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Chimeric reference standards for validating controls in SARS-CoV-2 tests

A preliminary study by researchers from the Garvan Institute of Medical Research and the University of New South Wales and published on the preprint server bioRxiv in June 2020 reports the use of chimeric design to produced reference standards for diagnostic tests. This could allow a highly flexible approach to the development of different genetic features in the same test, even for organisms that are not directly related.

15 Jun 2020

Study aims to identify key genes involved in the body's response to COVID-19 infection

Data from popular home genetic-testing kits could help scientists shed light on why some people who catch coronavirus have no symptoms while others become very ill.

15 Jun 2020

New MRI techniques can improve outcomes in patients with Parkinson's disease

Recently developed MRI techniques used to more precisely target a small area in the brain linked to Parkinson's disease and essential tremor may lead to better outcomes without surgery and with less risk of negative effects, a new study led by UT Southwestern researchers suggests.

15 Jun 2020

Steroidal drugs subvert SARS-CoV-2 interaction with ACE2 receptors

A new study by Italian researchers and published online on the preprint server bioRxiv* in June 2020 reports the ability of several existing steroidal drugs to reduce the binding of the SARS-CoV-2 to the ACE2 receptor. This could help define newer strategies using viral entry blockers to reduce viral load.

14 Jun 2020

Effect of human genes on severity and infectivity of SARS-CoV-2

Now, a new paper published on the preprint server medRxiv* reports the results of an analysis of the association between the genetic variants in the patients and the clinical progression of the disease. The study included 332 patients hospitalized with COVID-19 in a single-center, with widely varying laboratory and clinical features. There were 25, 12, and 17 patients with asymptomatic, mild, and critical disease.

14 Jun 2020

New test can detect the RNA of SARS-CoV-2 in patient samples in 30 minutes

A new diagnostic test can detect the RNA of SARS-CoV-2, the virus that causes COVID-19, in urine, blood, saliva or mouth swab samples in just 30 to 45 minutes, according to a new study published June 12, 2020 in the open-access journal PLOS ONE by Laura Lamb of the Beaumont Health System, Michigan, USA, and colleagues.

14 Jun 2020

Study reveals protein responsible for vulnerability in cancer cells

A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

14 Jun 2020

Study: Parasite infection closely linked to the make-up of gastrointestinal microbiome

Parasite infections are a constant presence for many people who live in tropical regions, particularly in less industrialized areas.

14 Jun 2020

JRC creates a database of COVID-19 diagnostic devices and test methods

As part of EU efforts to provide guidance on the use of coronavirus tests, the JRC has created a database of COVID-19 in vitro diagnostic devices and test methods that gathers information on available tests in one place.

12 Jun 2020

Damon Runyon Cancer Research Foundation awards $3.2 million to early-career physician-scientists

The Damon Runyon Cancer Research Foundation has named four new Damon Runyon Clinical Investigators.

12 Jun 2020

Human cardiac organoids for modeling physiological conditions during a heart attack

In the U.S., someone has a heart attack every 40 seconds, and yet researchers have not had a model that fully mimics what occurs in the human heart after a heart attack.

12 Jun 2020

Genetic risk score is effective in diagnosing type 1 diabetes in Indians

A new way of using genetics to diagnose diabetes could pave the way for better diagnosis and treatment in Indians, new research has concluded.

12 Jun 2020

Texas Heart Institute and 7 Hills Pharma receive $1.9 million to improve stem cell transplants

The Texas Heart Institute and 7 Hills Pharma received a $1.9 million, Phase II STTR (R42) grant from the National Heart Lung Blood Institute to advance further their lead product 7HP349, a novel integrin activator, to define the optimal dosing schedule for cord blood transplant along with a focus on development and production of a formulation that meets safety standards for filing an IND application with the FDA.

12 Jun 2020

MGH researchers identify key mechanism in X chromosome inactivation

Researchers at Massachusetts General Hospital have identified a key mechanism in X chromosome inactivation, a phenomenon that may hold clues that lead to treatments for certain rare congenital disorders.

12 Jun 2020

Scientists find potential new way to improve treatment for Von Willebrand Disease

Scientists have found a potential new way to promote blood clotting that could be used to help develop treatments for Von Willebrand Disease, the most common genetic bleeding disorder.

12 Jun 2020

Genomic analysis of medieval skeletons has important implications for syphilis history in Europe

Mass burials are common remnants of the many plague outbreaks that ravaged Medieval Europe. A number of these graveyards are well documented in historical sources, but the locations of most, and the victims they contain, have been lost to the pages of time. In Vilnius, Lithuania, one such cemetery was found in a typical way: accidental discovery during a routine city construction project.

12 Jun 2020

Researchers are developing statistical tools to analyze the spread and evolution of coronavirus

For as much as the scientific community has learned about the novel coronavirus, SARS-CoV-2, since it emerged in China last year, many key aspects of the pandemic remain a mystery.

12 Jun 2020

Ashion Analytics is now part of NCI's MATCH cancer clinical trials

Ashion Analytics, a clinical laboratory of the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, is now part of the National Cancer Institute's MATCH program, which provides patients who have rare or difficult-to-treat cancers with access to unique clinical trials nationwide that might give them the best therapeutic treatments and outcomes.

12 Jun 2020

Researchers question the mechanism of retinitis pigmentosa

Researchers who made a knock-in mouse-model of the genetic disorder retinitis pigmentosa 59, or RP59, expected to see retinal degeneration and retinal thinning. As reported in the journal Cells, they surprisingly found none, calling into question the commonly accepted -- though never proved -- mechanism for RP59.

12 Jun 2020

Aspirin reduces hereditary colorectal cancer risk

Aspirin reduces colorectal cancer risk by half in individuals at high genetic risk. Preventive efficacy is prolonged for 10-20 years after treatment with aspirin.

11 Jun 2020

Genetic News and Research

Chimeric reference standards for validating controls in SARS-CoV-2 tests

Study aims to identify key genes involved in the body's response to COVID-19 infection

New MRI techniques can improve outcomes in patients with Parkinson's disease

Steroidal drugs subvert SARS-CoV-2 interaction with ACE2 receptors

Effect of human genes on severity and infectivity of SARS-CoV-2

New test can detect the RNA of SARS-CoV-2 in patient samples in 30 minutes

Study reveals protein responsible for vulnerability in cancer cells

Study: Parasite infection closely linked to the make-up of gastrointestinal microbiome

JRC creates a database of COVID-19 diagnostic devices and test methods

Damon Runyon Cancer Research Foundation awards $3.2 million to early-career physician-scientists

Human cardiac organoids for modeling physiological conditions during a heart attack

Genetic risk score is effective in diagnosing type 1 diabetes in Indians

Texas Heart Institute and 7 Hills Pharma receive $1.9 million to improve stem cell transplants

MGH researchers identify key mechanism in X chromosome inactivation

Scientists find potential new way to improve treatment for Von Willebrand Disease

Genomic analysis of medieval skeletons has important implications for syphilis history in Europe

Researchers are developing statistical tools to analyze the spread and evolution of coronavirus

Ashion Analytics is now part of NCI's MATCH cancer clinical trials

Researchers question the mechanism of retinitis pigmentosa

Aspirin reduces hereditary colorectal cancer risk

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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