Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

New method can help detect melanoma cells in skin tumors

Melanoma is the least common but one of the most deadly skin cancers. It accounts for only about one percent of all cases globally, but the majority of skin cancer deaths.

30 Sep 2019

Pioneering melanoma test to be made available within two years

Scientists have developed a pioneering new test that can more accurately predict whether melanoma, a type of skin cancer, is likely to return.

27 Sep 2019

High-dose radiation effective for men whose prostate cancer has spread, trial shows

A randomized clinical trial of targeted, high-dose radiation for men with oligometastatic prostate cancer has shown the treatment to be an effective and safe option for patients who wish to delay hormone-suppression therapy.

26 Sep 2019

UCLA researchers identify new drug delivery pathway to stop tumor growth

Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new drug delivery pathway that may help stop tumor growth and keep cancer from coming back in mice.

25 Sep 2019

Johns Hopkins researchers link a gene to melanoma growth and spread

Using a small noncoding RNA, microRNA 211, and tools that track the stability and decay of the protein-coding and noncoding RNAs in lab-grown melanoma cells, a team led by a Johns Hopkins Kimmel Cancer Center researcher identified highly unstable RNA molecules in human melanomas, including a novel miR-211 target gene DUSP3.

From Johns Hopkins Medicine 25 Sep 2019

U-M and Karmanos receive NCI grant to find new solutions for prostate cancer

Michigan's two elite cancer programs are joining forces to find new solutions for prostate cancer. The University of Michigan Rogel Cancer and the Barbara Ann Karmanos Cancer Institute have received a prestigious $9.2 million grant from the National Cancer Institute.

23 Sep 2019

Researchers develop new technology to study cell nanomechanics

Researchers at Singapore-MIT Alliance for Research and Technology and MIT's Laser Biomedical Research Center have developed a new way to study cells, paving the way for a better understanding of how cancers spread and become killers.

20 Sep 2019

Mitochondrial fission factor could represent a promising target for cancer therapy

Researchers at The Wistar Institute have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target. They also found that expression of MFF is regulated by Myc, a ubiquitous mediator of cell proliferation that contributes to development of many cancer types.

20 Sep 2019

Research: Metformin may be effective in treating breast cancer that lacks Nischarin protein

Research conducted by Suresh Alahari, PhD, Professor of Biochemistry and Genetics at LSU Health New Orleans School of Medicine, has found that metformin, a commonly prescribed drug for Type 2 Diabetes, may be effective in treating cancers that lack a protein called Nischarin.

20 Sep 2019

NMDAR receptor is responsible for breast-to-brain metastases, shows study

In 2018, breast cancer was the most common cancer in women worldwide, accounting for about a quarter of all reported cancers. One of the biggest problems with any type of cancer is metastasis; and when breast cancer metastasizes, the brain is a common destination.

19 Sep 2019

Compound could play a novel role in halting spread of pancreatic cancer

In early test tube and mouse studies, investigators at Johns Hopkins Medicine and the Johns Hopkins Kimmel Cancer Center have found that nonmuscle myosin IIC (MYH14), a protein activated in response to mechanical stress, helps promote metastatic behavior in pancreatic cancer cells, and that the compound 4-hydroxyacetophenone (4-HAP), known to stiffen myosin IIC-containing cells, can send it into overdrive, overwhelming the ability of cells to invade nearby tissue.

18 Sep 2019

Anti-cancer effects of lycopene in tomatoes canceled out by iron-rich foods

Tomatoes have proven cancer-fighting properties, but new research suggests that eating them with iron-rich meats can destroy this effect.

18 Sep 2019

Clinical trial finds no difference in pain response between SBRT and cEBRT for patients with spinal metastases

A Phase III, NRG Oncology clinical trial that compared radiosurgery or stereotactic body radiotherapy to the conventional radiotherapy for patients with spinal metastases indicated that there was no statistically significant difference between the treatments for pain response, adverse events, FACT-G, BPI, and EQ-5D scores.

17 Sep 2019

New biomarkers help predict response to treatment in common brain tumor

Many scientists have noted that there is a link between inflammation or the immune response, and patient survival. One such possible relationship is the association of blood markers and the prognosis in the brain tumor called medulloblastoma.

16 Sep 2019

Study quantifies energetic costs of cancer cells during metastasis

New research from a group of Vanderbilt biomedical engineers reveals that while cancer cells move quickly in metastasis, they're rather lazy in which paths they choose.

15 Sep 2019

Study reveals how breast cancer uses exosomes to metastasize to the brain

Metastasizing breast cancers typically seek out the bones, lung, and brain. Brain metastases are especially dangerous; many women survive for less than a year after diagnosis. How is the cancer able to get past the blood brain barrier? And can it be blocked?

13 Sep 2019

Cell adhesion protein promotes metastasis in breast cancer, study reveals

Researchers at the Johns Hopkins Kimmel Cancer Center discovered that a cell adhesion protein, E-cadherin, allows breast cancer cells to survive as they travel through the body and form new tumors, a process termed metastasis.

From Johns Hopkins Medicine 11 Sep 2019

Nerve cells aid in the spread of pancreatic cancer, study reveals

A couple of molecules that nerve cells use to grow during development could help explain why the most common pancreatic cancers are so difficult to contain and for patients to survive, a new study led by Johns Hopkins Kimmel Cancer Center researchers suggests.

30 Aug 2019

Cancer cells ‘corrupt’ their healthy neighbors to support tumor growth

The healthy cells immediately surrounding a tumor become more stem cell-like and support cancer growth, reveals a new study published in Nature.

From The Francis Crick Institute 29 Aug 2019

Scientists identify PoEMs that promote breast cancer metastasis

When breast cancer cells spread through the body, they do so mainly through the lymph system that normally removes excess fluid and waste products from our tissues.

28 Aug 2019