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Two new research papers reveal how breast cancer cells avoid anoikis

Two new papers from the lab of Zach Schafer, Coleman Assistant Professor of Cancer Biology at the University of Notre Dame, offer insights into how breast cancer cells avoid anoikis, which is cell death induced by detachment from the extracellular matrix (ECM).

21 Apr 2015

Ibrutinib (IMBRUVICA) may be effective for pancreatic ductal adenocarcinoma

Ibrutinib (IMBRUVICA) data presented yesterday by Pharmacyclics, Inc. at the American Association for Cancer Research Annual Meeting suggest that ibrutinib may be an effective therapeutic option for pancreatic ductal adenocarcinoma (PDAC), as shown in both a transgenic mouse model and an in-vivo model of patient-derived xenograft (PDX) mice (grafts of tissue taken from a pancreatic cancer patient and grafted into a mouse).

20 Apr 2015

UNM Cancer Center enrolls first patient in phase 3 international clinical trial for kidney cancer vaccine

The University of New Mexico Cancer Center recently enrolled its first patient in a phase 3 international clinical trial to test a personalized vaccine against metastatic kidney cancer. Kidney cancer has proven particularly difficult to treat with chemotherapy, and numerous attempts to create a kidney cancer vaccine have not improved survival rates.

20 Apr 2015

Can-Fite seeks EMA Orphan Drug Designation for CF102 in HCC

Can-Fite BioPharma Ltd., a biotechnology company with a pipeline of proprietary small molecule drugs that are being developed to treat inflammatory diseases, cancer and sexual dysfunction, announced today it has submitted an application to the European Medicines Agency for Orphan Drug Designation for its drug candidate CF102 in the treatment of hepatocellular carcinoma (HCC), the most common form of liver cancer.

20 Apr 2015

PCF announces Stupski Prize in Prostate Cancer Computational Oncology

The Prostate Cancer Foundation is pleased to announce the Stupski Prize in Prostate Cancer Computational Oncology, a first-in-field initiative designed to attract novel ideas to the rapidly changing field of large-scale cancer bioinformatics.

20 Apr 2015

CAP pathologist shares four tips for women with breast cancer

For any woman, a diagnosis of breast cancer can be frightening. But as Rita Wilson's recent experience shows, engaging with the keystone of the diagnosis - the pathology report - can be critical in achieving good outcomes. Informed by rigorous scientific processes, training and team discussion, pathology reports identify a diagnosis, help indicate the right providers for a patient's care team and shape treatment plans.

20 Apr 2015

Research explores new, personalized ovarian cancer treatments

Identifying molecular changes that occur in tissue after chemotherapy could be crucial in advancing treatments for ovarian cancer, according to research from Magee-Womens Research Institute and Foundation and the University of Pittsburgh Cancer Institute, partner with UPMC CancerCenter, presented today at the American Association for Cancer Research Annual Meeting 2015.

20 Apr 2015

Pembrolizumab drug halts tumor growth in 76% of patients with pleural mesothelioma

The PD-1 inhibitor pembrolizumab, a cancer immunotherapy drug, shrank or halted growth of tumors in 76 percent of patients with pleural mesothelioma, a rare and deadly form of cancer that arises in the outer lining of the lungs and internal chest wall, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

20 Apr 2015

Penn professor to be recognized with AACR-CRI Lloyd J. Old Award in Cancer Immunology

The American Association for Cancer Research and the Cancer Research Institute will recognize Carl H. June, MD, the Richard W. Vague professor in immunotherapy at the Perelman School of Medicine and director of the Center for Cellular Immunotherapies at the University of Pennsylvania in Philadelphia, with the third annual AACR-CRI Lloyd J. Old Award in Cancer Immunology at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

20 Apr 2015

Paradigm to provide PCDx test to oncologists in TD2 networks

Paradigm and Translational Drug Development today announced a partnership under which Paradigm will provide their PCDx test to TD2's affiliated oncology provider networks.

20 Apr 2015

New book can change the way cancer is detected

Jenny Hrbacek's new book, Cancer Free! Are You SURE? can play a role in changing the way cancer is detected. It contains lifesaving information. Far too many people – and she was one of them – get a diagnosis out of the blue and are whisked to the operating table or chemotherapy chair in a matter of days.

17 Apr 2015

Study points to potential therapeutic targets to halt tumor cell movement

Tumor cells become lethal when they spread. Blocking this process can be a powerful way to stop cancer. Historically, scientists thought that tumor cells migrated by brute force, actively pushing through whatever tissue was in their way, but recent evidence has shown that tumor cells may be more methodical. And in a new study, Cornell University researchers report that tumor cells take advantage of already-cleared paths to migrate unimpeded

17 Apr 2015

James Allison to be honored with 2015 Pezcoller Foundation-AACR International Award for Cancer Research

The 2015 Pezcoller Foundation-American Association for Cancer Research (AACR) International Award for Cancer Research will be presented to James P. Allison, PhD, at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

17 Apr 2015

Donald S. Coffey to receive Margaret Foti Award at AACR Annual Meeting 2015

Donald S. Coffey, PhD, will be honored with the ninth annual American Association for Cancer Research Margaret Foti Award for Leadership and Extraordinary Achievements in Cancer Research at the AACR Annual Meeting 2015, to be held in Philadelphia, April 18-22.

17 Apr 2015

New method for measuring genetic variability may help identify patients with aggressive cancers

A new method for measuring genetic variability within a tumor might one day help doctors identify patients with aggressive cancers that are more likely to resist therapy, according to a study led by researchers now at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

17 Apr 2015

Patterns of DNA anomalies can predict outcomes in women with ovarian cancer

Nearly anyone touched by ovarian cancer will tell you: it's devastating. It's bad enough that cancer in almost 80 percent of patients reaches advanced stages before diagnosis, and that most patients are expected to die within five years. But just as painfully, roughly one quarter of women diagnosed have no warning that they are resistant to platinum-based chemotherapy, the main line of defense, nor that they will likely have 18 months to live.

16 Apr 2015

UAB research findings may lead to better treatment for women with HER2+ breast cancer

There are five subtypes of breast cancer, and they are distinct diseases with vastly different biologies that drastically alter their progression and responses to treatment. Understanding those differences is the starting point to a more effective, personalized treatment of breast cancer, which strikes more than 230,000 women in the U.S. each year.

16 Apr 2015

Yale University launches clinical study to evaluate personalized medicine for metastatic melanoma

Yale University has launched a multicenter clinical trial, sponsored by Stand Up to Cancer and Melanoma Research Alliance, that will apply the latest in personalized medicine technology to treat metastatic melanoma. The trial, for which Yale is a lead site, will enroll patients lacking a particular genetic mutation for whom immune therapy did not work or was not an option.

16 Apr 2015

Houston Methodist researchers discover new, ex vivo lung cancer model to study tumor progression

Without good models to study cancer metastasis -- the spread of cancer cells from one organ to another -- cancer researchers have struggled to understand tumor progression fully, and new therapies targeting the main causes of death are slow to come.

16 Apr 2015

Changes in JAK/STAT3 cell signaling pathway drive ALK-negative ALCL

The first-ever systematic study of the genomes of patients with ALK-negative anaplastic large cell lymphoma (ALCL), a particularly aggressive form of non-Hodgkin's lymphoma, shows that many cases of the disease are driven by alterations in the JAK/STAT3 cell signaling pathway.

15 Apr 2015

Tumor News and Research

Two new research papers reveal how breast cancer cells avoid anoikis

Ibrutinib (IMBRUVICA) may be effective for pancreatic ductal adenocarcinoma

UNM Cancer Center enrolls first patient in phase 3 international clinical trial for kidney cancer vaccine

Can-Fite seeks EMA Orphan Drug Designation for CF102 in HCC

PCF announces Stupski Prize in Prostate Cancer Computational Oncology

CAP pathologist shares four tips for women with breast cancer

Research explores new, personalized ovarian cancer treatments

Pembrolizumab drug halts tumor growth in 76% of patients with pleural mesothelioma

Penn professor to be recognized with AACR-CRI Lloyd J. Old Award in Cancer Immunology

Paradigm to provide PCDx test to oncologists in TD2 networks

New book can change the way cancer is detected

Study points to potential therapeutic targets to halt tumor cell movement

James Allison to be honored with 2015 Pezcoller Foundation-AACR International Award for Cancer Research

Donald S. Coffey to receive Margaret Foti Award at AACR Annual Meeting 2015

New method for measuring genetic variability may help identify patients with aggressive cancers

Patterns of DNA anomalies can predict outcomes in women with ovarian cancer

UAB research findings may lead to better treatment for women with HER2+ breast cancer

Yale University launches clinical study to evaluate personalized medicine for metastatic melanoma

Houston Methodist researchers discover new, ex vivo lung cancer model to study tumor progression

Changes in JAK/STAT3 cell signaling pathway drive ALK-negative ALCL

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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