Hypothalamus News and Research

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The Hypothalamus is the area of the brain that controls body temperature, hunger, and thirst.

Gut bacteria influence symptoms of hypopituitarism in mice

Researchers at the Francis Crick Institute have shown that the balance of bacteria in the gut can influence symptoms of hypopituitarism in mice.

26 Sep 2024

Researchers gain new understanding of how immune cells respond to heat during fever

The study reveals that moderate fever enhances CD4 T cell activity while reducing regulatory T cell suppression, highlighting temperature's immune effects.

25 Sep 2024

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Researchers have discovered that remodeling of extracellular matrix (ECM) in the hypothalamus, specifically around AgRP neurons, drives insulin resistance and metabolic disease. Disrupting this ECM buildup improves insulin sensitivity and may be a promising treatment for obesity and diabetes.

19 Sep 2024

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity and metabolic disease treatment.

19 Sep 2024

Study reveals sequential neuronal activation regulating food intake

The process of food intake appears to be organized at the cellular level like a relay race: during eating, the baton is passed between different teams of neurons until we have consumed the appropriate amount of energy.

17 Sep 2024

GLP-2 regulates appetite by influencing gut-brain communication and gastrointestinal motility

Researchers examine the role of GLP-2 in regulating food intake through its effects on gastrointestinal motility and satiety signals, offering insights into potential obesity treatments.

12 Sep 2024

Girls exposed to endocrine-disrupting chemicals may be more likely to start puberty early

Girls exposed to certain endocrine-disrupting chemicals (EDCs) may be more likely to start puberty early, according to new research published in Endocrinology, the flagship basic science journal of the Endocrine Society.

10 Sep 2024

Study finds clinical hypnosis more effective than cognitive behavioral therapy for hot flashes

Nonhormone options for hot flashes and other menopause symptoms are growing in popularity, especially for women who cannot take hormones due to health complications. Cognitive behavioral therapy and clinical hypnosis are common nonhormone treatment options.

10 Sep 2024

Exploring the impact of thyroid hormone on brain function

Thyroid hormone plays a key role in regulating a range of physiologic functions, including metabolism, temperature, heart rate, and growth. It accomplishes this impressive array of activities by interacting with almost every organ system in the body. Yet despite a long history of research on how thyroid hormone influences different organs, its effects on arguably the most crucial organ - the brain - have remained shrouded in mystery.

23 Aug 2024

Breakthrough compound targets appetite and tau protein in obesity and Alzheimer's

Scientists on the team of Dr Lenka Maletínská have developed a promising new compound derived from one of the peptides naturally occurring in the brain.

21 Aug 2024

Calorie restriction and therapy combo reshapes gut microbiome, boosts mental health in women

Study finds that combining caloric restriction with psychological interventions significantly alters the gut microbiome and improves stress-related mental health in women.

11 Aug 2024

Study identifies brain circuit that balances hunger-driven and pleasure-driven eating

People eat either because they are hungry or for pleasure, even in the absence of hunger. While hunger-driven eating is fundamental for survival, pleasure-driven feeding may accelerate the onset of obesity and associated metabolic disorders.

9 Aug 2024

Study reveals key brain cells help resist food temptations in favor of exercise

Hypocretin/orexin neurons (HONs) are crucial for resisting temptation and choosing exercise over highly palatable foods. This finding highlights potential targets for promoting physical activity and combating obesity.

7 Aug 2024

Dopamine treatment can reduce Alzheimer's plaques and improve memory

A new way to combat Alzheimer's disease has been discovered by Takaomi Saido and his team at the RIKEN Center for Brain Science (CBS) in Japan.

6 Aug 2024

Menopause myths: Separating fact from fiction

Many women approach menopause with anxiety about the future. You've probably heard your grandmother, mother, or aunts lament about menopause, aka "the change," as a stressful time full of hot flashes, weight gain, and plummeting sex drive.

6 Aug 2024

New AI method accurately predicts male infertility from hormone levels, bypassing need for semen analysis

Study investigates the accuracy of an AI screening method for male infertility based on serum hormone levels, offering a non-invasive alternative to traditional semen analysis.

4 Aug 2024

Epigenetic reprogramming and hypothalamic changes in metabolic syndrome

Metabolic syndrome (MetS) is a multifaceted disorder that impacts approximately 20–25% of the global population.

30 Jul 2024

Exercise boosts hormone levels: New research shows increased oxytocin and cortisol in urine and saliva

Research shows that both urine and saliva samples effectively capture oxytocin and cortisol fluctuations in response to physical exercise, highlighting the robustness of these non-invasive methods.

22 Jul 2024

SH2B1 gene defends against obesity via the paraventricular hypothalamus

Obesity is a complicated condition, caused by a combination of genetics, the food environment, behavior, and other factors.

15 Jul 2024

New brain targets for GLP1-based obesity drugs may reduce weight without nausea

Researchers identified distinct hindbrain GLP1R neurons driving satiety and aversion, offering new targets for effective, side-effect-free obesity treatments.

14 Jul 2024