Animal Model News and Research

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Researchers test new vaccination strategy against HIV-related SIV in monkeys

According to the WHO, there are currently more than 36 million people infected with the human immunodeficiency virus (HIV) and a further 2.4 million become infected every year.

15 Nov 2017

Researchers use novel computational tool to understand complex disease processes

Hypertension and heart disease arise from many contributing and interacting factors: genetics, food, and exercise, as well as problems with heart, liver, or kidney function.

14 Nov 2017

UMD study provides important insights into early sensory development

Some expectant parents play classical music for their unborn babies, hoping to boost their children's cognitive capacity later in life.

7 Nov 2017

Study shows hemodynamic and metabolic changes up to 7 days after traumatic spinal cord injury

Researchers have shown that some of the critical pathophysiological responses to traumatic spinal cord injury (SCI), evidence of insufficient oxygen levels and metabolic stress that can permanently damage tissue, persist for at least a week post-injury at and extending away from the injury site in a large animal model.

6 Nov 2017

Researchers discover how traffic jam in intracellular sorting can cause tumor development

For tissues to cooperate and perform normal functions, cells need to know which way is up. When cells lose track of their orientation, they can start to grow out of control, and develop into cancer.

6 Nov 2017

Stem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process

Stem cell therapy has great potential for curing cartilage damage. However, it has remained unclear whether stem cells are responsible for regeneration or whether they trigger the process.

31 Oct 2017

Researchers isolate new molecule suitable for control of contact allergies

Researchers from the University of Bonn have isolated a molecule that is suitable for the control of contact allergies. The study illuminates a central immune mechanism, which may also play a role in other inflammatory diseases such as arthritis or arteriosclerosis.

30 Oct 2017

Novel molecule holds potential to become part of successful HIV vaccine

Researchers at the University of Maryland and Duke University have designed a novel protein-sugar vaccine candidate that, in an animal model, stimulated an immune response against sugars that form a protective shield around HIV. The molecule could one day become part of a successful HIV vaccine.

27 Oct 2017

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

In many metastasized types of cancer, disseminated tumors grow back despite successful chemotherapy. As a research team under the direction of the University of Bern, Switzerland, has now discovered, this is because of isolated cancer cells that survive the chemotherapy due to a phase of dormancy.

27 Oct 2017

Direct application of immune cells accelerates healing of acute, chronic wounds in mice

A Massachusetts General Hospital research team has found a surprising potential solution to a persistent clinical problem - the healing of chronic wounds. In their report published in Wound Repair and Regeneration, the investigators from the MGH Vaccine and Immunotherapy Center describe how application of mature B lymphocytes - the immune cells best known for producing antibodies - greatly accelerated the healing of acute and chronic wounds in both diabetic and nondiabetic mice.

25 Oct 2017

Key enzyme may be therapeutic target to treat diabetes-related blood vessel damage

A key enzyme that helps our proteins fold and function properly may also be a good therapeutic target to improve blood vessel health in diseases like diabetes and atherosclerosis, scientists say.

23 Oct 2017

New study explores how herpes simplex virus may change during familial transmission

A new study explores how herpes simplex virus might change when passed from one individual to another, information that may prove useful in future development of therapeutics and vaccines.

20 Oct 2017

Researchers use nanopore technique to detect biomarkers of disease

Adam Hall, Ph.D., isn't kidding when he says the research he does is on a very small scale. But he is understating things more than just a little.

20 Oct 2017

Umass Amherst scientist receives grant to study pollutant effects on embryos in animal models

Environmental health scientist Alicia Timme-Laragy at the University of Massachusetts Amherst recently received a $1.9 million grant from the National Institute of Environmental Health Sciences to study the health effects of two environmental pollutants, perfluoro-octanesulfonic acid (PFOS) and its recent replacement chemical, perfluoro-butanesulfonic (PFBS).

20 Oct 2017

Researchers reveal how certain nerves sustain prostate cancer growth

In a study in today's issue of Science, researchers at Albert Einstein College of Medicine, part of Montefiore Medicine, report that certain nerves sustain prostate cancer growth by triggering a switch that causes tumor vessels to proliferate.

20 Oct 2017

T1DM weakens autonomic reflex that regulates blood pressure during exercise, study finds

A new study finds that late-stage type 1 diabetes mellitus (T1DM) weakens the autonomic reflex that regulates blood pressure during exercise, impairing circulation, nerve function and exercise tolerance. The study is published in the American Journal of Physiology - Heart and Circulatory Physiology.

19 Oct 2017

Discovery may lead to new approach for treating MS

Around 2.5 million people are affected by the autoimmune disease Multiple Sclerosis (MS), the commonest central nervous system disease among young adults.

17 Oct 2017

Markey's cancer researcher wins NIH's New Innovator Award

University of Kentucky Markey Cancer Center Researcher Jessica Blackburn has earned a prestigious National Institutes of Health's New Innovator Award, a grant totaling $1.5 million over five years to fund pediatric cancer research.

6 Oct 2017

Study reveals link between dietary potassium and vascular calcification

A new study conducted at the University of Alabama at Birmingham suggested that potassium rich food like avocados and bananas might aid in protection against hardening of the arteries, also mentioned as pathogenic vascular calcification.

6 Oct 2017

NIH awards $2.3 million grant to Umass Amherst microbiologist for TB research

The National Institutes of Health announced today that microbiologist Sloan Siegrist at the University of Massachusetts Amherst has received a five-year, $2.3 million National Institutes of Health New Innovator Award, which supports "unusually innovative research from early career investigators," to study the bacterium that causes tuberculosis (TB).

5 Oct 2017

Animal Model News and Research

Researchers test new vaccination strategy against HIV-related SIV in monkeys

Researchers use novel computational tool to understand complex disease processes

UMD study provides important insights into early sensory development

Study shows hemodynamic and metabolic changes up to 7 days after traumatic spinal cord injury

Researchers discover how traffic jam in intracellular sorting can cause tumor development

Stem cells do not participate directly in cartilage regeneration but serve to ‘animate’ the process

Researchers isolate new molecule suitable for control of contact allergies

Novel molecule holds potential to become part of successful HIV vaccine

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

Direct application of immune cells accelerates healing of acute, chronic wounds in mice

Key enzyme may be therapeutic target to treat diabetes-related blood vessel damage

New study explores how herpes simplex virus may change during familial transmission

Researchers use nanopore technique to detect biomarkers of disease

Umass Amherst scientist receives grant to study pollutant effects on embryos in animal models

Researchers reveal how certain nerves sustain prostate cancer growth

T1DM weakens autonomic reflex that regulates blood pressure during exercise, study finds

Discovery may lead to new approach for treating MS

Markey's cancer researcher wins NIH's New Innovator Award

Study reveals link between dietary potassium and vascular calcification

NIH awards $2.3 million grant to Umass Amherst microbiologist for TB research

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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