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Intranasal vaccine shows promise against COVID variants in hamsters

Intranasal mRNA-LNP vaccines show promise in Syrian golden hamsters, effectively reducing SARS-CoV-2 viral loads and lung pathology. The study suggests potential efficacy against new variants, setting the stage for future research in human applications.

25 Sep 2023

Researchers identify key regulators involved in genesis of multiple sclerosis lesions

By means of CRISPR screening, LMU researchers have provided the first ever comprehensive molecular characterization of T cell infiltration into the central nervous system of people with MS.

22 Sep 2023

Study provides insights into human 8-cell-like cells and early embryonic development

The onset of embryo-specific gene transcription, also known as embryonic genome activation (EGA), is a crucial step in the developmental journey of an organism.

22 Sep 2023

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Researchers proposed a simplified approach for analyzing mRNA vaccines using long-read sequencing.

22 Sep 2023

Hokkaido red wines show promise in boosting vascular function

Researchers find that consuming red wines made from Zweigelt grape varietals cultivated in Hokkaido, Japan, can positively affect vascular and platelet function in healthy adult men, with the 2018 vintage having a more pronounced effect on blood pressure. The study highlights the role of specific polyphenolic profiles in wines for cardiovascular benefits.

21 Sep 2023

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

A comprehensive review in Signal Transduction and Targeted Therapy delves into the versatility and effectiveness of mRNA vaccines, from their game-changing role in COVID-19 to potential applications in cancer and rare diseases. Despite drawbacks like stability and high immunogenicity, advancements in vaccine technology have poised mRNA platforms as a robust tool for both preventive and therapeutic interventions.

21 Sep 2023

Brazilian fruits positively impact gut health and chronic disease prevention

The influence of Brazilian native fruits and their by-products on human intestinal microbiota.

21 Sep 2023

Creating CAR-T cells with enhanced immune memory to fight cancer

Among available immunotherapies, the use of «CAR-T» cells is proving extremely effective against certain blood cancers, but only in half of patients.

20 Sep 2023

New near-infrared activated photo-oxidants kill cancer cells without oxygen

A research team led by scientists from City University of Hong Kong (CityU) has achieved a significant breakthrough by inventing a new class of near-infrared-activated photo-oxidants that can effectively kill cancer cells without requiring oxygen.

20 Sep 2023

Is sucralose the safer sweetener for your gut health?

The study found that consuming a beverage sweetened with sucrose significantly increased bacterial endotoxin levels in the blood, a marker for inflammation and gut barrier dysfunction, while no such effect was observed with sucralose-sweetened drinks. The findings suggest that sucralose may be a safer alternative to sucrose in terms of intestinal health and inflammation.

19 Sep 2023

Transforming postpartum depression treatment with neurosteroids

A new study in Neuropsychopharmacology delves into the mechanisms of action of brexanolone, the first FDA-approved, rapid-acting antidepressant specifically for postpartum depression (PPD). The research highlights brexanolone's potential anti-inflammatory effects and its impact on GABAA receptors, offering insights into its efficacy and suggesting avenues for further study.

19 Sep 2023

New research offers insight about the reason mitochondrial DNA is maternally inherited

New research provides insight about the bedrock scientific principle that mitochondrial DNA - the distinct genetic code embedded in the organelle that serves as the powerplant of every cell in the body - is exclusively passed down by the mother.

19 Sep 2023

Bacteriophage cocktail can effectively disrupt Klebsiella pneumoniae biofilms on medical equipment

Researchers investigated whether a cocktail of bacteriophages coding for the depolymerase polysaccharide could effectively disrupt Klebsiella pneumoniae biofilms.

18 Sep 2023

Wireless molecular-electrical communications for tumor-cell-induced apoptosis

Researchers utilize electricity generated by wireless-induced redox interactions at bio-nanoantennae to cause apoptosis in cancerous cells.

18 Sep 2023

Purr-fectly plant-powered: study hints at healthier outcomes for cats on vegan diets

The effect of a meat-based or vegan diet on feline health.

18 Sep 2023

Unlocking the power of lectins: BOA emerges as a potent weapon against all SARS-CoV-2 variants

Researchers discover that antiviral lectins like BOA can effectively inhibit SARS-CoV-2 and its variants by targeting spike glycans, opening doors for potential pan-coronavirus treatments. The study reveals that BOA's multivalent interactions make it a potent inhibitor against a range of viral variants, offering promise for future therapeutic strategies.

14 Sep 2023

Research suggests laminin could play role in slowing progression of breast tumors

Cells are capable of translating mechanical changes into biological responses. This process is known as mechanotransduction and plays a fundamental role in the progression of solid tumors, such as breast cancer.

14 Sep 2023

MRI innovation to unveil iron homeostasis in the human brain

Researchers demonstrated a MRI method sensitive to the live brain's iron homeostasis (the r1-r2 extent of relaxation or relaxivity).

14 Sep 2023

Unhealthy pathobiome in the brain could cause some forms of Alzheimer's and related dementias

The human microbiome includes the genetic material of more than 100 trillion tiny microorganisms – fungi, yeast, bacteria, and even viruses, most of which hang out in our gastrointestinal tract to serve as guardians of our health.

13 Sep 2023

Innovative technique provides unparalleled insight into autism pathology

Does the human brain have an Achilles heel that ultimately leads to Autism? With a revolutionizing novel system that combines brain organoid technology and intricate genetics, researchers can now comprehensively test the effect of multiple mutations in parallel and at a single-cell level within human brain organoids.

13 Sep 2023

in vitro News and Research

Intranasal vaccine shows promise against COVID variants in hamsters

Researchers identify key regulators involved in genesis of multiple sclerosis lesions

Study provides insights into human 8-cell-like cells and early embryonic development

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Hokkaido red wines show promise in boosting vascular function

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

Brazilian fruits positively impact gut health and chronic disease prevention

Creating CAR-T cells with enhanced immune memory to fight cancer

New near-infrared activated photo-oxidants kill cancer cells without oxygen

Is sucralose the safer sweetener for your gut health?

Transforming postpartum depression treatment with neurosteroids

New research offers insight about the reason mitochondrial DNA is maternally inherited

Bacteriophage cocktail can effectively disrupt Klebsiella pneumoniae biofilms on medical equipment

Wireless molecular-electrical communications for tumor-cell-induced apoptosis

Purr-fectly plant-powered: study hints at healthier outcomes for cats on vegan diets

Unlocking the power of lectins: BOA emerges as a potent weapon against all SARS-CoV-2 variants

Research suggests laminin could play role in slowing progression of breast tumors

MRI innovation to unveil iron homeostasis in the human brain

Unhealthy pathobiome in the brain could cause some forms of Alzheimer's and related dementias

Innovative technique provides unparalleled insight into autism pathology

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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