Fracture News and Research

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IMRT facilitates radiation dose escalation without compromising long-term morbidity for prostate cancer

In an analysis of three different types of radiation therapy used to treat localized prostate cancer, compared with conformal radiation therapy, intensity-modulated radiation therapy (IMRT) was associated with fewer diagnoses of gastrointestinal adverse effects, hip fractures, and receipt of additional cancer treatments but more erectile dysfunction, while proton therapy was associated with more gastrointestinal adverse effects than IMRT.

18 Apr 2012

Anaesthetists identify major shortfall in funding for emergency laparotomies

Anaesthetists have identified a major shortfall in funding for emergency laparotomies in England and have called for a national database to establish a more accurate picture of outcomes and costs. Figures published in the May issue of Anaesthesia suggest a shortfall of -300 million per year for emergency midline general surgical laparotomies, 32% of the total cost of care.

18 Apr 2012

Researchers identify 56 genetic variants that influence BMD

Researchers at The Institute for Aging Research at Hebrew SeniorLife, an affiliate of Harvard Medical School, have co-authored the largest meta-analysis of genome-wide association studies of osteoporosis as part of an international consortium and have identified dozens of genetic variants found to be linked to an increased risk of developing osteoporosis and of suffering broken bones.

17 Apr 2012

Football-related brain injuries appear to rise among high school students

Catastrophic brain injuries associated with full-contact football appear to be rising, especially among high school students, according to a new report.

17 Apr 2012

32 genetic variations could play a role in osteoporosis risk

A team of international researchers have found 32 new genetic regions linked to fractures and osteoporosis. According to the new study published in the April 15 online edition of Nature Genetics, changes in these regions could offer protection from, or greater risk for, bone-weakening disease.

16 Apr 2012

$Researchers identify 32 genetic regions associated with osteoporosis, fracture$

Researchers identify 32 genetic regions associated with osteoporosis, fracture

Thirty-two previously unidentified genetic regions associated with osteoporosis and fracture have been identified by a large, worldwide consortium of researchers, including Stanford Prevention Research Center chief John Ioannidis, MD, DSc. Variations in the DNA sequences in these regions confer either risk or protection from the bone-weakening disease. Many, but not all, of the regions encode proteins involved in pathways known to involve bone health.

16 Apr 2012

Study reveals genetic predictors of bone health and osteoporosis

An international consortium of researchers have identified a group of genes associated with the development of osteoporosis, a debilitating bone disease that cripples more than 10 million Americans a year and costs the U.S. healthcare system an estimated $17 billion annually.

16 Apr 2012

Amgen, UCB commence CDP7851/AMG 785 Phase 3 trial in postmenopausal osteoporosis

UCB and Amgen announced today the start of their sclerostin antibody (CDP7851/AMG 785) Phase 3 clinical trial program for the treatment of postmenopausal osteoporosis.

4 Apr 2012

ECTS, IOF publish guidance document to manage GIO

Oral glucocorticoids are commonly prescribed for a wide variety of disorders, most commonly for rheumatoid arthritis, obstructive pulmonary disease and inflammatory bowel diseases. However, the use of these medications can result in rapid bone loss during the first three to six months of therapy, leading to increased risk of fragility fractures.

28 Mar 2012

Specific precautions must be taken for individuals on longer-term oral glucocorticoid therapy

Millions of people around the world are prescribed glucocorticoids for a wide variety of inflammatory conditions, including, rheumatoid arthritis, asthma and inflammatory bowel diseases. Although they are effective and widely used, one of the potentially serious side effects of these medications is glucocorticoid-induced osteoporosis.

28 Mar 2012

Boniva generics receive FDA approval for treatment, prevention of osteoporosis

The U.S. Food and Drug Administration today approved the first generic versions of Boniva (ibandronate) tablets, a once-monthly product to treat or prevent osteoporosis in women after menopause.

27 Mar 2012

UK researcher receives IOF-Servier Young Investigator Research Grant

The IOF-Servier Young Investigator Research Grant has been awarded to Dr Mark Edwards, clinical research fellow at the MRC Lifecourse Epidemiology Unit at Southhampton General Hospital in the UK.

27 Mar 2012

New compendium on head injury biomechanics

SAE International offers a 3-volume set Head Injury Biomechanics, edited by Jeffrey A. Pike, which is designed to aid those studying head injury from a broad range of causes, including transportation, falls, sports, personal violence, and blast-related.

26 Mar 2012

Early growth predicts strength of the hip bone in childhood

Researchers from the MRC Lifecourse Epidemiology Unit, University of Southampton, have presented evidence that early growth predicts the size, mineralisation, shape and strength of the hip bone in childhood.

26 Mar 2012

$Economic burden of fragility fractures in Europe far exceeds previous estimates$

Economic burden of fragility fractures in Europe far exceeds previous estimates

Researchers at the European Congress of Osteoporosis & Osteoarthritis in Bordeaux have presented new data * which shows that the economic burden of fragility fractures in the 27 member states of the European Union far exceeds previous estimates, with hip fractures accounting for around 55% of costs.

26 Mar 2012

Osteoporosis researcher receives IOF Medal of Achievement

Today, at the European Congress on Osteoporosis & Osteoarthritis, Professor Cyrus Cooper was awarded the International Osteoporosis Foundation (IOF) Medal of Achievement.

26 Mar 2012

Immediate skull reconstruction aggravates brain damage in TBI model

Immediate skull reconstruction following trauma that penetrates or creates an indentation in the skull can aggravate brain damage inflicted by the initial injury, a study by a University of South Florida research team reports.

23 Mar 2012

Thromboembolic events can occur after musculoskeletal injury and related surgery

Below is a news summary of an orthopaedic research study appearing in the March 21, 2012 issue of the Journal of Bone and Joint Surgery (JBJS), as well as the issues' full Table of Contents.

22 Mar 2012

$Large geographic variation in risk of hip fracture$

Large geographic variation in risk of hip fracture

An extensive study of country-specific risk of hip fracture and 10-year probability of a major fragility fracture has revealed a remarkably large geographic variation in fracture risk. Even accounting for possible errors or limitations in the source data, there was an astonishing 10-fold variation in hip fracture risk and fracture probability between countries.

22 Mar 2012