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Trudeau Institute study holds promise for improved prevention and treatment of bacterial infections

New research from the laboratory of Dr. Andrea Cooper at the Trudeau Institute, just published in the European Journal of Immunology, holds promise for the improved prevention and treatment of bacterial infections and the life-threatening complications of chronic inflammation that can result from them.

29 Aug 2012

HIV-like immunodeficiency observed in Asia

Researchers have discovered an adult-onset immunodeficiency syndrome with symptoms similar to those of advanced HIV in Thailand and Taiwan.

24 Aug 2012

Specialist referral unearths wide spectrum of adult primary immune deficiencies

The range of adult primary immune deficiencies is considerable and the majority of patients are diagnosed only after specialist referral, conclude Canadian scientists who identified two novel patient groups with humoral abnormalities.

20 Aug 2012

Nurse-led HIV care benefits patients

Expansion of the role of primary care nurses to allow them to initiate and represcribe antiretroviral therapy to HIV patients improves health outcomes and quality of patient care, write researchers in The Lancet.

15 Aug 2012

CD4 T cells orchestrate inflammatory attack on the artery wall

Most people probably know that heart disease remains the nation's No. 1 killer. But what many may be surprised to learn is that cholesterol has a major accomplice in causing dangerous arterial plaque buildup that can trigger a heart attack. The culprit? Inflammatory cells produced by the immune system.

15 Aug 2012

Vorinostat drives HIV from hiding

The addition of vorinostat to current antiretroviral therapy regimens can potentially help to eradicate hidden pockets of dormant human immunodeficiency virus, according to study results published in Nature.

6 Aug 2012

HIV people with high CD4 counts could work more hours per week

In a first-of-its-kind health campaign in Uganda, researchers from the University of North Carolina at Chapel Hill show that adults with HIV who had less severe infections could work more hours per week, and their children were more likely to be enrolled in school.

1 Aug 2012

HPV co-testing prospect for HIV-infected women

The risk for cervical precancer and cancer is similar in HIV-infected and HIV-uninfected women with normal cervical cytology and no evidence of oncogenic human papillomavirus infection, research shows.

30 Jul 2012

Hydroxychloroquine fails to modify HIV in patients not taking ART

The use of hydroxychloroquine does not reduce CD8 cell activation in HIV-infected patients not taking antiretroviral therapy, research shows.

30 Jul 2012

Some AIDS experts view health law coverage expansion with hope

Meanwhile, the Obama administration announced it would add new funds to increase access to HIV/AIDS care, but questions remain about whether it will be enough to address waiting lists for the drug assistance program. Also in the news, reports on treatment developments.

30 Jul 2012

Early ART treatment delays AIDS-related health events in HIV-infected individuals

Further analyses of the landmark NIH-funded treatment-as-prevention study (HPTN 052) have found that providing antiretroviral treatment to HIV-infected individuals earlier, when their immune systems are healthier, delays AIDS-related health events, such as chronic herpes simplex virus and tuberculosis, as well as death. Additionally, researchers found that earlier HIV treatment is also cost-effective because it increases survival, prevents costly opportunistic infections and averts transmission of the virus to uninfected individuals.

30 Jul 2012

OX40 molecule responsible for airway inflammation in the lungs

A research team led by Xian Chang Li, MD, PhD, Brigham and Women's Hospital (BWH) Transplantation Research Center, has shed light on how a population of lymphocytes, called CD4+ T cells, mature into various subsets of adult T helper cells.

30 Jul 2012

Research presented at AIDS 2012 conference renews hope of cure for AIDS

Two studies presented at the XIX International AIDS Conference (AIDS 2012) and one published Wednesday in the British journal Nature "have given researchers renewed hope that a cure for AIDS may be possible," the Washington Post reports.

28 Jul 2012

Lymphoma drug dislodges hidden virus in HIV patients

Researchers from the University of North Carolina at Chapel Hill have published pioneering research showing that a drug used to treat certain types of lymphoma was able to dislodge hidden virus in patients receiving treatment for HIV.

27 Jul 2012

HIV drug resistance: an interview with Dr. Silvia Bertagnolio

Sexual intercourse is the major mode of HIV transmission. HIV may also be transmitted through sharing of needles or contaminated blood products (although this is rare).

27 Jul 2012

UNITAID to invest more than $140M to evaluate point-of-care HIV diagnostics, monitoring in Africa

International medicines financing mechanism UNITAID said on Monday it "will invest more than $140 million to evaluate point-of-care [PoC] HIV diagnostic and monitoring technology in seven African countries," PlusNews reports.

26 Jul 2012

Favorable results from BioCryst’s ulodesine plus allopurinol Phase 2b trial on gout

BioCryst Pharmaceuticals, Inc. announced favorable 52-week safety results and sustained efficacy from the extension phase of its randomized Phase 2b trial of ulodesine (BCX4208) added to allopurinol in patients with gout who had failed to reach the serum uric acid (sUA) therapeutic goal of <6 mg/dL on allopurinol alone, as well as positive Phase 2 safety results in patients with mild to moderate renal impairment.

25 Jul 2012

First results from community HIV testing campaign in Uganda

A clinical study in a remote region of southwest Uganda has demonstrated the feasibility of using a health campaign to rapidly test a community for HIV and simultaneously offer prevention and diagnosis for a variety of other diseases in rural and resource-poor settings of sub-Saharan Africa.

24 Jul 2012

All adult patients with HIV should be offered ART: International Antiviral Society-USA panel

Included in the 2012 International Antiviral Society-USA panel recommendations for human immunodeficiency virus (HIV) patient care is that all adult patients, regardless of CD4 cell count, should be offered antiretroviral therapy (ART), according to an article in the July 25 issue of JAMA, a theme issue on HIV/AIDS.

23 Jul 2012

Study addresses African patients’ attitudes toward HIV antiretroviral therapy

An ongoing clinical study in rural Uganda, begun in 2011, suggests that many people infected with HIV/AIDS would take antiretroviral drugs if they were available to them—even before they developed symptoms from the disease.

23 Jul 2012