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Studies examine how PML gene regulates the fatty acid oxidation pathway

Two papers led by scientific teams from the Cancer Genetics Program at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms underlying cellular energy and metabolism and, at the same time, highlight both the challenges and opportunities of genetic approaches to cancer treatment.

31 Aug 2012

PD0325901 drug may hold potential to prevent neurofibromatosis 1 in children

A drug originally developed to stop cancerous tumors may hold the potential to prevent abnormal brain cell growth and learning disabilities in some children, if they can be diagnosed early enough, a new animal study suggests.

31 Aug 2012

UMHS, MidMichigan Health announce plans to affiliate as clinical and business partners

MidMichigan Health and the University of Michigan Health System have announced plans to affiliate as clinical and business partners.

29 Aug 2012

Gilead Sciences receives FDA approval for Stribild to treat HIV-1 infection

Gilead Sciences, Inc. announced today that the U.S. Food and Drug Administration (FDA) has approved Stribild (elvitegravir 150 mg/cobicistat 150 mg/emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg), a complete once-daily single tablet regimen for HIV-1 infection for treatment-naïve adults.

28 Aug 2012

Profilin-1 gene influences survival time in Lou Gehrig's disease

A team of scientists, including faculty at the University of Massachusetts Medical School (UMMS), have discovered a gene that influences survival time in amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease).

27 Aug 2012

$LCZ696 demonstrates beneficial effects in heart failure patients with preserved ejection fraction$

LCZ696 demonstrates beneficial effects in heart failure patients with preserved ejection fraction

The novel angiotensin receptor neprilysin inhibitor, LCZ696, demonstrated beneficial effects in heart failure patients with preserved ejection fraction (HFpEF), according to results of the PARAMOUNT (Prospective compArison of ARNI with ARB on Management Of heart failUre with preserved ejectioN fracTion) trial.

27 Aug 2012

Mexican-Americans with ancestral links have higher insulin resistance levels

Mexican-Americans with an ancestral link to Amerindian tribes were found to have higher insulin resistance levels, which is an indication of several chronic conditions such as type 2 diabetes, according to research by The University of Texas Health Science Center at Houston (UTHealth).

26 Aug 2012

Children more likely to pick up stomach infections from private water supplies

Children drinking from around half the UK's private water supplies are almost five times more likely to pick up stomach infections - according to research from the University of East Anglia (UEA).

26 Aug 2012

Personalized colon cancer therapy based on genetics of specific cancer

University of Minnesota Medical School and Masonic Cancer Center researchers have partnered with geneticists from Genentech, Inc., to discover how some proteins may cause the development of some forms of colon cancers.

24 Aug 2012

Pre-emptive therapy better than valacyclovir prophylaxis in treating CMV in transplant recipients

Waiting to treat the commonest viral infections in transplant recipients until they reach a certain threshold is better than prophylactically treating all recipients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

24 Aug 2012

Abnormalities in mitochondrial length promote development of neurodegenerative diseases

Goldilocks was on to something when she preferred everything "just right." Harvard Medical School researchers have found that when it comes to the length of mitochondria, the power-producing organelles, applying the fairy tale's mantra is crucial to the health of a cell. More specifically, abnormalities in mitochondrial length promote the development of neurodegenerative diseases such as Alzheimer's.

24 Aug 2012

Trainee surgeons in operations is safe according to new study

A high profile study involving researchers at the University of Limerick's Graduate Entry Medical School has shown that surgical operations in which surgeons-in-training are involved are as safe as operations performed in which trainees have no operative role. The new study addressed earlier studies which raised concerns that the presence of surgeons-in-training may raise the level of risk involved.

22 Aug 2012

Miniaturized wireless sensors can save lives of wounded soldiers

Early detection of blood loss to save the lives of soldiers wounded on the battlefield is the goal of a three-year research and development project to be launched this fall at Worcester Polytechnic Institute (WPI). Funded by a $1.9 million grant from the U.S. Army, the research will be conducted in collaboration with the University of Massachusetts Medical School (UMMS).

22 Aug 2012

Clinical trial to test whether fecal transplantation is effective in treating relapsing C. difficile

For patients with Clostridium difficile (C. difficile), a persistent and potentially deadly bacterial illness, severe diarrhea, abdominal pain, nausea and vomiting are an everyday event. This particularly virulent infection is prone to recurrence, even after multiple courses of expensive antibiotics, and treatment options are limited for patients who continually relapse or develop antibiotic resistance.

22 Aug 2012

Mof protein plays a key role in epigenetics of stem cells

How do stem cells preserve their ability to become any type of cell in the body? And how do they "decide" to give up that magical state and start specializing? If researchers could answer these questions, our ability to harness stem cells to treat disease could explode. Now, a University of Michigan Medical School team has published a key discovery that could help that goal become reality.

22 Aug 2012

Study identifies how genetic mutations in the nervous system cause Duane Syndrome

A research team from King's College London and the University of Exeter Medical School has identified how a genetic mutation acts during the development of nerves responsible for controlling eye muscles, resulting in movement disorders such as Duane Syndrome, a form of squint.

22 Aug 2012

CIRT to determine whether methotrexate can reduce heart attacks, strokes and CVD deaths

An international multi-site trial has launched to determine whether a common anti-inflammatory drug can reduce heart attacks, strokes, and deaths due to cardiovascular disease in people at high risk for them. This study is being supported by the National Heart, Lung, and Blood Institute (NHLBI), a part of the National Institutes of Health.

22 Aug 2012

NIAID announces 14 grants for basic research to identify new HIV vaccine approaches

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded 14 grants totaling $7.8 million in first-year funding for basic research to identify new approaches for designing a safe and effective HIV vaccine.

22 Aug 2012

Vitamin D may help fight childhood acute respiratory infections

Supplementation with vitamin D, particularly in winter, appears to reduce a child’s risk for contracting acute respiratory infections by almost 50%, show results from a Mongolian study.

21 Aug 2012

Neurally-interfaced hand prosthesis re-establishes communication between nervous systems

Amputation disrupts not only the peripheral nervous system but also central structures of the brain. While the brain is able to adapt and compensate for injury in certain conditions, in amputees the traumatic event prevents adaptive cortical changes. A group of scientists reports adaptive plastic changes in an amputee's brain following implantation of multielectrode arrays inside peripheral nerves.

21 Aug 2012

Medical School News and Research

Studies examine how PML gene regulates the fatty acid oxidation pathway

PD0325901 drug may hold potential to prevent neurofibromatosis 1 in children

UMHS, MidMichigan Health announce plans to affiliate as clinical and business partners

Gilead Sciences receives FDA approval for Stribild to treat HIV-1 infection

Profilin-1 gene influences survival time in Lou Gehrig's disease

LCZ696 demonstrates beneficial effects in heart failure patients with preserved ejection fraction

Mexican-Americans with ancestral links have higher insulin resistance levels

Children more likely to pick up stomach infections from private water supplies

Personalized colon cancer therapy based on genetics of specific cancer

Pre-emptive therapy better than valacyclovir prophylaxis in treating CMV in transplant recipients

Abnormalities in mitochondrial length promote development of neurodegenerative diseases

Trainee surgeons in operations is safe according to new study

Miniaturized wireless sensors can save lives of wounded soldiers

Clinical trial to test whether fecal transplantation is effective in treating relapsing C. difficile

Mof protein plays a key role in epigenetics of stem cells

Study identifies how genetic mutations in the nervous system cause Duane Syndrome

CIRT to determine whether methotrexate can reduce heart attacks, strokes and CVD deaths

NIAID announces 14 grants for basic research to identify new HIV vaccine approaches

Vitamin D may help fight childhood acute respiratory infections

Neurally-interfaced hand prosthesis re-establishes communication between nervous systems

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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