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GlobalData: COVID-19 has pushed infectious disease drugs to top therapy area for CSAs

Infectious disease drugs have overtaken oncology as the year’s top therapy area for contract service agreements as companies are shifting their current focus to developing treatments to battle the COVID-19 pandemic.

25 Jul 2020

New study helps identify patients at higher risk of statin-related myopathy

Statins are prescribed to millions of people worldwide to reduce their risks of suffering heart attacks and strokes.

25 Jul 2020

Seaweed extract outperforms remdesivir in inhibiting SARS-CoV-2 in cell studies

In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease.

24 Jul 2020

Exercise equipment in communal gyms have high levels of antibiotic-resistant bacteria

Research presented at ASM Microbe Online found that 43% of Staphylococcus bacteria found on exercise equipment in university gyms were ampicillin-resistant, with 73% of those isolates being resistant to multiple additional drugs.

24 Jul 2020

Researchers discover new method to treat herpes viruses

Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted.

24 Jul 2020

Neurotransmitter-derived lipidoids help carry drugs across the blood-brain barrier in mice

Biomedical engineers at the Tufts University School of Engineering have developed tiny lipid-based nanoparticles that incorporate neurotranmitters to help carry drugs, large molecules, and even gene editing proteins across the blood-brain barrier and into the brain in mice.

24 Jul 2020

UB study validates a novel pharmacological target for Alzheimer’s disease

A UB study published in the journal Neurotherapeutics has validated a new pharmacological target for Alzheimer's disease.

24 Jul 2020

Scientists discover how coronavirus enters cells without encountering immune system resistance

With an alarm code, we can enter a building without bells going off. It turns out that the SARS coronavirus 2 (SARS-CoV-2) has the same advantage entering cells. It possesses the code to waltz right in.

24 Jul 2020

Study shows inert drug ingredients could lead to unanticipated side effects

Some supposedly inert ingredients in common drugs -- such as dyes and preservatives -- may potentially be biologically active and could lead to unanticipated side effects, according to a preliminary new study by researchers from the UC San Francisco School of Pharmacy and the Novartis Institutes for BioMedical Research (NIBR).

24 Jul 2020

Hypertension drugs are associated with elevated incidence of heart failure

L-type calcium channel blockers (LCCBs) -- the most widely used drugs for treating hypertension -- may harm the heart as much as help it, according to a new study.

24 Jul 2020

New model may explain why certain cancer cells are resistant to therapy

Cancer's knack for developing resistance to chemotherapy has long been a major obstacle to achieving lasting remissions or cures.

24 Jul 2020

Novel research determines the prevalence of chronic kidney disease

A new study looking at nearly three decades of data from some 54,000 people has determined that the overall prevalence of chronic kidney disease (CKD) for several racial/ethnic and socioeconomic groups in the United States has stabilized in recent years, except Mexican Americans.

24 Jul 2020

Modulating immunometabolic processes to control lung infection

When drugs to kill microbes are ineffective, host-directed therapy uses the body's own immune system to deal with the infection.

23 Jul 2020

Epigenomic modifications play key role in the development of lung tumors

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

23 Jul 2020

Mouse orthotopic model was used to determine personalized therapy for relapse sarcoma

A team from IDIBELL and ICO, using a mouse orthotopic model, conducted a real-time personalized oncology study to test the best therapeutic option to treat a type of relapse sarcoma. Malignant Peripheral Nerve Sheath Tumor are very aggressive and do not usually have a good prognosis, especially if complete surgical excision cannot be achieved.

23 Jul 2020

New technology could speed up drug discovery to fight tuberculosis

A new technology that combines high throughput imaging and machine learning could speed discovery of drugs to fight tuberculosis, which for generations has killed more people worldwide than any other disease caused by a single agent - 4,000 people every day.

23 Jul 2020

Study uncovers dual role for molecule involved in autoimmune eye disease

The inflammatory molecule interleukin-17A (IL-17A) triggers immune cells that in turn reduce IL-17A's pro-inflammatory activity, according to a study by National Eye Institute researchers.

23 Jul 2020

Study shows molecular mechanism of SARS-CoV-2 Mpro

The Computational Biochemistry Group's research has been selected as one of the most outstanding studies of 2020 by the journal Chemical Science.

23 Jul 2020

Non-invasive algorithm predicts complications in patients following recovery from hepatitis C

The chronic viral inflammation of the liver that occurs in hepatitis C results in the formation of inflexible scar tissue in the form of fibrosis/cirrhosis of the liver. This impedes the flow of blood through the organ, with resulting hypertension in the portal vein.

23 Jul 2020

Prednisone, Hydroxychloroquine best among COVID-19 treatments, claims large Spanish study

The COVID-19 pandemic has taken the lives of several hundred thousand people across the world. In Spain, a intense outbreak took a toll of over 28,000 lives.

23 Jul 2020