Tumor News and Research

RSS

Study reveals presence of new genetic mutation in melanoma cancer cells

There is strong evidence that the protein complex APC/C may function as a tumor suppressor in multiple cancers including lymphoma, colorectal and breast cancer, and now melanoma. A new study has revealed that a genetic mutation leading to repression of a specific protein, Cdh1, which interacts with APC/C, is present in melanoma cancer cells.

3 Sep 2015

Incorporating clinical genomic sequencing data into clinical management improves pediatric cancer treatment

In a study that included children and young adults with relapsed or refractory cancer, incorporation of integrative clinical genomic sequencing data into clinical management was feasible, revealed potentially actionable findings in nearly half of the patients, and was associated with change in treatment and family genetics counseling for a small proportion of patients, according to a study in the September 1 issue of JAMA.

2 Sep 2015

UCLA scientists develop promising new combination treatment for glioblastoma

UCLA scientists have developed a potentially promising new combination therapy for glioblastoma, the deadliest form of brain cancer.

2 Sep 2015

Altering protein recycling complexes in human cells may help overcome chemotherapy resistance

Altering the protein recycling complexes in human cells, including cancer cells, allows the cells to resist treatment with a class of drugs known as proteasome inhibitors, according to Whitehead Institute scientists.

2 Sep 2015

U-M study suggests potential treatment options for children with aggressive, advanced cancer

For children with rare, aggressive and advanced cancer, precision medicine may help doctors determine their best treatment options, a new study finds.

2 Sep 2015

Treating cancer cells with quizartinib inhibits key metabolic pathway, activates macroautophagy

A study published in The Journal of Cell Biology describes a way to force cancer cells to destroy a key metabolic enzyme they need to survive.

1 Sep 2015

Affinity tuning can make CAR T cells spare normal cells and attack cancer cells

A new development in engineering chimeric antigen receptor (CAR) T cells, called affinity tuning, can make the CAR T cells spare normal cells and better recognize and attack cancer cells, which may help lower the toxicity associated with this type of immunotherapy when used against solid tumors, according to a preclinical study.

1 Sep 2015

Northwestern University receives $11.7 million NCI grant to use nanotechnology for cancer treatments

Northwestern University, a leader in cancer nanotechnology research, has received a five-year, $11.7 million grant from the National Cancer Institute to use nanotechnology to develop next-generation cancer treatments.

1 Sep 2015

MACC1 gene can help predict better treatment options for patients with Klatskin carcinoma

Bile duct cancer is rare and is usually detected too late. Often only extensive liver surgery can help or, in rare cases, liver transplantation. But which patients will benefit from surgery and which will not, because their risk of cancer recurrence is too high? With the oncogene MACC1 as a biomarker, physicians for the first time have a tool to decide which treatment option is best for patients with Klatskin carcinoma, one type of bile duct cancer.

1 Sep 2015

Regen BioPharma develops novel means of delivering RGBP-248 gene silencing nucleic acid to liver tumors

Regen BioPharma, Inc. announced today development of a novel means of delivering its patented (US Patent 8,263,571) gene silencing nucleic acid, RGBP-248, to liver tumors utilizing a clinically approved formulation as delivery system. The product in development overcomes previous hurdles with gene silencing therapeutics in which the gene silencing drug had to be delivered throughout the whole body.

31 Aug 2015

Brain tumor is not always the death sentence

Only half of brain cancers actually start in the brain. The rest - as in the case of former president Jimmy Carter - are metastatic tumors from cancer that originated elsewhere in the body.

29 Aug 2015

Synthetic tissue environment enables spatial definition of cancer cells and macrophages

Tumors are notoriously difficult to study in their natural habitat - body tissues - but a new synthetic tissue environment may give cancer researchers the next-best look at tumor growth and behavior.

29 Aug 2015

Keratin 17 protein plays crucial role in degrading key tumor suppressor protein

Keratin 17 (K17), a protein previously believed to provide only mechanical support for cancer cells, appears to play a crucial role in degrading a key tumor suppressor protein in cancer cells named p27. This finding, published in the September 1 issue of Cancer Research, is based on the work of researchers in the Department of Pathology at Stony Brook University School of Medicine.

29 Aug 2015

Fetal microchimerism could be a subtle and dizzyingly complex puzzle

Parents go to great lengths to ensure the health and well-being of their developing offspring. The favor, however, may not always be returned.

29 Aug 2015

Four UC San Diego researchers selected to receive newly established NCI Outstanding Investigator Award

Four University of California, San Diego School of Medicine researchers have been selected to receive the newly established National Cancer Institute (NCI) Outstanding Investigator Award. The multi-million dollar awards fund new projects that have an unusual potential in cancer research over seven years.

29 Aug 2015

Scientists uncover mechanism responsible for development of adrenal gland tumors

Scientists at the Helmholtz Zentrum München have elucidated a mechanism that is responsible for the development of adrenal gland tumors. They discovered that the BMP7 protein plays a key role in this process and that it could be a possible target for future treatments. The results have been published in the journal 'Oncotarget'.

28 Aug 2015

Researchers identify drugs that may enhance ability of TKI dasatinib to kill human cancer cells

Researchers have discovered how a common mutation in a high-risk leukemia subtype drives the cancer's aggressiveness and have identified drugs that may work with existing precision medicines to improve survival. St. Jude Children's Research Hospital scientists led the study, which was published online today in the journal Cancer Cell.

28 Aug 2015

Adaptive immune system plays active role in guiding development of mammary glands

In experiments with mouse tissue, UC San Francisco researchers have discovered that the adaptive immune system, generally associated with fighting bacterial and viral infections, plays an active role in guiding the normal development of mammary glands, the only organs--in female humans as well as mice--that develop predominately after birth, beginning at puberty.

28 Aug 2015

History of oral contraceptive use influences survival in ovarian cancer patients

A history of oral contraceptive use and having at least one child increased longevity by nearly three years in patients diagnosed with ovarian cancer, according to a Roswell Park Cancer Institute study recently published online ahead of print in the International Journal of Gynecological Cancer.

28 Aug 2015

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Working with human cancer cell lines and mice, researchers at the Johns Hopkins Kimmel Cancer Center and elsewhere have found a way to trigger a type of immune system "virus alert" that may one day boost cancer patients' response to immunotherapy drugs. An increasingly promising focus of cancer research, the drugs are designed to disarm cancer cells' ability to avoid detection and destruction by the immune system.

27 Aug 2015

Tumor News and Research

Study reveals presence of new genetic mutation in melanoma cancer cells

Incorporating clinical genomic sequencing data into clinical management improves pediatric cancer treatment

UCLA scientists develop promising new combination treatment for glioblastoma

Altering protein recycling complexes in human cells may help overcome chemotherapy resistance

U-M study suggests potential treatment options for children with aggressive, advanced cancer

Treating cancer cells with quizartinib inhibits key metabolic pathway, activates macroautophagy

Affinity tuning can make CAR T cells spare normal cells and attack cancer cells

Northwestern University receives $11.7 million NCI grant to use nanotechnology for cancer treatments

MACC1 gene can help predict better treatment options for patients with Klatskin carcinoma

Regen BioPharma develops novel means of delivering RGBP-248 gene silencing nucleic acid to liver tumors

Brain tumor is not always the death sentence

Synthetic tissue environment enables spatial definition of cancer cells and macrophages

Keratin 17 protein plays crucial role in degrading key tumor suppressor protein

Fetal microchimerism could be a subtle and dizzyingly complex puzzle

Four UC San Diego researchers selected to receive newly established NCI Outstanding Investigator Award

Scientists uncover mechanism responsible for development of adrenal gland tumors

Researchers identify drugs that may enhance ability of TKI dasatinib to kill human cancer cells

Adaptive immune system plays active role in guiding development of mammary glands

History of oral contraceptive use influences survival in ovarian cancer patients

Researchers find way to trigger 'virus alert' that may help boost drug's ability to prevent cancer cells

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Latest News