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Scientists identify treatments that may restore brain function to autism patients

Scientists have identified a pair of treatments that may restore brain function to autism patients who lack a gene critical to maintaining connections between neurons, according to a study from the Peter O'Donnell Jr. Brain Institute at UT Southwestern Medical Center.

1 Nov 2017

Understanding obesity-cancer link to develop effective prevention strategies

In 2012, about 28,000 new cases of cancer in men (3.5%) and 72,000 in women (9.5%) were due to overweight or obesity in the United States alone. There is an urgent need for research that focuses on the cancer-promoting effects of obesity as it's the leading preventable cause of cancer for women and the second for men.

1 Nov 2017

GW-led network will receive NIH grant to follow children with autism transition into adulthood

A George Washington University-led national collaborative network aimed at improving outcomes for children diagnosed with autism spectrum disorder (ASD) will receive more than $11.7 million from the National Institutes of Health over the next five years to help propel innovative research in the field.

1 Nov 2017

Researchers show how changes along lining of mammary ducts can lead to breast cancer

Breast cancer researchers have mapped early genetic alterations in normal-looking cells at various distances from primary tumors to show how changes along the lining of mammary ducts can lead to disease.

1 Nov 2017

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

The investigational PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) that had BRCA mutations and also those that did not have BRCA mutations but had other alterations in DNA damage-repair pathways.

1 Nov 2017

Starving childhood brain tumor of amino acid could improve effect of chemotherapy, study shows

Starving a childhood brain tumor of the amino acid glutamine could improve the effect of chemotherapy, according to an early study led by Queen Mary University of London and funded by Children with Cancer UK and the Medical Research Council.

1 Nov 2017

Scientists make breakthrough by suppressing aflatoxin-producing fungus in groundnut

Scientists at the Donald Danforth Plant Science Center, in St. Louis, MO and their collaborators at the International Crops Research Institute for the Semi-Arid Tropics in Hyderabad, India, United States Department of Agriculture and Louisiana State University have made a significant research breakthrough by suppressing the aflatoxin-producing fungus in groundnut.

1 Nov 2017

Non-invasive diagnostic tool developed for early detection of ovarian cancer

Investigators from Brigham and Women's Hospital and Dana-Farber Cancer Institute are leveraging the power of artificial intelligence to develop a new technique to detect ovarian cancer early and accurately.

31 Oct 2017

Our chromosomes also wrinkle with age, research shows

Grey hair, wisdom, and wrinkles on our skin mark us as we age, but it's the more subtle changes beneath the surface that make us old. Now, researchers have discovered that our chromosomes also wrinkle with age, changing how our immune system renews itself.

31 Oct 2017

Study shows effects of prenatal BPA exposure at low levels in developing rodent brain

New research from North Carolina State University reveals that prenatal exposure to bisphenol A (BPA) at levels below those currently considered safe for humans affects gene expression related to sexual differentiation and neurodevelopment in the developing rat brain.

31 Oct 2017

Powerful toolkit uncovers rare tumor suppressor genes

A new statistical model has enabled researchers to pinpoint 27 novel genes thought to prevent cancer from forming, in an analysis of over 2000 tumors across 12 human cancer types. The findings could help create new cancer treatments that target these genes, and open up other avenues of cancer research.

31 Oct 2017

Researchers investigate how component of soy may suppress breast cancer development

A University of Arizona Cancer Center research team is engaged in a series of studies to investigate how genistein, a component of soy foods, might suppress the development of breast cancer.

31 Oct 2017

Continued Paracetamol exposure during pregnancy linked to ADHD in offspring

A new study has found that long term or continued use of acetaminophen or paracetamol during pregnancy is linked to a doubled risk of attention-deficit hyperactivity disorder (ADHD) in children. The study entitled, “Prenatal Exposure to Acetaminophen and Risk of ADHD” was published in the latest issue of the journal Pediatrics.

30 Oct 2017

Study reveals unique molecules in the blood of people with MS

A breakthrough study led by the University of Sydney's Brain and Mind Centre and Royal Prince Alfred Hospital has revealed unique molecules in the blood of people with Multiple Sclerosis (MS) that could become definitive diagnostic biomarkers of the world's most common neurologic disability in young adults.

30 Oct 2017

New gene drive approach helps pinpoint combination therapies against fungal pathogens

Candida albicans is a notorious human fungal pathogen that causes thrush and serious systemic infections. Opportunistic C. albicans fungi, which often live inconspicuously in the normal flora of human skin and gut, can switch from their harmless stealth mode to become aggressive pathogens, especially in people whose immune systems are already compromised by pre-existing diseases or harsh drug therapies.

30 Oct 2017

Researchers identify important mechanism of epigenetic gene regulation

How can defective gene activity, which can ultimately lead to cancer, be avoided? Researchers at the University of Zurich have now identified a mechanism how cells pass on the regulation of genetic information through epigenetic modifications. These insights open the door to new approaches for future cancer treatments.

30 Oct 2017

UC study reveals metamorphic adaptation of certain spadefoot toads in response to climate change

Deep within aquatic ecosystems all over the world, certain toad species have managed to survive warmer and drier climate change. But the method behind their metamorphic adaptation to environmental change over time has long puzzled scientists -- until now.

28 Oct 2017

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Several patients with recurring glioblastoma, a deadly brain cancer, survived for more than a year in a clinical trial believed to be the first to use comprehensive DNA and RNA sequencing of a patient's tumor to inform treatment for these patients in real-time.

27 Oct 2017

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

In many metastasized types of cancer, disseminated tumors grow back despite successful chemotherapy. As a research team under the direction of the University of Bern, Switzerland, has now discovered, this is because of isolated cancer cells that survive the chemotherapy due to a phase of dormancy.

27 Oct 2017

Research advance may lead to preservation of hearing in people with Usher syndrome type III

A research advance co-led by Case Western Reserve University School of Medicine's Kumar Alagramam, PhD, may stop the progression of hearing loss and lead to significant preservation of hearing in people with Usher syndrome type III, a form of hereditary hearing loss linked to defects in the sensory "hair" cells in the inner ear. USH3 is caused by a mutation in the clarin-1 gene.

26 Oct 2017

Genes News and Research

Scientists identify treatments that may restore brain function to autism patients

Understanding obesity-cancer link to develop effective prevention strategies

GW-led network will receive NIH grant to follow children with autism transition into adulthood

Researchers show how changes along lining of mammary ducts can lead to breast cancer

PARP inhibitors may have efficacy in selected TNBC patients outside of germline BRCA mutation

Starving childhood brain tumor of amino acid could improve effect of chemotherapy, study shows

Scientists make breakthrough by suppressing aflatoxin-producing fungus in groundnut

Non-invasive diagnostic tool developed for early detection of ovarian cancer

Our chromosomes also wrinkle with age, research shows

Study shows effects of prenatal BPA exposure at low levels in developing rodent brain

Powerful toolkit uncovers rare tumor suppressor genes

Researchers investigate how component of soy may suppress breast cancer development

Continued Paracetamol exposure during pregnancy linked to ADHD in offspring

Study reveals unique molecules in the blood of people with MS

New gene drive approach helps pinpoint combination therapies against fungal pathogens

Researchers identify important mechanism of epigenetic gene regulation

UC study reveals metamorphic adaptation of certain spadefoot toads in response to climate change

Genome-wide molecular tests can guide treatment in recurrent glioblastoma, study shows

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

Research advance may lead to preservation of hearing in people with Usher syndrome type III

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