Genes News and Research

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EPFL researchers uncover how the circadian clock regulates 3D chromatin structure

EPFL biologists and geneticists have uncovered how the circadian clock orchestrates the 24-hour cycle of gene expression by regulating the structure of chromatin, the tightly wound DNA-protein complex of the cell. The work is published in Genes & Development.

28 Mar 2018

FDA-approved inhibitors could be repurposed to target ARID1A-mutant ovarian cancers

Wistar researchers have found rationale for repurposing a class of antitumor compounds called HDAC inhibitors, already approved by the FDA for the treatment of diseases such as leukemia, as a new therapeutic option for ovarian cancer with mutations in the ARID1A gene.

27 Mar 2018

Johns Hopkins researchers make great strides in understanding biology behind pulmonary hypertension

Working with cells that line the innermost layer of the blood vessels, Johns Hopkins investigators say they have made a leap forward in understanding the underlying biology behind pulmonary hypertension, a dangerous type of high blood pressure in lungs that ultimately leads to right heart failure and death.

27 Mar 2018

Study links essential oils to hormonal imbalances

A new study has found that common chemicals found in essential oils may have adverse health impacts, contrary to popular belief.

27 Mar 2018

Combination therapy effectively induces tumor cell death and reduces spread of breast cancer

Each day, normal human cell tissues express a protein known as p53 that wages war against potential malignancies. However, between 30 and 40 percent of human breast cancers express a defective (mutant) form of p53 that helps cancer cells proliferate and grow.

27 Mar 2018

Study identifies genetic factors linked to severity of acute viral bronchiolitis

A scientific study conducted at the State University of Campinas (UNICAMP) in São Paulo State, Brazil, has identified genetic factors associated with the severity of acute viral bronchiolitis. The study was supported by the Sao Paulo Research Foundation - FAPESP. Its results were published in the journal Gene.

27 Mar 2018

Antibody sweeps away Alzheimer's plaques in mice

Years before people start showing characteristic symptoms of Alzheimer's disease, sticky plaques begin forming in their brains, damaging nearby cells. For decades, doctors have sought ways to clear out these plaques as a way to prevent or treat the disease.

27 Mar 2018

Researchers develop comprehensive map of genetic risk factors for stroke

Stroke is a serious disease affecting blood flow to and from the brain, and is the second leading cause of death worldwide. Stroke is characterized by a sudden onset of neurological dysfunction, caused by a blood clot or hemorrhage in a cerebral artery. While many genetic variants and lifestyle behaviors have been identified as risk factors for stroke, the genetic basis for the disease is unknown.

26 Mar 2018

Research provides better understanding of how some cancer cells resist treatment

An international team of researchers led by Lucio Miele, MD, PhD, Professor and Chair of Genetics at LSU Health New Orleans School of Medicine, and Justin Stebbing, BM BCh MA, PhD, Professor of Cancer Medicine and Medical Oncology at Imperial College of Medicine in London, has found new genetic mutations that promote the survival of cancer cells.

23 Mar 2018

Researchers probe RNA epigenetics and chromatin structures to predict drug resistance in leukemia

Drug resistance is a major obstacle to effective treatment for patients with cancer and leukemia. Epigenetic modifying drugs have been proven effective for some patients with hematologic malignancies, such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).

23 Mar 2018

Mutations found in bassoon gene may help explain cause of rare brain disorder

Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.

23 Mar 2018

New test for urothelial cancers offers less invasive, more accurate detection

A new test for urothelial cancers could detect mutations in DNA that have been identified for those cancers earlier than traditional tests. The earlier detection of urothelial cancer could lead to earlier treatment, and potentially better outcomes for patients.

23 Mar 2018

Mice getting a new lease of life with anti-aging pills

According to a new study from the researchers at Harvard Medical School and the University of New South Wales, the actually cellular processes that cause aging of the blood vessels have been understood.

23 Mar 2018

Maternal obesity and androgen excess induce sex-specific anxiety in offspring, study suggests

Maternal obesity and androgen excess induce sex-specific anxiety in the offspring, according to a study on mice by researchers at Karolinska Institutet in Sweden published in The FASEB Journal.

22 Mar 2018

Newly designed three-part molecule shows promise to treat breast cancers

A newly designed three-part molecule could be the one answer patients with a certain form of breast cancer are looking for, scientists report.

22 Mar 2018

Study reveals genes that cause extreme nausea and vomiting in pregnancy

Researchers have identified two genes that are associated with severe nausea and vomiting during pregnancy, a condition known of as hyperemesis gravidarum.

22 Mar 2018

Agendia receives CE mark for MammaPrint BluePrint Breast Cancer Recurrence and Molecular Subtyping Kit

Agendia, Inc., a world leader in personalized medicine and molecular cancer diagnostics, today announces that its next-generation sequencing-based MammaPrint BluePrint Breast Cancer Recurrence and Molecular Subtyping Kit is now CE marked, enabling the Company to commercialize the device in Europe.

22 Mar 2018

Study uncovers new genetic cause of posterior polymorphous corneal dystrophy

A new genetic cause of corneal dystrophy has been discovered with funding from Fight for Sight by researchers at UCL Institute of Ophthalmology and Moorfields Eye Hospital London, in collaboration with colleagues in the Czech Republic.

22 Mar 2018

Neuroscientists move closer to developing tools for deciphering brain function

A team of University of Missouri neuroscientists are inching closer to developing the tools needed to decipher the brain.

21 Mar 2018

Discovery of new ALS gene points to cytoskeleton as potential target for drug development

An international team of researchers led by John Landers, PhD, at UMass Medical School, and Bryan Traynor, MD, PhD, at the National Institute on Aging at the National Institutes of Health, has identified KIF5A as a new gene associated with the development of amyotrophic lateral sclerosis.

21 Mar 2018

Genes News and Research

EPFL researchers uncover how the circadian clock regulates 3D chromatin structure

FDA-approved inhibitors could be repurposed to target ARID1A-mutant ovarian cancers

Johns Hopkins researchers make great strides in understanding biology behind pulmonary hypertension

Study links essential oils to hormonal imbalances

Combination therapy effectively induces tumor cell death and reduces spread of breast cancer

Study identifies genetic factors linked to severity of acute viral bronchiolitis

Antibody sweeps away Alzheimer's plaques in mice

Researchers develop comprehensive map of genetic risk factors for stroke

Research provides better understanding of how some cancer cells resist treatment

Researchers probe RNA epigenetics and chromatin structures to predict drug resistance in leukemia

Mutations found in bassoon gene may help explain cause of rare brain disorder

New test for urothelial cancers offers less invasive, more accurate detection

Mice getting a new lease of life with anti-aging pills

Maternal obesity and androgen excess induce sex-specific anxiety in offspring, study suggests

Newly designed three-part molecule shows promise to treat breast cancers

Study reveals genes that cause extreme nausea and vomiting in pregnancy

Agendia receives CE mark for MammaPrint BluePrint Breast Cancer Recurrence and Molecular Subtyping Kit

Study uncovers new genetic cause of posterior polymorphous corneal dystrophy

Neuroscientists move closer to developing tools for deciphering brain function

Discovery of new ALS gene points to cytoskeleton as potential target for drug development

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