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Scientists shed light on the roll of junk DNA

University of Iowa scientists have made a discovery that broadens understanding of a rapidly developing area of biology known as functional genomics and sheds more light on the mysterious, so-called "junk DNA" that makes up the majority of the human genome.

13 Nov 2006

Safety of t-PA clot-busting therapy questioned

Across the world, emergency medical teams often administer a powerful clot-busting drug called tissue plasminogen activator (t-PA) to help patients stricken by heart attack.

13 Nov 2006

Scientists discover how androgen plays a role in the development of prostate cancer

Scientists have discovered for the first time a specific biochemical pathway by which the sex hormone, androgen, increases levels of harmful chemicals called reactive oxygen species (ROS) in the prostate gland that play a role in the development of prostate cancer.

8 Nov 2006

Compound in red wine counters effects of a high-calorie diet

The results of an international study suggests that a compound found in red wine gave mice longer and healthier lives and also countered some of the effects of a high-calorie diet.

1 Nov 2006

Botswana launches infant HIV testing program

Botswana in a ceremony in Francistown -- attended by Mark Dybul, who serves as the U.S. global AIDS coordinator and administers the President's Emergency Plan for AIDS Relief -- launched a program to test six-month-old infants for HIV, according a U.S. embassy statement released on Wednesday, SAPA/SABC News reports.

30 Oct 2006

Lab-on-a-chip nanoscale array monitors cellular processes

Researchers at Tel-Aviv University in Israel have developed a lab-on-a-chip device that can incorporate enzymes and even living cells in a nanoscale array capable of monitoring electrochemical reactions.

30 Oct 2006

Detecting rare microRNAs with gold nanoparticles

Over the past three years, numerous studies have shown that short pieces of single-stranded RNA, known as microRNAs, play a central role in the development of at least some cancers.

30 Oct 2006

Scientists step toward next generation of cancer-beating drugs

Scientists helping to develop the next generation of cancer-beating drugs say they have had a major breakthrough with their latest results.

From The University of Manchester 26 Oct 2006

Twisted molecule, large and folded like a protein - but completely synthetic

The physiological functions of proteins depend on their folding into a particular spatial structure (tertiary structure): enzymes and their substrates must fit together like the proverbial lock and key.

26 Oct 2006

FDA approves Tyzeka for the treatment of adults with chronic hepatitis B

The Food and Drug Administration (FDA) has approved Tyzeka (telbivudine) for the treatment of adults with chronic hepatitis B (HBV), a serious viral infection that attacks the liver and can cause lifelong infection, scarring of the liver (cirrhosis), and eventually liver cancer, liver failure, and death.

26 Oct 2006

Squalenoyl nanomedicines as potential therapeutics

Nucleoside analogs such as cytarabine and gemcitabine are powerful anticancer agents, but a simple chemical modification that causes them to assemble into stable nanoparticles could make them even more valuable in the treatment of a wide variety of cancers.

23 Oct 2006

Gene mutation explains type of brittle bone disease

A newly identified gene mutation helps explain a subset of cases of osteogenesis imperfecta (OI), or brittle bone disease, whose origin had until now remained mysterious.

20 Oct 2006

Flexible interface between DNA ligase and a heterotrimeric sliding clamp supports conformational switching and efficient ligation of DNA

Scientists investigating an important DNA-repair enzyme now have a better picture of the final steps of a process that glues together, or ligates, the ends of DNA strands to restore the double helix.

20 Oct 2006

Important first step towards designing new therapies for shingles

A team of scientists at the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), has identified a human protein that helps varicella-zoster virus, the cause of chickenpox and shingles, spread from cell to cell within the body.

20 Oct 2006

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

Using a combination of enzyme activity and metabolite profiling, we determined that this protein-whose function was previously unknown-serves as a key regulator of a lipid signaling network that contributes to cancer," said Benjamin F. Cravatt, a Scripps Research professor and a member of its Skaggs Institute for Chemical Biology who led the study.

20 Oct 2006

Heart transplant patients who receive a donor heart from a person with hepatitis C have a lower rate of survival

A shortage of cardiac organ donors results in a substantial number of deaths among persons awaiting cardiac transplantation. One potential approach for increasing the availability of donors is to broaden the criteria used to identify appropriate donors.

17 Oct 2006

FDA approves Januvia for diabetes

The Food and Drug Administration (FDA) announced today the approval of Januvia (sitagliptin phosphate) Tablets, the first diabetes treatment approved in a new class of drugs known as DDP-4 inhibitors that enhances the body's own ability to lower elevated blood sugar.

17 Oct 2006

Researchers identifiy how immune system contributes to nerve fiber damage caused by multiple sclerosis

Researchers have identified how the body's own immune system contributes to the nerve fiber damage caused by multiple sclerosis, a finding that can potentially aid earlier diagnosis and improved treatment for this chronic disease.

16 Oct 2006

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

The interactions between proteins and nucleic acids play a critical role in some of life’s most crucial biochemical processes, including gene expression and protein production, and some promising anticancer agents exert their effects by interfering with these interactions.

16 Oct 2006