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SARS-CoV-2 genome shows mutation hotspots and type-specific distribution

Now, a new study published on the preprint server bioRxiv reports on a large scale analysis of SARS-CoV-2 genomes and reveals a clonal geo-distribution and rich genetic variations.

5 May 2020

COVID-19 infection risk and outcomes explained by the cell receptor genetic variability

Genetic variants in the angiotensin‐converting enzyme 2 (ACE2) receptor, utilized by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) for cell entry, are predicted to either encourage or inhibit interaction with viral proteins and subsequently contribute to genetic risk in coronavirus disease (COVID-19). This is the key finding of a new study available on the preprint server bioRxiv*.

5 May 2020

New therapeutic possibilities for treating intellectual disability in Down syndrome

A team of researchers has studied the neural basis of intellectual disability in mice with Down syndrome and has discovered that the neural networks of brain circuits relevant to memory and learning are over-activated and that the connectivity of these circuits is poor.

5 May 2020

Study explores maternal infection and its role in neurodevelopmental disorders

The immune responses of a female mouse before pregnancy can predict how likely her offspring are to have behavioral deficits if the immune system is activated during pregnancy, according to researchers from the Center for Neuroscience at the University of California, Davis.

5 May 2020

Indian physicians’ petition puts focus on race risks in the wake of COVID-19

A group of leading, ethnic Indian physicians has petitioned Britain's National Health Service (NHS) to formally include ethnicity as a COVID-19 infection risk factor for healthcare workers in the UK.

5 May 2020

Researchers discover new gene involved in regulating the body's cholesterol

Precision medicine has the potential to tailor treatments to a patient's unique genetic sequence. But achieving this precision -- or developing new drugs -- requires knowing which genes are involved in disease.

4 May 2020

COVID-19 progression linked to B cell activation

The disease course of COVID-19 is diverse, ranging from asymptomatic to fatal respiratory failure. Scientists have been working to uncover the immunological reasons behind this heterogeneity. A recent study on B cells, published on the preprint server medRxiv in April 2020, shows that extrafollicular B cells could be a marker of severe infection in the early stages, predicting the need for earlier immunomodulatory therapy.

4 May 2020

Human endemic coronavirus reinfection possible after recovery

The novel coronavirus started spreading in December 2019, and since then, it has rippled across the globe, affecting 187 countries and territories, and infecting more than 3.18 million people. However, the behavior and mechanism of the virus, including whether it provides adaptive immunity, is still unclear. There have been reports of reinfection out of South Korea and Japan

4 May 2020

New technology enables visualization of small structures inside whole cells and tissues

Since Robert Hooke's first description of a cell in Micrographia 350 years ago, microscopy has played an important role in understanding the rules of life.

4 May 2020

Rice scientist wins federal grant for eye research

A Rice University researcher has won a prestigious federal grant to study how a recently identified protein in the cornea aids development, homeostasis and wound healing in the eye.

4 May 2020

ASU team identifies new, unique SARS-CoV-2 mutation

As the coronavirus pandemic has swept across the U.S., in addition to tracking the number of COVID daily cases, there is a worldwide scientific community engaged in tracking the SARS-CoV-2 virus itself.

4 May 2020

Wyss Institute and Cytosurge collaborate to improve CRISPR multiplexing

Today, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Cytosurge AG, a company manufacturing unique high-precision nanotechnology instruments, announced that they will collaboratively investigate CRISPR-based approaches to more effectively introduce multiple edits into the genome of single cells, while minimizing CRISPR-related toxicity.

4 May 2020

Scientists develop CRISPR-based test for SARS-CoV-2

Now, a team of scientists at the University of California Santa Barbara has developed a low-cost, rapid, and high-tech test that can detect SARS-CoV-2 effectively. They have developed a CRISPR-based test that is sensitive and effective as traditional tests.

4 May 2020

Researchers discover hidden symmetry in chemical kinetic equations

Rice University researchers have discovered a hidden symmetry in the chemical kinetic equations scientists have long used to model and study many of the chemical processes essential for life.

4 May 2020

Scientists develop new way to deliver molecules that target specific genes within cells

A group of researchers from University of Toronto Engineering and SickKids Hospital have developed a new way to deliver molecules that target specific genes within cells.

4 May 2020

Individuals with high risk of cancer and CVD cannot be identified based on family history

Certain genetic changes, termed "pathogenic variants," substantially increase risk for cardiovascular disease and cancer--the leading causes of death--but testing to identify individual carriers is not part of current clinical practice.

4 May 2020

Study: Unique glucose-sensing neurons in the brain prevent severe hypoglycemia

Low blood sugar levels, known as hypoglycemia, can be a life-threatening situation, especially for people with type 1 diabetes who rely on intensive insulin therapy to prevent blood sugar from going too high.

4 May 2020

Scripps professor receives Research Program Award for advancing RNA-targeting medicines

In recognition of his high-impact work advancing the field of RNA-targeting medicines, the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, has awarded Scripps Research Chemistry Professor Matthew Disney, PhD, a prestigious Research Program Award, to aid Disney's development of treatments for incurable diseases such as Alzheimer's, Parkinson's, ALS and frontotemporal dementia.

4 May 2020

Inventor of hepatitis C cure wins prestigious award from University of Edinburgh

A medicinal chemist who found a cure for the viral disease hepatitis C has received a prestigious award from the University of Edinburgh.

3 May 2020

Study reports cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2

A team of Chinese scientists have reported the high-resolution cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2, the infective virus of COVID-19.

3 May 2020

Genetic News and Research

SARS-CoV-2 genome shows mutation hotspots and type-specific distribution

COVID-19 infection risk and outcomes explained by the cell receptor genetic variability

New therapeutic possibilities for treating intellectual disability in Down syndrome

Study explores maternal infection and its role in neurodevelopmental disorders

Indian physicians’ petition puts focus on race risks in the wake of COVID-19

Researchers discover new gene involved in regulating the body's cholesterol

COVID-19 progression linked to B cell activation

Human endemic coronavirus reinfection possible after recovery

New technology enables visualization of small structures inside whole cells and tissues

Rice scientist wins federal grant for eye research

ASU team identifies new, unique SARS-CoV-2 mutation

Wyss Institute and Cytosurge collaborate to improve CRISPR multiplexing

Scientists develop CRISPR-based test for SARS-CoV-2

Researchers discover hidden symmetry in chemical kinetic equations

Scientists develop new way to deliver molecules that target specific genes within cells

Individuals with high risk of cancer and CVD cannot be identified based on family history

Study: Unique glucose-sensing neurons in the brain prevent severe hypoglycemia

Scripps professor receives Research Program Award for advancing RNA-targeting medicines

Inventor of hepatitis C cure wins prestigious award from University of Edinburgh

Study reports cryo-EM structure of Remdesivir-bound RNA replicase complex from SARS-CoV-2

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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