Muscle Wasting News and Research

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UCLA researchers discover compound that stimulates muscle cells in mice

UCLA researchers have identified a compound that can reproduce the effect of exercise in muscle cells in mice. The findings are published in the journal Cell Reports Medicine.

21 Oct 2020

Serious ongoing symptoms in COVID-19 survivors

Although predominantly a respiratory illness, emerging data suggests that multi-organ injury is common, particularly in moderate to severe infections. A new study published on the preprint server medRxiv* in October 2020 describes the illness's sequelae in the months after recovery.

20 Oct 2020

Study offers renewed hope for children suffering from myofibrillar myopathies

Stephen Greenspan and Laura Zah were devastated when they learned their son Alexander had a rare genetic mutation, which causes a deadly neuromuscular disease with no known treatment or cure.

14 Oct 2020

Neurobiologists decode central mechanism of degenerative processes in brains of mouse models

Heidelberg neurobiologists decode central mechanism of degenerative processes in the brains of mouse models and develop new principle for therapeutic agents

9 Oct 2020

NIH awards grants for using bioengineered models to improve clinical trial design

Clinical Trials on a Chip researchers plan to build and test common and rare disease models to help improve the clinical trial process.

30 Sep 2020

Study uncovers a promising new therapeutic approach for Duchenne muscular dystrophy

Scientists at Sanford Burnham Prebys Medical Discovery Institute, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring (fibrosis).

15 Sep 2020

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Myotonic dystrophy type I is the most common type of adult-onset muscular dystrophy. People with the condition inherit repeated DNA segments that lead to the toxic buildup of repetitive RNA, the messenger that carries a gene's recipe to the cell's protein-making machinery.

14 Sep 2020

Ghrelin may help protect the elderly population from muscle loss

The hormone, ghrelin, may help protect the elderly population from muscle loss, according to a study being presented at e-ECE 2020. The study found that administering a particular form of ghrelin to older mice helped to restore muscle mass and strength.

8 Sep 2020

FDA approves first oral drug for treatment of spinal muscular atrophy

The U.S. Food and Drug Administration today approved Evrysdi (risdiplam) to treat patients two months of age and older with spinal muscular atrophy (SMA), a rare and often fatal genetic disease affecting muscle strength and movement.

7 Aug 2020

Buck researchers investigate ketone bodies as possible therapeutic against COVID-19

Given the disproportionate impact that COVID-19 has on older adults in terms of death and lasting disability, and the impact of common aging-related comorbidities like diabetes and cardiovascular disease, Buck Institute professor and practicing geriatrician John Newman, MD, PhD, can make a compelling argument that those infected with the SARS-CoV2 virus are suffering from an aging-related disease, no matter how old they are when they get infected.

15 Jul 2020

The Role of Nutrition in Recovery from COVID-19

Dr. Riccardo Caccialanza speaks to News-Medical about how implementing nutritional support can make a significant difference to COVID-19 patient recovery time.

24 Jun 2020

Diluting blood plasma helps achieve age-reversing effects in mice

In 2005, University of California, Berkeley, researchers made the surprising discovery that making conjoined twins out of young and old mice -- such that they share blood and organs -- can rejuvenate tissues and reverse the signs of aging in the old mice.

15 Jun 2020

Activating specific brain cells can trigger hibernation-like state in mice

In Sci-Fi movies, astronauts often enter an inactive state in "hibernation chambers" to cross the vastness of space.

12 Jun 2020

Scientists identify key cell signaling pathway that drives muscle loss

Researchers at the University of Nebraska Medical Center have identified a key cell signaling pathway that drives the devastating muscle loss, or cachexia, suffered by many cancer patients.

22 May 2020

Researchers establish a gene expression profile associated with cachexia in cancer patients

It is estimated that as many as 80% of advanced-stage cancer patients may develop cachexia, a potentially fatal metabolic syndrome characterized by extreme weight loss and muscle wasting, but scientists do not yet fully understand why it is more frequently associated with certain kinds of tumor than others, or why not all cancer patients develop it.

3 Mar 2020

Researchers discover glial cells that control stress response, extend lifespan in worms

While many of us worry about proteins aggregating in our brains as we age and potentially causing Alzheimer's disease or other types of neurodegeneration, we may not realize that some of the same proteins are aggregating in our muscles, setting us up for muscle atrophy in old age.

23 Feb 2020

Muscle Wasting News and Research

UCLA researchers discover compound that stimulates muscle cells in mice

Serious ongoing symptoms in COVID-19 survivors

Study offers renewed hope for children suffering from myofibrillar myopathies

Neurobiologists decode central mechanism of degenerative processes in brains of mouse models

NIH awards grants for using bioengineered models to improve clinical trial design

Study uncovers a promising new therapeutic approach for Duchenne muscular dystrophy

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Ghrelin may help protect the elderly population from muscle loss

FDA approves first oral drug for treatment of spinal muscular atrophy

Buck researchers investigate ketone bodies as possible therapeutic against COVID-19

The Role of Nutrition in Recovery from COVID-19

Diluting blood plasma helps achieve age-reversing effects in mice

Activating specific brain cells can trigger hibernation-like state in mice

Scientists identify key cell signaling pathway that drives muscle loss

Researchers establish a gene expression profile associated with cachexia in cancer patients

Researchers discover glial cells that control stress response, extend lifespan in worms

Playing tennis could help prevent musculoskeletal conditions

A naturally occurring protein may be responsible for many benefits of exercise

Could high cholesterol lead to motor neuron disease?

Mitochondrial dysfunction may underlie prolonged muscle weakness after sepsis

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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