Lysosomes News and Research

RSS

Machine learning can accurately predict subtypes of Parkinson's disease

Researchers at the Francis Crick Institute and UCL Queen Square Institute of Neurology, working with technology company Faculty AI, have shown that machine learning can accurately predict subtypes of Parkinson's disease using images of patient-derived stem cells.

10 Aug 2023

How conversion between different types of cell death contributes to disease

Researchers elucidate the role of cell death in the pathogenesis of different diseases.

10 Aug 2023

Nanotechnology's triple threat: Advancing precision cancer treatment

The design of tumor tissue-, cell-, and organelle-targeted cancer nanomedicines.

9 Aug 2023

New protein discovered in Alzheimer's brains could lead to better diagnosis and treatment

Alzheimer's is considered a disease of old age, with most people being diagnosed after 65. But the condition actually begins developing out of sight many years before any symptoms emerge.

19 Jul 2023

Northwestern Medicine scientists discover new therapeutic target for Parkinson’s disease

Northwestern Medicine scientists have uncovered a new mechanism by which mutations in a gene parkin contribute to familial forms of Parkinson's disease.

19 Jul 2023

Insilico Medicine and MIKADO team up to find new treatments for cystinosis

A team led by researchers at the Mechanisms of Inherited Kidney Disorders (MIKADO) group at the University of Zurich (Zurich, Switzerland) has used Insilico Medicine's generative artificial intelligence (AI) target discovery engine, PandaOmics, to identify actionable drug targets for the lysosomal storage disease cystinosis and to validate them in preclinical models of the disease.

14 Jul 2023

AI-powered drug discovery offers hope for cystinosis patients

Artificial intelligence is becoming increasingly important in drug discovery. Advances in the use of Big Data, learning algorithms and powerful computers have now enabled researchers at the University of Zurich (UZH) to better understand a serious metabolic disease.

14 Jul 2023

Scientists discover new mechanism for kidney cell renewal

University of Texas at Dallas scientists have discovered a previously unknown "housekeeping" process in kidney cells that ejects unwanted content, resulting in cells that rejuvenate themselves and remain functioning and healthy.

14 Jul 2023

Study provides insights into the molecular mechanism of Batten disease

Neuronal Ceroid Lipofuscinosis are a group of devastating neurodegenerative lysosomal storage disorders that begin in childhood. Mutations in CLN3 gene lead to a NCL called Batten disease, characterized by the progressive loss of vision, movement, and cognition.

6 Jul 2023

RNA plays a role in regulating cell fate in the early mouse embryo

The early stages of embryonic development contain many of life's mysteries. Unlocking these mysteries can help us better understand early development and birth defects, and help develop new regenerative medicine treatments.

30 May 2023

Study highlights two strategies used by Salmonella to escape the human body's defenses

Like thieves that constantly look for ways to evade capture, Salmonella enterica, a disease-causing bacterium, uses various tactics to escape the human body's defence mechanisms.

26 May 2023

Extracellular chaperones mediate the lysosomal degradation of misfolded proteins

When exposed to stressful conditions, several proteins tend to misfold and form aggregates inside or outside cells.

11 May 2023

Novel fluorescent probe reveals constant conversion rate of endolysosomes

Collaborative research at the University of Cincinnati has developed a new probe to better study cells that has already led to new knowledge about certain cellular processes.

9 May 2023

UC-led research team receives NIH grant to study the role of an enzyme in lysosome function

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes.

11 Apr 2023

Broccoli intake protects the small intestine lining, inhibits development of disease

Broccoli is known to be beneficial to our health. For example, research has shown that increased consumption of the cruciferous vegetable decreases incidences of cancer and type 2 diabetes.

6 Apr 2023

Scientists unearth some of the biological mechanisms behind ferroptosis

A team of researchers at Tohoku University has unearthed some of the biological mechanisms of ferroptosis, a recently discovered type of regulated cell death that is triggered by iron and the accumulation of lipid peroxidation - lipids that have undergone oxidative degeneration.

5 Apr 2023

Structure of cellular shredders varies according to cell type, study shows

"Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required.

16 Mar 2023

Gut dysbiosis and sepsis susceptibility among pregnant women

Researchers describe the role of gut dysbiosis during pregnancy in promoting excessive macrophage pyroptosis, which increases vulnerability to sepsis.

19 Feb 2023

Study shows activation of pulmonary macrophages by SARS-CoV-2 spike glycoprotein

In a recent study published in the International Journal of Molecular Sciences, researchers investigated the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein on human lung macrophage (HLM) activation and angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) expression in human lung macrophages.

7 Feb 2023

Understanding the mechanisms involved in heart disease and cancers

In a crucial step towards understanding the mechanisms involved in cardiovascular disease and certain cancers, a Canadian led research team has succeeded in a world first: they've found the molecular mechanism by which the protein PCSK9 degrades the receptor of low density lipoproteins, the richest cholesterol particles in the bloodstream.

19 Jan 2023

Lysosomes News and Research

Machine learning can accurately predict subtypes of Parkinson's disease

How conversion between different types of cell death contributes to disease

Nanotechnology's triple threat: Advancing precision cancer treatment

New protein discovered in Alzheimer's brains could lead to better diagnosis and treatment

Northwestern Medicine scientists discover new therapeutic target for Parkinson’s disease

Insilico Medicine and MIKADO team up to find new treatments for cystinosis

AI-powered drug discovery offers hope for cystinosis patients

Scientists discover new mechanism for kidney cell renewal

Study provides insights into the molecular mechanism of Batten disease

RNA plays a role in regulating cell fate in the early mouse embryo

Study highlights two strategies used by Salmonella to escape the human body's defenses

Extracellular chaperones mediate the lysosomal degradation of misfolded proteins

Novel fluorescent probe reveals constant conversion rate of endolysosomes

UC-led research team receives NIH grant to study the role of an enzyme in lysosome function

Broccoli intake protects the small intestine lining, inhibits development of disease

Scientists unearth some of the biological mechanisms behind ferroptosis

Structure of cellular shredders varies according to cell type, study shows

Gut dysbiosis and sepsis susceptibility among pregnant women

Study shows activation of pulmonary macrophages by SARS-CoV-2 spike glycoprotein

Understanding the mechanisms involved in heart disease and cancers

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Applications Engineer

Latest News