Genes News and Research

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Scientists elucidate surprising dual function of ceramide synthase

Scientists at the University of Bonn have clarified a surprising dual function of ceramide synthase. The enzyme not only catalyzes a central step of the production of vital lipids. It also has the ability to turn genes involved in lipid metabolism on or off. The study is being published in the renowned journal Cell Reports.

24 Jan 2018

Genome analysis reveals leprosy's origin and drug resistance

Leprosy is an infectious disease with gruesome symptoms. It damages the skin, peripheral nerves, the upper respiratory tract, and the eyes.

24 Jan 2018

BIST researchers develop new retinal prosthesis to address visual degeneration

A healthy retina contains photoreceptor cells that convert light changes into nerve impulses, which are then carried along the optic nerve to the brain, where they are decoded into images. Diseases such as retinitis pigmentosa cause the photoreceptor cells to stop functioning, while the rest of the eye remains healthy.

24 Jan 2018

Researchers use epigenetic signatures to advance diagnosis for neurodevelopmental disorders

Greenwood Genetic Center researchers in collaboration with scientists from Canada have identified unique epigenetic signatures for nine neurodevelopmental disorders lending to a better method of diagnosis for disorders with much clinical overlap.

23 Jan 2018

Personality changes occur early on during development of Alzheimer's disease, research finds

A key feature of Alzheimer's disease is memory loss and losing one's ability to think and make decisions (also called "cognitive ability"). Those changes can begin slowly, during a phase called "mild cognitive impairment" (or MCI). A variety of diseases can cause MCI, but the most common is Alzheimer's disease.

23 Jan 2018

Experts issue updated guidelines for molecular diagnostic testing of patients with lung cancer

A panel of leading experts in molecular pathology has issued new recommendations and updates to guidelines for molecular diagnostic testing of patients with lung cancer.

23 Jan 2018

Researchers unravel function of protein ‘smallish’

During the development of an embryo, every single cell needs to know who it is, where it is, and what it has to do. Important is the polarity of the cell: Where is the top, where is the bottom, where are front and back? Only when the cell is polarized in the right way can it change the shape in exactly the way which is needed to form a certain structure or organ.

23 Jan 2018

Scientists identify molecular key that opens up compacted genome

News article describing the recent discovery of pax7, a protein which opens up compacted DNA for access by transcription factors.

23 Jan 2018

Scientists take tissue-engineering approach to improve healing related to skeletal system

"Take a knee." "On bended knee." A "knee-slapper." "The bee's knees." The knee certainly carries a lot of weight in the English language, just as it does in the body. As the largest and one of the most complicated joints, the knee is also one of the most easily injured.

23 Jan 2018

Study identifies genes involved in latent asymptomatic state of breast cancer metastases

The time needed for breast cancer metastases (secondary lesions caused by cells that have escaped from the original tumor) to develop varies between patients, and little is known about the mechanisms that govern latency (the dormant state of cells that have already spread through the body).

23 Jan 2018

JAX researcher receives grant for retinal disease research

The National Eye Institute has awarded Jackson Laboratory Professor Juergen Naggert, Ph.D., a five-year grant totaling $2,187,500 to study genetically controlled breaks in an eye structure known as the external limiting membrane, which could hold the key to understanding and treating enhanced S-cone syndrome and other diseases of the retina.

22 Jan 2018

New genomic tools provide better understanding of the human immune system

When the body is under attack from pathogens, the immune system marshals a diverse collection of immune cells to work together in a tightly orchestrated process and defend the host against the intruders.

22 Jan 2018

Researchers develop single blood test that screens for 8 cancer types

Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer.

19 Jan 2018

Researchers describe atom-by-atom changes in ALS-linked protein

For the first time, researchers have described atom-by-atom changes in a family of proteins linked to amyotrophic lateral sclerosis (ALS), a group of brain disorders known as frontotemporal dementia and degenerative diseases of muscle and bone.

19 Jan 2018

Beneficial bacteria on the skin of mice promotes immunity and accelerates wound healing

Beneficial bacteria on the skin of lab mice work with the animals' immune systems to defend against disease-causing microbes and accelerate wound healing, according to new research from scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

19 Jan 2018

Researchers discover potential target genes to halt thyroid cancer progression

Thyroid cancer is a disease with good cure rates in most cases. In 5% of patients, however, the tumor becomes refractory to the available therapies and may spread all over the body, causing death.

19 Jan 2018

Scientists methodically identify genes related to blood feeding and non-biting mosquitoes

Researchers have taken the first step on a path that eventually could result in female mosquitoes that no longer bite and spread diseases.

19 Jan 2018

Researchers develop new mathematical tool to solve genetics challenge

Researchers developed a new mathematical tool to validate and improve methods used by medical professionals to interpret results from clinical genetic tests. The work was published this month in Genetics in Medicine.

19 Jan 2018

Study reveals key role of macrophages in systemic sclerosis

A new international study has made an important discovery about the key role of macrophages, a type of immune cell, in systemic sclerosis (SSc), a chronic autoimmune disease which currently has no cure.

19 Jan 2018

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute, led by Dr. Àlex Vaquero, have proposed a new regulation mechanism of the NF-κB pathway, which is associated with accelerated cellular aging, based on the analysis of the function of the SirT6 protein.

19 Jan 2018

Genes News and Research

Scientists elucidate surprising dual function of ceramide synthase

Genome analysis reveals leprosy's origin and drug resistance

BIST researchers develop new retinal prosthesis to address visual degeneration

Researchers use epigenetic signatures to advance diagnosis for neurodevelopmental disorders

Personality changes occur early on during development of Alzheimer's disease, research finds

Experts issue updated guidelines for molecular diagnostic testing of patients with lung cancer

Researchers unravel function of protein ‘smallish’

Scientists identify molecular key that opens up compacted genome

Scientists take tissue-engineering approach to improve healing related to skeletal system

Study identifies genes involved in latent asymptomatic state of breast cancer metastases

JAX researcher receives grant for retinal disease research

New genomic tools provide better understanding of the human immune system

Researchers develop single blood test that screens for 8 cancer types

Researchers describe atom-by-atom changes in ALS-linked protein

Beneficial bacteria on the skin of mice promotes immunity and accelerates wound healing

Researchers discover potential target genes to halt thyroid cancer progression

Scientists methodically identify genes related to blood feeding and non-biting mosquitoes

Researchers develop new mathematical tool to solve genetics challenge

Study reveals key role of macrophages in systemic sclerosis

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

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