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Dopamine improves deficiencies in social behavior, could have implications for neuropsychiatric disorders

A stressful pregnancy might be the last thing a future mother needs, but it is to her unborn baby that this stress spells real trouble. All because stress hormones (called glucocorticoids or GCs) can disturb normal foetal brain development, leading to behavioural and/or emotional problems later in life.

5 Sep 2013

TSRI scientists discover isoform of angiomotin protein responsible for tumorigenesis

A team led by scientists from The Scripps Research Institute (TSRI) have shown that a protein once thought to inhibit the growth of tumors is instead required for initial tumor growth. The findings could point to a new approach to cancer treatment.

5 Sep 2013

Research on long-lived proteins may lead to better understanding of molecular basis of aging

Proteins are the chief actors in cells, carrying out the duties specified by information encoded in our genes. Most proteins live only two days or less, ensuring that those damaged by inevitable chemical modifications are replaced with new functional copies.

4 Sep 2013

Researchers discover role played by epigenetic factors in senescence and age-related diseases

One way cells promote tumor suppression is through a process called senescence, an irreversible arrest of proliferation. Senescence is thought to be associated with normal aging, but is also a protective measure by the body against run-away cell replication.

31 Aug 2013

Researchers discover new gene mutations which cause devastating mitochondrial disorders

Researchers have identified a novel disease gene in which mutations cause rare but devastating genetic diseases known as mitochondrial disorders.

30 Aug 2013

Scientists discover crucial role of nitric oxide in cellular signaling and health

Scientists at the University of Illinois at Chicago College of Pharmacy have discovered a new role for nitric oxide, a gas molecule crucial for cellular signaling and health.

26 Aug 2013

Study: Mother's mitochondrial DNA seems to influence our own aging

As we age, our cells change and become damaged. Now, researchers at Karolinska Institutet and the Max Planck Institute for Biology of Aging have shown that aging is determined not only by the accumulation of changes during our lifetime but also by the genes we acquire from our mothers.

22 Aug 2013

Study: Herniated discs result from avulsion of tissue, rather than rupture

Herniated discs in the lower (lumbar) spine most often result from avulsion (separation) of the tissue connection between the disc and spinal bone, rather than rupture of the disc itself, according to a study in Spine. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

16 Aug 2013

Proton therapy provides organ-sparing treatment option for children with neuroblastoma

Proton therapy, using high-energy subatomic particles, may offer a precise, organ-sparing treatment option for children with high-risk forms of neuroblastoma. For patients in a new study of advanced radiation treatment, proton therapy spared the liver and kidneys from unwanted radiation, while zeroing in on its target.

14 Aug 2013

Specialized endocytocis play a crucial role in shaping cells themselves

The process cells use to 'swallow' up nutrients, hormones and other signals from their environment - called endocytosis - can play a crucial role in shaping the cells themselves, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found.

12 Aug 2013

High mobility group (HMG) genes and cancer: an interview with Dr. Linda Resar, Johns Hopkins University School of Medicine

High mobility group A genes are highly expressed in all aggressive cancers studied to date. These genes encode the high mobility group A (HMGA) proteins. In other words, these genes provide the genetic “code” necessary to produce HMGA proteins.

8 Aug 2013

Study opens door to possible treatments for variety of mitochondrial diseases

By borrowing a tool from bacteria that infect plants, scientists have developed a new approach to eliminate mutated DNA inside mitochondria-the energy factories within cells. Doctors might someday use the approach to treat a variety of mitochondrial diseases, including the degenerative eye disease Leber hereditary optic neuropathy. The research, published online today in Nature Medicine, was funded by the National Eye Institute, a part of the National Institutes of Health.

5 Aug 2013

New research may influence development of anti-viral therapies to fight against Dengue

New research into the fight against Dengue, an insect-borne tropical disease that infects up to 390 million people worldwide annually, may influence the development of anti-viral therapies that are effective against all four types of the virus.

3 Aug 2013

Researchers show that JQ1 drug can block molecular pathway responsible for heart failure

Researchers from Case Western Reserve University School of Medicine and the Dana-Farber Cancer Institute have made a fundamental discovery relevant to the understanding and treatment of heart failure - a leading cause of death worldwide. The team discovered a new molecular pathway responsible for causing heart failure and showed that a first-in-class prototype drug, JQ1, blocks this pathway to protect the heart from damage.

2 Aug 2013

New type of chemical modification affects proteins, could provide insights into causes of cancer

Scientists at The Scripps Research Institute (TSRI) have discovered a new type of chemical modification that affects numerous proteins within mammalian cells. The modification appears to work as a regulator of important cellular processes including the metabolism of glucose.

2 Aug 2013

Researchers study how human herpes virus packages genetic information during infection

An international collaboration of researchers including Felicia Goodrum of the University of Arizona's immunobiology department has studied how a human herpes virus carried by the majority of the population packages its genetic information during infection.

31 Jul 2013

New way of looking at DNA

Stem cell genes seek each other in the cell nucleus. So a study by the Hubrecht Institute in Utrecht, the Netherlands, has found, published this week in Nature. “It’s a new way of looking at DNA.”

26 Jul 2013

Discovery of pressure-driven infection mechanism opens door to new treatments for viral infections

The virus that causes those painful lip blisters known as cold sores has an internal pressure eight times higher than a car tire, and uses it to literally blast its infectious DNA into human cells, scientists are reporting in a new study.

25 Jul 2013

OracleBio to highlight Oncology image analysis expertise at Tumor Models conference

OracleBio, providers of high precision digital image analysis services for detailed quantification of histological marker staining within cells and tissues, is pleased to announce it will be a principal sponsor of the forthcoming Tumor Models conference to be held in Boston, MA on the 23-25th July.

24 Jul 2013

Discovery may help explain how anti-inflammatory steroid drugs work

A gene long presumed dead comes to life under the full moon of inflammation, Stanford University School of Medicine scientists have found.

23 Jul 2013