurable with disturbing symptoms that include dementia, personality shifts, hallucinations and coordination problems.

4 Apr 2013

Tris Pharma gets FDA NDA approval for Karbinal ER Extended-release Oral Suspension

Tris Pharma, a specialty pharmaceutical company focused on developing innovative drug delivery technologies, today announced that the U.S. Food and Drug Administration has approved its New Drug Application for Karbinal ER (carbinoxamine maleate) Extended-release Oral Suspension 4mg/5ml, the first sustained-release histamine receptor blocking agent indicated for the treatment of seasonal and perennial allergic rhinitis in children ages 2 and up.

4 Apr 2013

Targeting cholesterol metabolism in eye may prevent age-related macular degeneration, says study

Targeting cholesterol metabolism in the eye might help prevent a severe form of age-related macular degeneration (AMD), one of the most common causes of blindness in older Americans, according to indications in a study in mice, which was supported by the National Institutes of Health.

3 Apr 2013

Receptor News and Research

Scientists succeed to control cells' behavior using light

American Cancer Society announces new research, training grants for fiscal year 2013

Certain brain tumors develop drug resistance by exploiting normal cellular signaling pathways

ISP of Chile approves Trigemina's protocol for Phase 2 clinical study of TI-001

Study sheds light on role of retinoic acid in tissue development

Study offers new insights into how nervous system processes hot and cold temperatures

MIT researchers present novel approach to develop dengue therapy using mutated antibodies

Nektar Therapeutics presents positive results for NKTR-214 at AACR Annual Meeting

Heart, blood and lungs have same receptors for sensing odors that exist in nose

Dual-signaling CAR T cells show potent anti-cancer activity in animal model

National Jewish Health researchers unravel mystery of adjuvants

Researchers discover new molecular mechanism to prevent edema formation

Arena Pharmaceuticals kicks off APD334 Phase 1 clinical trial for treatment of autoimmune diseases

Nobel Prize recipient describes on innate immunity at Annual Drosophila Research Conference

Penn Medicine scientist, trial participant detail experiences on leading edge of gene therapy

Not all mice that come into contact with Borrelia contract Lyme disease, study finds

One cohort of Phase 2 NSCLC study fails to meet primary endpoint, Merrimack says

TSRI scientists identify new drugs for human prion disease

Tris Pharma gets FDA NDA approval for Karbinal ER Extended-release Oral Suspension

Targeting cholesterol metabolism in eye may prevent age-related macular degeneration, says study

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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