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Novel drug combination could enhance immunotherapy responses in patients with lung cancer

Johns Hopkins Kimmel Cancer Center researchers and colleagues have identified a novel drug combination therapy that could prime nonsmall cell lung cancers to respond better to immunotherapy.

30 Nov 2017

NIH grant supports research on cellular mechanisms governing longevity

The MDI Biological Laboratory has announced that Aric Rogers, Ph.D., has received a grant of $455,000 over two years from the National Institute on Aging, one of the institutes of the National Institutes of Health, for research on the cellular mechanisms governing longevity.

30 Nov 2017

Scientists use computer analysis to complete antibody blueprint

Antibodies defend our bodies against intruders. These molecules consist of proteins with attached sugars. However, the blueprint directing the processing of these sugars on the protein was not well understood until now.

30 Nov 2017

Researchers create first semi-synthetic organism that can store and use unnatural genetic information

Researchers from The Scripps Research Institute (TSRI) have designed a bacterium that incorporates two unnatural bases, called X and Y, into genes, in addition to the four natural DNA bases − G, C, A and T − that usually code for proteins.

30 Nov 2017

Altering genetic mutation could enhance FluMist vaccine’s protective effect

Researchers at Johns Hopkins Bloomberg School of Public Health have discovered a genetic mutation in the FluMist intranasal flu vaccine that has the potential to be altered to enhance the vaccine's protective effect.

30 Nov 2017

Researchers discover rare genetic variant that offers protection against Alzheimer's disease

Research published Wednesday in Genome Medicine details a novel and promising approach in the effort to treat Alzheimer's disease.

30 Nov 2017

UT Southwestern researchers develop improved gene-editing technique to correct DMD mutations

Regenerative medicine researchers at UT Southwestern Medical Center developed an improved and simplified gene-editing technique using CRISPR/Cas9 tools to correct a common mutation that causes Duchenne muscular dystrophy.

30 Nov 2017

Researchers unlock genetic processes underlying cancer

For many, breast cancer is more than just a disease – it's personal. One in eight women will be diagnosed with breast cancer at some point in their lives. But through new discoveries at the genetic level, the personal nature of cancer will eventually be what helps to beat it.

29 Nov 2017

New genetic study of mosquitoes demonstrates movement of insecticide resistance across Africa

The largest ever genetic study of mosquitoes reveals the movement of insecticide resistance between different regions of Africa and finds several rapidly evolving insecticide resistance genes. Reported today) in Nature, this genetic resource will be used to develop new tools for monitoring resistance and managing insecticide use, and for designing novel control methods.

29 Nov 2017

Easy-to-use omics toolkit sets the stage for new era of biology and precision medicine

Most complex diseases, such as obesity, longevity, and diabetes, are largely influenced by genetic factors. But at the same time, they are also modulated by environmental stimuli, such as diet and physical activity.

29 Nov 2017

Specific gene expression patterns could be key to younger looking skin

Some individuals' skin appears more youthful than their chronologic age. Although many people try to achieve this with creams, lotions, injections, and surgeries, new research published in the Journal of the American Academy of Dermatology indicates that increased expression of certain genes may be the key to intrinsically younger looking - and younger behaving - skin.

29 Nov 2017

UT Southwestern researchers take early step toward personalized care for breast cancer

UT Southwestern Medical Center researchers have developed a method to map protein changes that occur in different subtypes of breast cancer cells in response to DNA damage from a new class of chemotherapy drugs.

29 Nov 2017

Study provides new insights into mechanisms contributing to ovarian cancer

Ovarian cancer is the most lethal gynecologic malignancy in the United States, resulting in an estimated 14,100 deaths and 22,500 new cases in 2017 alone. This high mortality is primarily caused by resistance to therapy and the diagnosis of ovarian cancer after it has already metastasized, which occurs in approximately 80 percent of patients.

29 Nov 2017

HCI researchers observe how breast cancer tumors evolve over time

A new study by researchers at Huntsman Cancer Institute at the University of Utah observed how breast cancer tumors evolve over time and demonstrated how changes within tumors may contribute to the process by which cancers no longer respond to treatment.

29 Nov 2017

FSU researchers solve puzzle posed by family of rare premature aging disorders

New research from Florida State University is beginning to piece together the stubborn puzzle posed by a family of rare and debilitating premature aging disorders.

28 Nov 2017

New molecular taxonomy may lead to precision-medicine treatments for hair disorders

Two decades ago, oncologists realized that molecular biologists could see medically important differences between tumors that looked identical to pathologists.

28 Nov 2017

Mothers of teenagers with ASD report higher levels of negative psychological symptoms

Anyone who has ever survived being a teenager should be well aware that parenting a teenager can be no easy feat. But factor in a diagnosis of autism spectrum disorder (ASD) or intellectual disability (ID), and you'll likely have the recipe for a unique set of challenges to the entire family unit.

28 Nov 2017

Johns Hopkins researchers crack key part of mystery surrounding proteins

What makes the body of a person or any other organism work can, for the most part, be summed up in a word: proteins.

28 Nov 2017

Treatment with endogenous protein can heal scarring in the lungs

The endogenous protein RAGE, which has usually been negatively associated with chronic inflammation and diabetic complications, plays a major role in the repair of DNA damage - and also appears to heal tissue damaged as a result of accelerated cell senescence.

27 Nov 2017

People with genetic predisposition to later puberty have lower bone mineral density

People whose genetic makeup triggers a later-than-average start to puberty have lower bone mineral density, especially in their lower spine. Because adolescence is a critical period for accruing bone, this effect may increase a person's risk of osteoporosis and bone fractures later in life.

27 Nov 2017

Genes News and Research

Novel drug combination could enhance immunotherapy responses in patients with lung cancer

NIH grant supports research on cellular mechanisms governing longevity

Scientists use computer analysis to complete antibody blueprint

Researchers create first semi-synthetic organism that can store and use unnatural genetic information

Altering genetic mutation could enhance FluMist vaccine’s protective effect

Researchers discover rare genetic variant that offers protection against Alzheimer's disease

UT Southwestern researchers develop improved gene-editing technique to correct DMD mutations

Researchers unlock genetic processes underlying cancer

New genetic study of mosquitoes demonstrates movement of insecticide resistance across Africa

Easy-to-use omics toolkit sets the stage for new era of biology and precision medicine

Specific gene expression patterns could be key to younger looking skin

UT Southwestern researchers take early step toward personalized care for breast cancer

Study provides new insights into mechanisms contributing to ovarian cancer

HCI researchers observe how breast cancer tumors evolve over time

FSU researchers solve puzzle posed by family of rare premature aging disorders

New molecular taxonomy may lead to precision-medicine treatments for hair disorders

Mothers of teenagers with ASD report higher levels of negative psychological symptoms

Johns Hopkins researchers crack key part of mystery surrounding proteins

Treatment with endogenous protein can heal scarring in the lungs

People with genetic predisposition to later puberty have lower bone mineral density

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