DNA Damage News and Research

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Researcher receives grant to explore HER2-positive breast tumor susceptibility to PARP inhibitors

Shih-Hsin (Eddy) Yang, M.D., Ph.D., the ROAR Southeast Cancer Foundation Endowed Chair in the University of Alabama at Birmingham Department of Radiation Oncology, has received a $450,000 grant from Susan G. Komen for the Cure to further investigate HER2-positive breast tumor susceptibility to PARP inhibitors.

10 Oct 2013

Genomic instability in CFS is associated with less favorable outcome in patients with CaP

Detailed evaluation of a prostate cancer tumor biopsy may predict treatment outcomes for image-guided radiation therapy (IGRT) or surgery for prostate cancer, according to research presented today at the American Society for Radiation Oncology's (ASTRO's) 55th Annual Meeting.

27 Sep 2013

TSRI scientists discover process by which special immune cells in skin help heal wounds

Scientists at The Scripps Research Institute (TSRI) have discovered an important process by which special immune cells in the skin help heal wounds. They found that these skin-resident immune cells function as "first responders" to skin injuries in part by producing the molecule known as interleukin-17A (IL-17A), which wards off infection and promotes wound healing.

27 Sep 2013

'Jekyll-and-Hyde' protein could be potent target for developing new cancer drugs

The mood changes of a 'Jekyll-and-Hyde' protein, which sometimes boosts tumour cell growth and at other times suppresses it, have been explained in a new study led by Oxford University researchers.

27 Sep 2013

Apple impregnated with tangerine juice reduces risk of cardiovascular disease in obese children

Researchers at the Universitat de València, Universitat Politècnica de València (UPV), Doctor Peset University Hospital and the Institute of Agrochemistry and Food Technology of CSIC have designed and tested the effectiveness of a new apple snack impregnated with tangerine juice that reduces the risk of cardiovascular disease in obese children and improves their physiological well-being.

23 Sep 2013

Exposing young girls to ionizing radiation can raise risk of breast cancer later in life

Exposing young women and girls under the age of 20 to ionizing radiation can substantially raise the risk of their developing breast cancer later in life. Scientists may now know why. A collaborative study, in which Berkeley Lab researchers played a pivotal role, points to increased stem cell self-renewal and subsequent mammary stem cell enrichment as the culprits.

12 Sep 2013

New research explains how DNA strands repair themselves

Researchers have discovered the details of how cells repair breaks in both strands of their DNA, a potentially devastating kind of DNA damage.

12 Sep 2013

Astrazeneca Licenses Merck's Cancer Candidate MK-1775

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11 Sep 2013

University of Alberta researchers study how DNA repair improves cancer therapies

Medical researchers at the University of Alberta have made a basic science discovery that advances the understanding of how DNA repairs itself. When DNA becomes too damaged it ultimately leads to cancer.

11 Sep 2013

Scientists unravel how DNA damage may trigger lupus erythematosus

Summer, sun and the sea - a dream vacation for most - can turn sour for those affected by lupus erythematosus. For them, absorption of the UV-light component in sunlight may cause florid inflammation and redness of the skin. Scientists of the University Hospital Bonn, Germany have now discovered which signaling pathway of the innate immune system promotes autoimmune symptoms following sun-induced DNA damage.

30 Aug 2013

Institut Curie's Emmanuel Barillot receives Agilent Thought Leader Award

Agilent Technologies Inc. today announced that Dr. Emmanuel Barillot, director of Bioinformatics and Systems IT at the Institut Curie in Paris, has received an Agilent Thought Leader Award in recognition of his pioneering development of user-friendly, Web-based bioinformatics tools for systems toxicology.

28 Aug 2013

URI professor studies rare hereditary disorder Fanconi anemia in children

When 2-year-old Logan Stevenson served as best man at his parents' wedding just days before he died of a rare genetic disorder, it drew international attention to a disease about which few people had ever heard. Hearing about Logan's story added another level of urgency to the research being conducted by University of Rhode Island Associate Professor Niall Howlett.

28 Aug 2013

Novel Parkinson’S Target Uncovered

Researchers from Johns Hopkins and the National Cancer Institute (NCI) highlighted a novel mechanism underlying Parkinson's disease while simultaneously putting to rest a previously held theory regarding progression of the disorder. They also identified a compound that alleviates the disease's symptoms in mice.

27 Aug 2013

Researchers identify compound that eases symptoms of Parkinson's disease

Researchers at Johns Hopkins and elsewhere have brought new clarity to the picture of what goes awry in the brain during Parkinson's disease and identified a compound that eases the disease's symptoms in mice.

26 Aug 2013

Seven researchers to receive grants from ASTRO to advance radiation oncology research

The American Society for Radiation Oncology (ASTRO) has selected seven (7) leading researchers who will receive a total of $675,000 in awards and grants to advance radiation oncology research.

23 Aug 2013

MC1R mutation responsible for red hair phenotype also promotes cancer-causing pathway

A person's skin pigment, which determines hair color and skin tone, is influenced by the melanocortin-1 (MC1R) gene receptor. For the population's one to two percent of redheads, a mutation in MC1R accounts for their red hair color and typical light skin.

23 Aug 2013

Medical investigators discover new aspect of gene-splicing process that produces mRNA

A rare, small RNA turns a gene-splicing machine into a switch that controls the expression of hundreds of human genes. Howard Hughes Medical Institute Investigator and professor of Biochemistry Gideon Dreyfuss, PhD, and his team from the Perelman School of Medicine at the University of Pennsylvania, discovered an entirely new aspect of the gene-splicing process that produces messenger RNA (mRNA).

22 Aug 2013

Study: Mother's mitochondrial DNA seems to influence our own aging

As we age, our cells change and become damaged. Now, researchers at Karolinska Institutet and the Max Planck Institute for Biology of Aging have shown that aging is determined not only by the accumulation of changes during our lifetime but also by the genes we acquire from our mothers.

22 Aug 2013

Michigan researchers use TACC supercomputers to understand DNA bending, repair mechanisms

The biological information that makes us unique is encoded in our DNA. DNA damage is a natural biological occurrence that happens every time cells divide and multiply. External factors such as overexposure to sunlight can also damage DNA.

17 Aug 2013

Scientists present novel method to visualize how nuclear protein mobility changes following DNA damage

Understanding the cellular response to DNA strand breaks is crucial to decipher the mechanisms maintaining the integrity of our genome. In eukaryotic cells, the molecular events triggered by DNA damage are strongly influenced by the local chromatin environment surrounding the lesion. The ensuing DNA repair process, in turn, impacts on chromatin structure. In order to understand how these two fundamental processes are mutually connected, both chromatin rearrangements induced by DNA damage as well as DNA repair activity have to be visualized in living cells.

12 Aug 2013

DNA Damage News and Research

Researcher receives grant to explore HER2-positive breast tumor susceptibility to PARP inhibitors

Genomic instability in CFS is associated with less favorable outcome in patients with CaP

TSRI scientists discover process by which special immune cells in skin help heal wounds

'Jekyll-and-Hyde' protein could be potent target for developing new cancer drugs

Apple impregnated with tangerine juice reduces risk of cardiovascular disease in obese children

Exposing young girls to ionizing radiation can raise risk of breast cancer later in life

New research explains how DNA strands repair themselves

Astrazeneca Licenses Merck's Cancer Candidate MK-1775

University of Alberta researchers study how DNA repair improves cancer therapies

Scientists unravel how DNA damage may trigger lupus erythematosus

Institut Curie's Emmanuel Barillot receives Agilent Thought Leader Award

URI professor studies rare hereditary disorder Fanconi anemia in children

Novel Parkinson’S Target Uncovered

Researchers identify compound that eases symptoms of Parkinson's disease

Seven researchers to receive grants from ASTRO to advance radiation oncology research

MC1R mutation responsible for red hair phenotype also promotes cancer-causing pathway

Medical investigators discover new aspect of gene-splicing process that produces mRNA

Study: Mother's mitochondrial DNA seems to influence our own aging

Michigan researchers use TACC supercomputers to understand DNA bending, repair mechanisms

Scientists present novel method to visualize how nuclear protein mobility changes following DNA damage

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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