Signaling Pathway News and Research

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Research findings on sweat glands have potential to improve methods for culturing skin grafts

As early humans shed the hairy coats of their closest evolutionary ancestors, they also gained a distinct feature that would prove critical to their success: a type of sweat gland that allows the body to cool down quickly. Those tiny glands are enormously useful, allowing us to live in a wide variety of climates, and enabling us to run long distances.

4 Jan 2017

Physical inactivity in obese mice linked to dopamine signaling defects

Starting a regular program at the gym is a common New Year's resolution, but it's one that most people are unable to stick with for very long.

30 Dec 2016

Phase I study of selumetinib drug shows partial response in pediatric neural tumors

In an early-phase clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 (NF1) and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage.

29 Dec 2016

Generative AAE can be radically new way to discover drugs on demand

Scientists at the Pharmaceutical Artificial Intelligence group of Insilico Medicine, Inc, today announced the publication of a seminal paper demonstrating the application of generative adversarial autoencoders (AAEs) to generating new molecular fingerprints on demand.

22 Dec 2016

RAGE regulates key signaling pathway that promotes acute and chronic inflammation

Researchers have shown that Receptor for Advanced Glycation End Products helps to regulate a key signaling pathway known to promote both acute and chronic inflammation.

21 Dec 2016

Research findings reveal new powerful role of sunlight on immunity

Sunlight allows us to make vitamin D, credited with healthier living, but a surprise research finding could reveal another powerful benefit of getting some sun.

20 Dec 2016

Sirt1 plays key role in regenerating glial progenitor cells after hypoxia-induced brain injury in preemies

Developing brains in newborns have a sizable pool of a certain type of immature progenitor cell that can be expanded and induced to replace cells lost to brain injury.

19 Dec 2016

Researchers use worms as model system to study how gut microbiome influences disease

The billions of microorganisms living within the human digestive tract appear to play a significant role in health and disease, notably metabolic syndrome, autoimmune disorders and diabetes - but how these organisms do so is not well understood.

17 Dec 2016

Scientists discover how COPD patients' lungs lose ability to repair damages

In chronic obstructive pulmonary disease (COPD), the patients' lungs lose their ability to repair damages on their own.

16 Dec 2016

Signaling pathway in fat cells may provide key to better treatments for obesity, Penn research finds

A signaling pathway in fat cells may one day provide the key to better treatments for obesity, according to new research by scientists in the Perelman School of Medicine at the University of Pennsylvania.

6 Dec 2016

Reseachers identify cellular ‘off’ switch for inflammatory immune response in asthma attacks

Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular "off" switch for the inflammatory immune response that contributes to lung-constricting asthma attacks.

2 Dec 2016

Researchers uncover new prognostic marker and possible therapeutic target for Ewing's sarcoma

Researchers of the Sarcoma research group of the Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, have first described the methylation profile of Ewing's sarcoma, a cancer of bone and soft tissues that mainly affects children and teenagers.

1 Dec 2016

Pro-growth cancer signaling pathway could light up new avenues of treatments for solid tumors

Researchers from the University of Wisconsin School of Medicine and Public Health and Carbone Cancer Center have better defined a pro-growth signaling pathway common to many cancers that, when blocked, kills cancer cells but leaves healthy cells comparatively unharmed.

23 Nov 2016

Blocking key nutrient uptake may be effective way of treating triple negative breast cancer

Cancer rewires the metabolism of tumor cells, converting them into lean, mean, replicating machines.

21 Nov 2016

Researchers discover molecular pathway that plays major role in maintaining normal kidney function

Boston University researchers, in collaboration with Centers for Therapeutic Innovation at Pfizer Inc., have discovered a novel molecular pathway needed to regulate kidney podocytes--special octopus-like cells that are critical in maintaining normal kidney function.

17 Nov 2016

UAB researchers show how aging and excess dietary fat lead to heart failure

In mouse experiments, University of Alabama at Birmingham researchers have shown how aging and excess dietary fat create signals that lead to heart failure after a heart attack.

17 Nov 2016

Researchers discover signaling pathway that can stop brain tumor formation in animal models

A research team at the Krembil Research Institute has discovered that a signaling pathway which controls blood vessel development in the brain has the ability to stop brain tumor formation in animal models of medulloblastoma, the most common malignant brain tumor diagnosed in children.

8 Nov 2016

Researchers discover Hedgehog signaling pathway is key to formation of gastrointestinal stromal tumors

Researchers at University of California San Diego School of Medicine and Mayo Clinic provide the first evidence that the Hedgehog signaling pathway is central to the formation of gastrointestinal stromal tumors (GIST), which are frequently driven by the KIT oncogene.

1 Nov 2016

Calcium triggers virulence switch from acute to chronic lung infections

The bacterium Pseudomonas aeruginosa is a life-threatening pathogen in hospitals. About ten percent of all nosocomial infections, in particular pneumonia, are caused by this pathogen.

24 Oct 2016

Researchers discover new therapeutic target for controlling fatal allergic reactions

Researchers in France have identified a molecular motor that controls the release of inflammatory factors that cause severe and fatal allergic reactions.