Mouse Model News and Research

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Neutralizing activity of skin-patch delivered subunit vaccine against SARS-CoV-2 variants

A new study involved an analysis of the serum from a previous study to determine neutralizing activity against new variants.

20 Jul 2022

Future SARS-CoV-2 vaccines could hijack commensal bacteria in the gut–lung axis to confer immunity

Researchers screened bacterial mucosal vaccine vectors from 2015 to the present to identify a promising candidate to present SARS-CoV-2 spike protein or its fragments.

18 Jul 2022

Men with hematopoietic mosaic loss of Y chromosome have worse prognosis for heart failure

research group led by Dr. Soichi Sano, a specially appointed lecturer in the Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka Metropolitan University, revealed that men with hematopoietic mosaic loss of Y chromosome (mLOY) — meaning men with an increase, in the blood, of cells that have lost the male sex chromosome — have a worse prognosis for heart failure due to fibrosis progression in the heart.

15 Jul 2022

New mouse model faithfully mimics brain damage caused by severe Rift Valley Fever virus infection

A new mouse model identified by virologists from the University of Pittsburgh might revolutionize development of therapies targeting brain inflammation caused by Rift Valley Fever virus (RVFV).

15 Jul 2022

Mosaic loss of Y chromosome increases risk for heart failure and cardiac fibrosis in men

Why a condition that frequently occurs in aging men, in which an increasing number of hematopoietic cells display a loss of the Y chromosome, is associated with increased risk of mortality and age-related diseases is now a little clearer, thanks to work in mice.

15 Jul 2022

Y chromosome loss in men can lead to deadly heart failure, research shows

The loss of the male sex chromosome as many men age causes the heart muscle to scar and can lead to deadly heart failure, new research from the University of Virginia School of Medicine shows.

14 Jul 2022

MINAR2 gene mutations cause progressive hearing loss

Researchers at the John T. Macdonald Department of Human Genetics and the John P. Hussman Institute for Human Genomics at the University of Miami Miller School of Medicine have found that inherited mutations in the MINAR2 gene caused deafness in four families. The gene variation mostly affects the inner ear hair cells, which are critical to hearing.

14 Jul 2022

Constant activation of p53 in hepatocytes of CLD patients could promote the development of liver cancer

p53 is one of the most important proteins in cancer biology. Often referred to as a "guardian of the genome," p53 becomes activated in response to various cellular stressors like DNA damage.

12 Jul 2022

Experimental model reveals possible causes and treatments for long-COVID

In a recent study published in the journal Science Translational Medicine, researchers characterized long-term pulmonary consequences of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) mouse-adapted strain (MA10) infection in BALB/c laboratory mice.

11 Jul 2022

Study finds microglia to be responsible for neuronal death in a mitochondrial disease animal model

Microglia, a type of central nervous system cell, is primarily responsible for neuronal death in Leigh Syndrome and the neurological symptoms related to this mitochondrial disease.

8 Jul 2022

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

A recent study reported that long COVID in mice causes brain inflammation and cognitive impairment.

8 Jul 2022

IMBA researchers uncover basic principles of early development using blastoids

One often thinks that the early embryo is fragile and needs support. However, at the earliest stages of development, it has the power to feed the future placenta and instructs the uterus so that it can nest.

7 Jul 2022

Study determines how the emotional hub of the brain contributes to negative feelings

Tucked into the temporal lobe, near the base of our brain, sits a small, almond-shaped region called the amygdala that processes our emotions.

7 Jul 2022

Researchers find a way to kill recurring prostate cancer with a lot of iron

Prostate cancer can come back from common hormone deprivation therapy with a vengeance and no clear treatment option, but scientists have early evidence that one way to kill these recurring cancer cells may be with a lot of iron.

7 Jul 2022

DZNE and Intravacc receive € 2.5 million EU funding to develop a prototype ALS vaccine

DZNE and Intravacc B.V., a world leading contract development and manufacturing organization (CDMO) of preventive and therapeutic vaccines, have been awarded a funding of € 2.5 million from the European Union (EIC Transition Grant) to further develop a prototype ALS vaccine, including process development, scale-up, and toxicology study.

6 Jul 2022

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

The Damon Runyon Cancer Research Foundation has named five new Damon Runyon Clinical Investigators.

6 Jul 2022

Gene defect underlying Krabbe disease causes degeneration of neurons directly, study finds

The gene defect underlying Krabbe disease causes degeneration of neurons directly, independent of its effects on other cell types, according to a new study publishing July 5th in the open-access journal PLOS Biology by Daesung Shin of the University at Buffalo, U.S. and colleagues.

5 Jul 2022

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

The viral replication cycle is crucial for a virus to spread inside the body and cause disease. Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) polymerases.

4 Jul 2022

Scientists prove the “neuroprotective” function of p62 protein in a mouse model

Neurodegenerative diseases like Alzheimer’s and Parkinson’s are defined by pathogenic accumulation of toxic proteins in the brain.

1 Jul 2022

New signaling molecule may offer a therapeutic treatment for common form of hair loss

University of California, Irvine-led researchers have discovered that a signaling molecule called SCUBE3 potently stimulates hair growth and may offer a therapeutic treatment for androgenetic alopecia, a common form of hair loss in both women and men.

30 Jun 2022

Mouse Model News and Research

Neutralizing activity of skin-patch delivered subunit vaccine against SARS-CoV-2 variants

Future SARS-CoV-2 vaccines could hijack commensal bacteria in the gut–lung axis to confer immunity

Men with hematopoietic mosaic loss of Y chromosome have worse prognosis for heart failure

New mouse model faithfully mimics brain damage caused by severe Rift Valley Fever virus infection

Mosaic loss of Y chromosome increases risk for heart failure and cardiac fibrosis in men

Y chromosome loss in men can lead to deadly heart failure, research shows

MINAR2 gene mutations cause progressive hearing loss

Constant activation of p53 in hepatocytes of CLD patients could promote the development of liver cancer

Experimental model reveals possible causes and treatments for long-COVID

Study finds microglia to be responsible for neuronal death in a mitochondrial disease animal model

Characterization of longer-term effects on behavior and brain inflammation following recovery from mild COVID-19

IMBA researchers uncover basic principles of early development using blastoids

Study determines how the emotional hub of the brain contributes to negative feelings

Researchers find a way to kill recurring prostate cancer with a lot of iron

DZNE and Intravacc receive € 2.5 million EU funding to develop a prototype ALS vaccine

Damon Runyon Cancer Research Foundation names five new Damon Runyon Clinical Investigators

Gene defect underlying Krabbe disease causes degeneration of neurons directly, study finds

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

Scientists prove the “neuroprotective” function of p62 protein in a mouse model

New signaling molecule may offer a therapeutic treatment for common form of hair loss

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