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Use of thiazolidinediones by seniors linked with increased risk of heart problems

Older patients treated with the diabetes medications known as thiazolidinediones (which include rosiglitazone) had a significantly increased risk of heart attack, congestive heart failure and death, compared with the use of other hypoglycemic drugs, according to a study in the December 12 issue of JAMA.

13 Dec 2007

Study finds Avandia may increase risk of heart failure

A popular class of drugs for treating type 2 diabetes is under scrutiny again. A new Canadian study released by the Institute for Clinical Evaluative Sciences (ICES) finds that drugs such as Avandia increase the risk of heart failure, heart attacks and death.

13 Dec 2007

Researchers advance stem cell gene therapy

Ireland Cancer Center of University Hospitals Case Medical Center researchers have recently made great strides in stem cell gene therapy research by transferring a new gene to cancer patients, via their own stem cells, with the ultimate goal of being able to use stronger chemotherapy treatment with less severe side effects.

13 Dec 2007

GlaxoSmithKline response to JAMA article on ICES retrospective analysis

The following is GlaxoSmithKline's response to the retrospective analysis by the Institute for Clinical Evaluative Sciences (ICES) titled "Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes".

13 Dec 2007

Data confirm Dasatinib's effectiveness in resistant chronic myelogenous leukemia

Updated clinical trial results show that the drug dasatinib (Sprycel) continues to be highly effective in patients with chronic myelogenous leukemia who were unable to tolerate Gleevec or who developed resistance to it, reports a team led by researchers at Dana-Farber Cancer Institute.

12 Dec 2007

Cancer cell line developed that is resistant to new cancer therapy

A cancer cell line that is resistant to one of the newest classes of cancer treatments has been developed by researchers who already are using it to determine what else to give patients when this happens.

12 Dec 2007

Mouthguards harbor large numbers of bacteria - can lead to disease

Fractured teeth, neck injuries and abrasions in the mouth, also known as sports-related dental injuries, are ever present among athletes.

10 Dec 2007

Resverlogix receives FDA approval to start clinical trial for RVX-208

Resverlogix Corp. has announced that it has received approval by the US Food and Drug Administration (FDA) to initiate a Phase 1a clinical trial of oral RVX-208 in the USA. RVX-208 is a novel first-in-class small molecule that increases the production of ApoA-I and HDL.

10 Dec 2007

Doctors trained on patient simulators exhibit superior skills

Senior internal medicine residents who are trained in critical resuscitation skills on patient simulators become more skilled than residents who undergo traditional training, according to new research.

10 Dec 2007

Combination therapy including antibiotics may be beneficial for multiple sclerosis

A preliminary study suggests that combining a medication currently used to treat multiple sclerosis with an antibiotic may slow the progress of the disease, according to an article posted online today that will appear in the February 2008 print issue of Archives of Neurology.

10 Dec 2007

Study results from Zolinza (vorinostat) in combination with bortezomib for multiple myeloma trial

Results from two investigational Phase I trials of ZOLINZA (vorinostat) in combination with bortezomib provide preliminary anti-tumor activity in patients with relapsed and/or refractory multiple myeloma.

10 Dec 2007

Premature ejaculation drug Dapoxetine submitted for marketing in approval in Europe

Janssen-Cilag companies in Europe have submitted a Marketing Authorisation Application (MAA) for dapoxetine, a treatment for premature ejaculation (PE) in men 18-64 years of age.

10 Dec 2007

Multiple myeloma clinical trial shows distinct survival benefit with lower dose of steroids

Results of Eastern Cooperative Oncology Group Phase III clinical trial E4A03, for multiple myeloma, showing significantly better overall survival with lenalidomide plus low-dose dexamethasone therapy compared to lenalidomide plus high-dose dexamethasone, were reported today by S. Vincent Rajkumar, M.D. at the American Society of Hematology's annual meeting.

10 Dec 2007

Many cancers caused by infections

Cancer -- popularly understood as a result of mutations or mistakes within the genetic code in cells -- is also caused by infections from viruses, bacteria and parasites.

5 Dec 2007

Asacol treats UC symptoms of isolated proctitis

Data from two Phase III clinical trials support that Asacol, an oral, non-steroidal medication that belongs to the class of agents known as 5-aminosalicylic acids (5-ASAs), is an effective and well-tolerated treatment for patients with all extents of ulcerative colitis (UC), including isolated proctitis.

5 Dec 2007

Immtech and BioAlliance sign agreement on Pafuramidine for African sleeping sickness

Immtech Pharmaceuticals has announced that the Company has granted an exclusive license to BioAlliance Pharma SA to commercialize Immtech's oral drug, pafuramidine maleate (pafuramidine), in Europe for the treatment of pneumocystis pneumonia (PCP) in AIDS patients and for the treatment of Human African trypanosomiasis, also known as African sleeping sickness.

5 Dec 2007

Positive results from trial of investigational anti-epilepsy drug Brivaracetam

UCB has announced data demonstrating that anti-epileptic drug (AED) brivaracetam, with the proposed trade name Rikelta, administered as an adjunctive treatment in adults with refractory epilepsy with partial onset seizures, significantly reduced seizure frequency and had a side-effect profile comparable to placebo.

4 Dec 2007

Treating throat cancer with IMRT can improve quality of life compared to conventional radiation therapy

Treating throat cancer with intensity modulated radiation therapy (IMRT) can improve the health-related quality of life of patients compared to conventional radiation therapy (CRT), according to a study in the December 1 issue of the International Journal for Radiation Oncology*Biology*Physics, the official journal of the American Society for Therapeutic Radiology and Oncology.

3 Dec 2007

Bionovo describes a new class of therapeutic compounds

Bionovo, Inc. has announced the publication of a groundbreaking paper in the journal Molecular and Cellular Endocrinology covering the isolation, identification and description of a pure chemical compound, liquiritigenin, which represents a new class of therapeutic compounds showing promise for the safe treatment of menopausal symptoms.

2 Dec 2007

Eltrombopag studied in Idiopathic Thrombocytopenic Purpura

There are estimated to be between 50,000 -- 100,000 individuals in the U.S. diagnosed with chronic Immune Thrombocytopenic Purpura (ITP), an autoimmune disease that dramatically reduces the number of platelets in their blood -- causing bruises, nosebleeds and, sometimes, life-threatening brain hemorrhages.

29 Nov 2007

Oral News and Research

Use of thiazolidinediones by seniors linked with increased risk of heart problems

Study finds Avandia may increase risk of heart failure

Researchers advance stem cell gene therapy

GlaxoSmithKline response to JAMA article on ICES retrospective analysis

Data confirm Dasatinib's effectiveness in resistant chronic myelogenous leukemia

Cancer cell line developed that is resistant to new cancer therapy

Mouthguards harbor large numbers of bacteria - can lead to disease

Resverlogix receives FDA approval to start clinical trial for RVX-208

Doctors trained on patient simulators exhibit superior skills

Combination therapy including antibiotics may be beneficial for multiple sclerosis

Study results from Zolinza (vorinostat) in combination with bortezomib for multiple myeloma trial

Premature ejaculation drug Dapoxetine submitted for marketing in approval in Europe

Multiple myeloma clinical trial shows distinct survival benefit with lower dose of steroids

Many cancers caused by infections

Asacol treats UC symptoms of isolated proctitis

Immtech and BioAlliance sign agreement on Pafuramidine for African sleeping sickness

Positive results from trial of investigational anti-epilepsy drug Brivaracetam

Treating throat cancer with IMRT can improve quality of life compared to conventional radiation therapy

Bionovo describes a new class of therapeutic compounds

Eltrombopag studied in Idiopathic Thrombocytopenic Purpura

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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