Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Study hints why some melanomas more likely to spread

Usually starting as a blemish, skin cancer can quickly develop and spread to other parts of the body. The deadliest form of skin cancer, melanoma proliferates rapidly through the lymph nodes, affecting important internal organs. The disease can be variable, wherein some cancer cells never metastasize to the blood and lymph nodes and throughout the body, while others, tend to metastasize.

19 Dec 2019

Scientists create new classification system for tumors

Based on the largest study of cancer patients of its kind, scientists have created a new way of classifying tumors.

19 Dec 2019

Clinical study demonstrates effective alternative to mastectomy for recurrent breast cancer

Mastectomy has historically been the standard treatment for breast cancer patients experiencing recurrence after an initial lumpectomy and whole-breast radiation. Now, a phase 2 clinical trial led by Douglas W. Arthur, M.D., chair and professor in the Department of Radiation Oncology at VCU Massey Cancer Center and VCU School of Medicine, has demonstrated an effective alternative.

18 Dec 2019

Researchers identify molecular machinery that drives rapid polymerization of actin filaments

Many cells in our body constantly change their shape and move within our tissues. For example, wound healing and the immune system depend on migrating cells.

17 Dec 2019

CSHLP releases new book on 'Metastasis: Mechanism to Therapy'

Cold Spring Harbor Laboratory Press announced the release of Metastasis: Mechanism to Therapy, available on its website in Hardcover format.

14 Dec 2019

Molecular subtyping of bladder tumors outperformed by standard pathology tests

While trying to develop a comparatively easy, inexpensive way to give physicians and their patients with bladder cancer a better idea of likely outcome and best treatment options, scientists found that sophisticated new subtyping techniques designed to do this provide no better information than long-standing pathology tests.

14 Dec 2019

Continuous RCB index is an accurate and reliable tool to assess breast cancer prognosis

Researchers from The University of Texas MD Anderson Cancer Center today reported results from a pooled analysis of more than 5,100 breast cancer patients that found residual cancer burden continuous index and classification were independently and strongly prognostic for all breast cancer phenotypes.

13 Dec 2019

Discovery of novel mechanism by which certain breast cancers can metastasize

Researchers from the Baylor College of Medicine and Harvard Medical School have found a novel mechanism to explain the resistance of certain breast cancers that spread in the major organs of the body. They hope that this would help develop new therapeutic strategies to treat the cancer.

12 Dec 2019

New drug combo promises help for triple negative breast cancer patients

A new preclinical study on triple negative breast cancer (TNBC) reports that an experimental polo-like kinase 1 (PLK1) inhibitor shrank tumor four times more powerfully when used along with standard drugs than alone. The study, reported in the journal PLOS ONE, opens up a new door of opportunity for patients with this disease.

11 Dec 2019

Study sheds light on the factors at play in neuroblastoma metastasis

Neuroblastoma can grow and spread in the body very aggressively, making it very difficult to treat. New research has shed important light on the factors at play in the metastasis of neuroblastoma, which could potentially lead to new treatment strategies.

11 Dec 2019

Treatment combination improves survival in advanced HER2-positive breast cancer patients

Researchers from The University of Texas MD Anderson Cancer Center today reported study results showing the addition of tucatinib to capecitabine (Xeloda) and trastuzumab (Herceptin) significantly improved progression-free survival (PFS) and overall survival (OS) in patients with advanced HER2-positive breast cancer, with and without brain metastasis according to results of the HER2CLIMB clinical trial.

11 Dec 2019

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone.

10 Dec 2019

Researchers draw an evolutionary link between pregnancy and cancer malignancy

A UConn School of Dental Medicine researcher used pregnancy to unlock a missing link between various species of mammals and cancer malignancy--fundamentally changing the way we look at cancer metastasis.

5 Dec 2019

Tel Aviv Professor receives Young Investigator Award for contributions in melanoma research

Tel Aviv University's Prof. Carmit Levy received the prestigious Young Investigator Award at the 16th International Congress of the Society for Melanoma Research, held November 20-23 in Salt Lake City, Utah, for her "contributions to melanoma research that significantly exceeded the average for this career stage."

5 Dec 2019

New model can help study the mechanisms of bone metastasis, tumor immune response

The Research Team reports the establishment of B6Ca P, an allograft tumor line from a Hi-Myc transgenic mouse that had been backcrossed onto C57BL/6J background.

4 Dec 2019

Study identifies improved treatment option for neuroblastoma

Neuroblastoma is a rare form of malignant tumor, primarily affecting children under the age of six. A research team led by molecular pathologist Lukas Kenner from MedUni Vienna's Department of Pathology has now discovered, through genome sequencing, that the protein ALK and the cancer gene PIM1 are involved in the development of this tumor.

4 Dec 2019

Study suggests two new approaches against bone metastases from prostate cancer

When prostate cancer spreads, it most often spreads to bone. And while the 5-year survival rate for prostate cancer that has not spread is nearly 100 percent, once the disease reaches bone, the 5-year survival rate is only 29 percent.

2 Dec 2019

CD44 protein helps identify mother cells responsible for aggressive nature of neuroblastoma

A group of researchers from the University of Seville and the Seville Biomedicine Institute (Instituto de Biomedicina de Sevilla - IBiS) has published a study in which they determine that a protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old.

27 Nov 2019

Researchers reveal ineffectiveness of some treatments in tackling early-stage lung cancer

Researchers from Tohoku University and Tohoku University Hospital have revealed why some existing cancer treatments are ineffective in tackling the early-stages of lung cancer. A team led by Professor Tetsuya Kodama investigated the ability of anti-cancer agents to affect early-stage lung metastatic tumors.

27 Nov 2019

Study reveals novel pathway to target colorectal cancer

While the emergence of precision medicine and immunotherapy has greatly improved outcomes for patients with colorectal cancer, new approaches are still needed for patients with late-stage disease who do not respond to these therapies.

26 Nov 2019

Metastasis News and Research

Further Reading

Study hints why some melanomas more likely to spread

Scientists create new classification system for tumors

Clinical study demonstrates effective alternative to mastectomy for recurrent breast cancer

Researchers identify molecular machinery that drives rapid polymerization of actin filaments

CSHLP releases new book on 'Metastasis: Mechanism to Therapy'

Molecular subtyping of bladder tumors outperformed by standard pathology tests

Continuous RCB index is an accurate and reliable tool to assess breast cancer prognosis

Discovery of novel mechanism by which certain breast cancers can metastasize

New drug combo promises help for triple negative breast cancer patients

Study sheds light on the factors at play in neuroblastoma metastasis

Treatment combination improves survival in advanced HER2-positive breast cancer patients

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Researchers draw an evolutionary link between pregnancy and cancer malignancy

Tel Aviv Professor receives Young Investigator Award for contributions in melanoma research

New model can help study the mechanisms of bone metastasis, tumor immune response

Study identifies improved treatment option for neuroblastoma

Study suggests two new approaches against bone metastases from prostate cancer

CD44 protein helps identify mother cells responsible for aggressive nature of neuroblastoma

Researchers reveal ineffectiveness of some treatments in tackling early-stage lung cancer

Study reveals novel pathway to target colorectal cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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