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Researchers discover potential regulator essential for killer T cells to reside in tumors

Researchers report the discovery that a protein called "Runx3" programs killer T cells to establish residence in tumors and infection sites.

11 Dec 2017

Researchers generate 3D cell cultures to investigate mechanisms of drug resistance in breast cancer

An international research team headed by the University of Bern and the Netherlands Cancer Institute has developed 3D cell cultures in which genes can be specifically modified. They allow the study of genes that may cause therapy resistance in breast cancer.

11 Dec 2017

St. Jude gene therapy offers hope for infants with 'bubble boy' disease

Early evidence suggests that gene therapy developed at St. Jude Children's Research Hospital will lead to broad protection for infants with the devastating immune disorder X-linked severe combined immunodeficiency disorder.

11 Dec 2017

Bi-annual MRI beats mammograms in detecting breast cancer among women with genetic risk

Intensive surveillance including a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) exam every six months was far more effective in detecting breast cancer in younger women with a high-risk genetic profile than an annual mammogram, according to a research team based at the University of Chicago Medicine and the University of Washington, Seattle.

11 Dec 2017

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

Researchers have discovered a mechanism of resistance to checkpoint inhibitors and how to reverse it. The biomarker results from the IMvigor210 study are reported at the ESMO Immuno Oncology Congress 2017.

8 Dec 2017

PARP inhibitor can be new treatment option for patients with metastatic breast cancer, BRCA mutations

In a randomized, Phase III trial led by researchers at The University of Texas MD Anderson Cancer Center, the PARP inhibitor talazoparib extended progression-free survival (PFS) and improved quality-of-life measures over available chemotherapies for patients with metastatic HER2-negative breast cancer and mutations in the BRCA1/2 genes.

8 Dec 2017

Scientists discover how axons in developing visual system stabilize their connections

Scientists at Tokyo Tech have made an important discovery concerning the development of layer-specific axonal connections in the developing visual system of Drosophila flies.

8 Dec 2017

Family members who do not carry inherited mutation have higher risk of melanoma

In families who carry certain inherited mutations that increase the risk for melanoma, members who do not carry the mutation also have an increased risk of melanoma, a study from Karolinska Institutet published in Genetics in Medicine reports.

8 Dec 2017

Parental lifespan genes could pave way for new therapeutic targets to prolong life

A large-scale international study led by the University of Exeter Medical School has discovered new genes linked to parents' lifespan - which could one day be targeted to help prolong human life.

8 Dec 2017

Researchers identify challenges to understanding and classifying mental disorders

Mental illnesses, such as major depression, bipolar disorder and post-traumatic stress disorder, affect nearly 1 in 5 adults in the United States, according to the National Alliance on Mental Illness. Many aspects of these illnesses remain something of a mystery, despite the progress made in understanding them by researchers studying these disorders in the last half century.

7 Dec 2017

Large-scale study expands number of genetic markers linked to exceptional longevity

A new large-scale international study expands the number of genetic markers now known to be associated with exceptional longevity.

7 Dec 2017

Common fungus has significant impact on mosquitoes' ability to transmit dengue virus

A species of fungus that lives in the gut of some Aedes aegypti mosquitoes increases the ability of dengue virus to survive in the insects, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.

7 Dec 2017

Researchers discover how unusually long strands of RNA work in skin cells

Researchers from Case Western Reserve University School of Medicine have discovered how unusually long pieces of RNA work in skin cells.

7 Dec 2017

Higher educational attainment associated with lower risk of Alzheimer's disease

Using genetic information, researchers at Karolinska Institutet in Sweden provide new evidence that higher educational attainment is strongly associated with a lower risk of Alzheimer's disease. The study is published in The BMJ.

7 Dec 2017

Researchers establish function of long RNA strands in skin development and disease

Researchers have found out how long pieces of RNA called “long non-coding RNAs” (LncRNAs) work in skin cells to modulate connective tissue proteins such as collagen, potentially laying the foundations for new skin repair therapies.

7 Dec 2017

TUM scientists build virus-sized structures using DNA origami technology

It is the double strands of our genes that make them so strong. Using a technique known as DNA origami, biophysicist Hendrik Dietz has been building nanometer-scale objects for several years at the Technical University of Munich.

7 Dec 2017

Brazilian researchers identify genes linked to melanoma progression

When researchers at the University of São Paulo in Brazil treated human melanoma cell lines with a synthetic compound similar to curcumin, one of the pigments that give turmeric its orange color, they identified genes with altered expression in potentially invasive tumors and malignant cells resistant to chemotherapy.

6 Dec 2017

Genes News and Research

Researchers discover potential regulator essential for killer T cells to reside in tumors

Researchers generate 3D cell cultures to investigate mechanisms of drug resistance in breast cancer

St. Jude gene therapy offers hope for infants with 'bubble boy' disease

Bi-annual MRI beats mammograms in detecting breast cancer among women with genetic risk

Study finds mechanism of resistance to checkpoint inhibitors and way to reverse it

PARP inhibitor can be new treatment option for patients with metastatic breast cancer, BRCA mutations

Scientists discover how axons in developing visual system stabilize their connections

Family members who do not carry inherited mutation have higher risk of melanoma

Parental lifespan genes could pave way for new therapeutic targets to prolong life

Researchers identify challenges to understanding and classifying mental disorders

Large-scale study expands number of genetic markers linked to exceptional longevity

Common fungus has significant impact on mosquitoes' ability to transmit dengue virus

Researchers discover how unusually long strands of RNA work in skin cells

Higher educational attainment associated with lower risk of Alzheimer's disease

Researchers establish function of long RNA strands in skin development and disease

TUM scientists build virus-sized structures using DNA origami technology

Brazilian researchers identify genes linked to melanoma progression

CLOCK gene plays key role in regulating many genes important to brain evolution

Study shows how interplay between two key enzymes promotes brain tumor growth

Researchers identify risk factor for drug-induced skin disease in diabetic patients

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