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Researchers create the most detailed 3D maps of the human genome

In a landmark effort to understand how the physical structure of our DNA influences human biology, Northwestern investigators and the 4D Nucleome Project have unveiled the most detailed maps to date of the genome's three‑dimensional organization across time and space, according to a new study published in Nature.

22 Dec 2025

A senescence-based therapeutic approach for temporal lobe epilepsy

Temporal lobe epilepsy, which results in recurring seizures and cognitive dysfunction, is associated with premature aging of brain cells.

22 Dec 2025

Whole-body imaging reveals where drugs bind at single-cell resolution

When you take a drug, where in your body does it actually go? For most medications, scientists can make only educated guesses about the answer to this question.

22 Dec 2025

Altered stress signaling helps explain relapse in alcohol use disorder

A new study by Scripps Research reveals that alcohol dependence disrupts two signaling pathways in a stress-related part of the brain-and offers insights on developing drugs to treat this condition.

22 Dec 2025

Cells balance protein production and removal through passive adaptation

Every cell depends on proteins to function and stay healthy. These proteins are made inside the cell from amino acids but cannot simply accumulate inside the cell forever.

22 Dec 2025

Fatty diets reprogram hepatocytes and increase liver cancer risk

One of the biggest risk factors for developing liver cancer is a high-fat diet. A new study from MIT reveals how a fatty diet rewires liver cells and makes them more prone to becoming cancerous.

22 Dec 2025

Remodeling the tumor microenvironment to unlock CAR-T cell potential

Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized hematologic cancer treatment, but its efficacy in solid tumors remains limited by poor infiltration into the complex tumor microenvironment (TME).

22 Dec 2025

ARB drugs lead to better blood pressure treatment adherence

Patients who start their blood pressure treatment with ARB drugs continue with the same medicine to a greater extent than patients who start out with other drugs.

22 Dec 2025

Study charts the escalating spread of resistant bacteria and fungi

The success of modern medicine rests on the ability to control infections. But decades of antibiotic overuse—in hospitals, communities, and farms—have fueled a global surge in resistant microbes.

22 Dec 2025

New grant supports research into drug-induced brain toxicity

Important FDA-approved drugs to treat HIV and cancer can save lives, but they come with their own risks. Some drugs used clinically are known to cause neurological side effects in up to half of patients, ranging from confusion and memory problems to permanent nerve damage.

19 Dec 2025

New insights into how a molecular gatekeeper controls early protein modification

For years, ETH researchers have been investigating a molecular complex that plays a key role in protein synthesis. They have now discovered that this complex also contributes a crucial function in ensuring that our DNA is properly processed and “packaged”.

19 Dec 2025

ACE2 protein may play a protective role against high blood pressure and type 2 diabetes

A collaborative study from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London has found that the protein ACE2 may play a protective role against two common conditions, high blood pressure and type-2 diabetes, which affect millions of people worldwide.

19 Dec 2025

FDA warns against fake treatments for infertility

You may know someone who has been unable to get pregnant due to infertility issues. According to the Centers for Disease Control and Prevention, about 12 percent of women aged 15 to 44 in the United States have difficulty becoming pregnant or carrying a pregnancy to term.

19 Dec 2025