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Study finds top AI models still struggle with clinical reasoning

Researchers tested 21 frontier large language models on 29 stepwise MSD Manual clinical vignettes and found that, although many models performed well on final diagnosis, they remained much weaker at differential diagnosis and diagnostic testing. They also introduced the PrIME-LLM score, a multidimensional benchmark designed to better capture balanced clinical reasoning across the full workflow rather than raw accuracy alone.

14 Apr 2026

Microplastics found in human bile may be associated with gallstones

Findings show microplastics in bile may trigger cellular senescence, suggesting a link to gallstone disease and highlighting the need for further research.

9 Apr 2026

Dual perspective AI model achieves high accuracy in early lung cancer diagnosis

Lung cancer remains the leading cause of cancer-related deaths worldwide, accounting for nearly one in five cancer deaths - around 1.8 million lives lost each year.

7 Apr 2026

Could vitamin D in midlife protect your brain from early Alzheimer’s?

Higher serum vitamin D in midlife is associated with reduced tau burden in the brain, highlighting its potential role in early dementia risk assessment.

7 Apr 2026

AI-powered portable eye scanner makes vision screenings more accessible

Imagine being able to assess how healthy the front of our eyes are not only in hospitals, but also in remote eye-screening camps, elderly-care facilities, pharmacies, or even train stations.

2 Apr 2026

Highly potent opioid shows potential as therapy for pain and opioid use disorder

Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential as a therapy for both pain and opioid use disorder.

1 Apr 2026

Lung cancer scans can reveal signs of other undiagnosed cancers

When doctors review diagnostic medical scans for lung cancer, they sometimes spot abnormalities unrelated to the lungs.

31 Mar 2026

Uncovering the hidden retinal risks of modern dentistry

Dentists are exposed to intense lighting for long hours, but its long-term impact on eye health is often overlooked. This study evaluates whether chronic exposure to dental lighting, especially blue and white LEDs, can damage the retina and disrupt its normal function. By combining human data with advanced imaging and animal models, the research uncovers hidden occupational risks and highlights the need for safer lighting practices to help protect dentists' vision.

31 Mar 2026

Dual imaging reveals hidden causes of heart attacks without blockages

When Ashley Perlow felt a sharp pain shoot across her chest and into both wrists, she didn't think it could be a heart attack. She was 36, a new mom, and otherwise healthy.

30 Mar 2026

Measuring heart fat with AI improves cardiovascular risk prediction

Mayo Clinic research identified a powerful new way to improve the prediction of a patient's long-term cardiovascular disease risk by enhancing a routinely performed imaging test with artificial intelligence (AI).

30 Mar 2026

Triglyceride-lowering drug olezarsen fails to reduce arterial plaque

Despite experiencing significant reductions in triglycerides, patients with triglycerides over 150 mg/dL and a high risk of atherosclerosis did not experience any significant change in the amount of non-calcified plaque in their coronary arteries after taking the triglyceride-lowering drug olezarsen, in a one-year sub-study presented at the American College of Cardiology's Annual Scientific Session.

30 Mar 2026

LDCT screening significantly reduces lung cancer mortality in non-smokers

New evidence from a Chinese cohort presented today at the European Lung Cancer Congress (ELCC) 2026 shows that onetime lowdose computed tomography (LDCT) screening can significantly reduce lung cancer mortality in a non-risk based population, including individuals with no smoking history.

27 Mar 2026

Healthy thymus gland linked to longer life and immune stability

The thymus is a small organ located in the upper chest that plays a central role in the immune system: it produces T cells - specialized immune cells that recognize and fight pathogens.

26 Mar 2026

AI-driven OCT imaging system enables precise wound healing assessment

No matter the size or severity, wounds on human skin are difficult to monitor while they heal. Biopsies disrupt the wound site and are too invasive for routine, repeated monitoring, and most medical imaging devices that could do the job are large, expensive and booked up with more pressing diagnostics.

23 Mar 2026

A healthier thymus predicts longer life and lower cancer and heart disease risk in adults

Imaging-based analysis of over 27,000 adults shows that better thymic health is strongly associated with lower all-cause mortality, reduced lung cancer risk, and improved cardiovascular outcomes. The findings suggest the thymus remains biologically relevant in adulthood, linking immune aging, inflammation, and chronic disease risk, although causality cannot be established.

19 Mar 2026

Menopause may raise women’s Alzheimer risk earlier than doctors once thought

This review argues that women’s higher Alzheimer disease risk may be shaped in part by midlife neuroendocrine aging, especially the menopause transition, rather than by longevity alone. It highlights early menopause, bilateral oophorectomy, vasomotor symptoms, and midlife cognitive changes as underinvestigated but potentially important risk markers, while calling for sex-specific, biomarker-driven prevention strategies.

18 Mar 2026

The social and legal costs of ignoring AI diagnostics

Artificial intelligence (AI) is changing the field and practice of medicine, including legal liability and the perception of who is at fault when a patient experiences harm.

11 Mar 2026

New consensus defines oligometastatic stage in pancreatic cancer

Until now, the following has been true for metastatic pancreatic cancer: Once the tumor has spread, local treatment such as surgery is usually no longer an option.

10 Mar 2026

PET imaging reveals molecular mechanism behind ketamine's antidepressant effects

Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and approximately 30% of patients develop treatment-resistant depression (TRD), a condition that does not respond adequately to conventional antidepressant therapies.

6 Mar 2026

Researchers develop versatile machine learning tool to automate complex clinical diagnostics

A research team funded by the National Institutes of Health (NIH) has developed a versatile machine learning model that could one day greatly expand what medical scans can tell us about disease.

4 Mar 2026