Inflammatory Disease News and Research

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Molecular switch may help fight off MRSA

The discovery of a 'molecular switch' could lead to new ways of treating infections such as MRSA, and inflammatory diseases like arthritis.

27 Apr 2005

Short segments of sugar chains useful in search for new drugs for Alzheimer's

Heparansulfate, which is needed for normal fetal development among other things, is also important for the build-up of amyloid, morbid protein deposits that appear in several serious diseases. This is shown by Uppsala scientists in an article published in the Proceedings of the National Academy of Science.

19 Apr 2005

Stress can give the immune system a beneficial boost

New research in mice provides more evidence that a brief bout of stress can give the immune system a beneficial boost – under certain conditions.

19 Apr 2005

Animi-3 may offer hope for rheumatoid arthritis

Animi-3, a prescription medication from PBM Pharmaceuticals, Inc., contains ingredients that may have a beneficial, protective effect in inflammatory diseases such as rheumatoid arthritis (RA).

7 Apr 2005

Why smokers lung is resistant to steroid treatment

UK researchers think they are close to finding the first effective treatment to fight one of the biggest killer diseases in the UK. Professor Peter Barnes will present the work at the British Endocrine Societies 2005 meeting in Harrogate.

4 Apr 2005

Mutations in the HFE gene directly associated with chronic joint disease

Mutations in the HFE gene, which is involved in iron regulation, seem to be directly associated with chronic joint disease (or haemophilic arthropathy) among haemophilic patients, claim a team of Portuguese scientists in the April issue of the journal Blood.

4 Apr 2005

Asthma patients' immune systems respond differently with allergies

Researchers from the University of Chihuahua in Mexico report that immune systems of patients with asthma responded differently to a common laboratory challenge, depending on whether their white blood cells had been obtained during a time when they were suffering from common season allergic rhinitis or when they were free of such allergic symptoms.

3 Apr 2005

Process for disposal of dying neutrophils actively linked to neutrophil production

New research identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction.

23 Mar 2005

Discovery may provide a new target to treat sepsis

Part of the immune system's pro-inflammatory response to bacterial invasion is to increase nitric oxide levels with an enzyme called inducible nitric oxide synthase.

14 Mar 2005

Mouse gene shows new mechanism behind cardiac infarction in man

A gene that, in different variants, increases or decreases the level of atherosclerosis has been identified in mice. The corresponding human gene has been shown to play a role in the development of myocardial infarction.

9 Mar 2005

Theory that could help to cure diseases including cancer

An Open University science student has astonished the world of medicine with a theory that could help to cure diseases including cancer.

21 Dec 2004

Millennium Pharmaceuticals discovers protein biomarkers that could play a role in the early detection of rheumatoid arthritis

Researchers at Millennium Pharmaceuticals today announced the discovery of a panel of protein biomarkers that could play a role in the early detection, prognosis and monitoring of rheumatoid arthritis (RA).

14 Dec 2004

FDA accepts Genmab's Investigational New Drug Application for active rheumatoid arthritis treatment

Genmab announced today the US Food and Drug Administration (FDA) accepted its Investigational New Drug Application (IND) to start a Phase I/II dose escalation trial for HuMax-CD20 to treat patients with active rheumatoid arthritis (RA) who have failed one treatment with one or more disease modifying anti-rheumatic drugs (DMARDs).

13 Dec 2004

FDA approval of cream to treat bacterial vaginosis

KV Pharmaceutical Company has announced that it has received approval from the United States Food and Drug Administration (FDA) to market Clindesse (clindamycin phosphate) Vaginal Cream, 2%, a single-dose prescription cream therapy indicated to treat bacterial vaginosis ("BV").

3 Dec 2004

Red meat consumption is an independent risk factor in the development of inflammatory arthritis

A chronic inflammatory disease of the immune system, rheumatoid arthritis (RA) has been linked to a combination of genetic and environmental factors.

2 Dec 2004

Gene protects against environmental pollutants and pulmonary emphysema

Researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions have identified a “master gene” in mice that controls the action of 50 other genes whose products protect the lungs against environmental pollutants.

17 Nov 2004

Abbott's investigational anti-interleukin-12 fully human monoclonal antibody in Crohn's disease study

Results of a Phase II study of Abbott's ABT-874, a fully human anti-interleukin-12 (IL-12) monoclonal antibody, will appear tomorrow in the New England Journal of Medicine citing treatment with ABT-874 shows differences in response and remission in patients with active Crohn's disease compared to placebo, in one arm of the study.

10 Nov 2004