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Neuropathology of COVID-19 patients caused by infection of brain pericytes

Recently, researchers from the UK and Sweden used highly sensitive multiplexed immunohistochemistry to study the brain tissue of COVID-19 patients and controls to analyze ACE2 expression in brain pericytes of patients with neurological symptoms. They also used spatial immunophenotyping to assess inflammation in brain tissue of COVID-19 patients.

31 May 2021

A novel multi-epitope COVID-19 vaccine developed using reverse vaccinology

A new study has been published in the Journal of Biomolecular Structure and Dynamics which focuses on the evaluation of E, M, N, ORF10, ORF8, ORF3a, and M proteins using bioinformatics tools to develop a multi-epitope COVID-19 vaccine. The researchers utilized in-silico methods to incite humoral and cellular immune responses.

31 May 2021

Researchers identify defensins as potential anti-SARS-CoV-2 agents

A recent study conducted at the Ohio State University, USA, and the Fudan University, China, has revealed that alpha-defensin human neutrophil peptide 1 (HNP1), a cationic antimicrobial peptide, can prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from infecting cells by destabilizing the viral spike protein and disrupting spike-mediated viral envelop – host cell membrane fusion.

31 May 2021

B.1.617.2 variant of SARS-CoV-2 is partially resistant to antibody-mediated neutralization

A team of scientists from France has recently conducted a study to evaluate the sensitivity of the B.1.617 variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to antibody-mediated neutralization.

31 May 2021

Researcher from Hollings Cancer Center wins Melanoma Research Alliance grant

MUSC Hollings Cancer Center researcher Haizhen (Jen) Wang, Ph.D., recently was awarded a three-year $225,000 Young Investigator grant from the Melanoma Research Alliance.

29 May 2021

Synbal and La Jolla Institute for Immunology collaborate to develop better COVID-19 models

The La Jolla Institute for Immunology (LJI) is partnering with Synbal, Inc., a preclinical biotechnology company based in San Diego, CA, to develop multi-gene, humanized mouse models for COVID-19 research. The research at LJI will be led by Professor Sujan Shresta, Ph.D., a member of the Institute's Center for Infectious Disease and Vaccine Research.

29 May 2021

DFG establishes new collaborative research centers to promote world-class research at universities

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is establishing eleven new Collaborative Research Centers (CRC) to promote world-class research at universities. This was announced by the relevant Grants Committee, which met by video conference due to the coronavirus pandemic.

29 May 2021

Candy-like models could make science more accessible to visually impaired students

About 36 million people have blindness including 1 million children. Additionally, 216 million people experience moderate to severe visual impairment. However, STEM (science, technology, engineering and math) education maintains a reliance on three-dimensional imagery for education. Most of this imagery is inaccessible to students with blindness.

29 May 2021

Study shows that breast cancer can be prevented with better contraception choices

Hormonal contraceptives, e.g. the pill, the patch, and the vaginal ring, contain synthetic hormones that prevent pregnancy by either stopping ovulation, changing the cervical mucus to stop sperm from passing through the cervix and finding an egg, or changing the womb's lining to prevent a fertilized egg from being implanted in it.

29 May 2021

New light-sheet fluorescence microscope provides high spatial resolution, lowers phototoxicity

A research group led by Takashi Saito, of the Ehime University Graduate School of Medicine, developed a 2-photon excitation light-sheet fluorescence microscope which (1) lowers phototoxicity, (2) extends the field of view, and (3) heightens spatial resolution.

29 May 2021

Study sheds new light on human brain development

University of Virginia School of Medicine researchers have shed new light on how our brains develop, revealing that the very last step in cell division is crucial for the brain to reach its proper size and function.

29 May 2021

Mass screening reveals significantly higher numbers of coeliac disease cases in children

Mass screening of school age children has led to significantly higher numbers of coeliac disease cases being diagnosed, according to a new study presented today at the 6th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition.

29 May 2021

New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials

A new study, published in Nano Letters, describes an effective new COVID-19 vaccine candidate based on a messenger ribonucleic acid (mRNA) platform.

28 May 2021

Loss of gut epithelial barrier responsible for COVID-19-related MIS-C in children, suggests study

A new paper in the Journal of Clinical Investigation reports that this condition is due to damage to the gut, mediated by a decrease in the protein called zonulin, which is responsible for the integrity of the gut epithelial barrier. Reduced zonulin levels are found in several inflammatory and autoimmune conditions.

28 May 2021

Researchers identify a novel SARS-CoV-2 variant (with the V1230L mutation) in West Bengal, India

Researchers analyzed 2,000 viral genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of coronavirus disease 2019 (COVID-19) – sequences obtained from India and found a new variant that could be more infectious and transmissible.

28 May 2021

Glycosylation a significant element in SARS-CoV-2 infection and vaccine design, says study

A new study by researchers from Taiwan and the US suggests that the removal of unnecessary glycans from spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposes highly conserved sequences and opens the door for the development of broadly protective vaccines against the virus and its variants.

28 May 2021

Study supports single-dose COVID-19 vaccine strategy for previously infected individuals

Researchers in the Netherlands have provided evidence that a single dose of Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine is sufficient to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among people who have already been infected with the virus.

28 May 2021

Identifying SARS-CoV-2 epitopes targeted by current vaccination could help improve future vaccines

Researchers in the United States have identified antibody-inducing epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals vaccinated against coronavirus disease 2019 (COVID-19) that could be used for future diagnostics, therapeutics, and vaccine design.

28 May 2021

Will emerging SARS-CoV-2 variants affect T cell immunity? A meta-analysis

New research by a team of scientists at The Hong Kong University of Science and Technology sheds light on the epitopic targets of SARS-CoV-2 by T cells in COVID-19 convalescents. The team’s findings suggest that the epitopes targeted by T cells during infection may not be affected by the emergence of SARS-CoV-2 variants.

28 May 2021

IP6 molecules are key to stabilizing and protecting retroviruses

A newly discovered molecule central to the assembly of HIV may provide valuable insight into the development and function of viruses and how to combat them.

28 May 2021

Protein C News and Research

Neuropathology of COVID-19 patients caused by infection of brain pericytes

A novel multi-epitope COVID-19 vaccine developed using reverse vaccinology

Researchers identify defensins as potential anti-SARS-CoV-2 agents

B.1.617.2 variant of SARS-CoV-2 is partially resistant to antibody-mediated neutralization

Researcher from Hollings Cancer Center wins Melanoma Research Alliance grant

Synbal and La Jolla Institute for Immunology collaborate to develop better COVID-19 models

DFG establishes new collaborative research centers to promote world-class research at universities

Candy-like models could make science more accessible to visually impaired students

Study shows that breast cancer can be prevented with better contraception choices

New light-sheet fluorescence microscope provides high spatial resolution, lowers phototoxicity

Study sheds new light on human brain development

Mass screening reveals significantly higher numbers of coeliac disease cases in children

New LNP-based mRNA vaccine candidate protects against lethal SARS-CoV-2 in preclinical trials

Loss of gut epithelial barrier responsible for COVID-19-related MIS-C in children, suggests study

Researchers identify a novel SARS-CoV-2 variant (with the V1230L mutation) in West Bengal, India

Glycosylation a significant element in SARS-CoV-2 infection and vaccine design, says study

Study supports single-dose COVID-19 vaccine strategy for previously infected individuals

Identifying SARS-CoV-2 epitopes targeted by current vaccination could help improve future vaccines

Will emerging SARS-CoV-2 variants affect T cell immunity? A meta-analysis

IP6 molecules are key to stabilizing and protecting retroviruses

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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