Birth Defects News and Research

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Impact of birth defects on families and nation

Two separate government reports highlight the economic costs of birth defects, focusing attention on the ongoing need for prevention.

22 Jan 2007

Stem cells derived from human amniotic fluid appear to offer many of the benefits of embryonic stem cells

...including the ability to grow into brain, muscle, bone and other tissues -- according to a study published in the Jan. 7 online edition on the journal Nature Biotechnology, the Washington Post reports.

9 Jan 2007

One-third of infant deaths occur in prem babies

Almost twice as many infant deaths than previously estimated, are because babies are born prematurely.

2 Oct 2006

SUMO1 gene implicated in cleft lip and palate defects

Researchers supported by the National Institutes of Health report in the current issue of the journal Science that a much-studied gene called SUMO1, when under expressed, can cause cleft lip and palate, one of the world's most common birth defects.

21 Sep 2006

Preconception care for improving perinatal outcomes: The time to act

Continued improvements in the infant and maternal mortality rates will depend on interventions before a woman becomes pregnant, according to officials from the March of Dimes, the U.S. Centers for Disease Control and Prevention and other experts.

19 Sep 2006

Accutane iPledge program requirements leading to illegal online sales

The strict regulations governing the prescription and use of the acne drug isotretinoin, sold by Roche under the brand name Accutane, are affecting the drug's sale and dispensation and raising concerns about sales of the medication over the Internet, the Wall Street Journal reports (Corbett Dooren, Wall Street Journal, 9/12).

13 Sep 2006

Some find Accutane iPledge program requirements burdensome

Six months after the introduction of iPledge -- with which all people taking the acne drug isotretinoin, sold by Roche under the brand name Accutane, must register to receive their prescriptions - many patients and dermatologists "complain that the rules of iPledge are onerous and unworkable

5 Sep 2006

Prenatal diagnostic tests have low risk of miscarriage

Pregnant women who seek prenatal diagnostic testing to identify genetic or chromosomal abnormalities have a lower risk of miscarriage than previously believed, according to a UCSF study.

31 Aug 2006

90% of dermatologists report having problems with Isotretinoin drug registry

The online FDA tracking database iPledge -- with which all people taking the acne drug isotretinoin, sold by Roche under the brand name Accutane, must register to receive their prescriptions -- has caused problems for about 90% of dermatologists.

30 Aug 2006

A close look at Accutane drug registry iPledge

The Chicago Sun-Times on Monday examined the online FDA tracking database iPledge, with which all people taking Roche's acne drug Accutane much register to receive their prescriptions (Ritter, Chicago Sun-Times, 8/21).

24 Aug 2006

Researchers discover how genes and diet interact to cause birth defects

Expectant mothers may someday get a personalized menu of foods to eat during pregnancy to complement their genetic makeup as a result of new research at Washington University School of Medicine in St. Louis.

8 Aug 2006

Atp7a determines a hierarchy of copper metabolism essential for notochord development

A new study reveals the timing of developmental events that critically depend on copper. While copper deficiency is rare in humans, the findings suggest that suboptimal copper metabolism might contribute to birth defects, according to the researchers.

8 Aug 2006

Valproate poses high risk for fetal death and birth defects

The epilepsy drug valproate poses a higher risk for fetal death and birth defects than other commonly used epilepsy drugs, according to a study published in the August 8, 2006, issue of Neurology.

8 Aug 2006

Researchers have found that increasing paternal age is significantly associated with increased rates of spontaneous abortion

Results indicate that as the male partner ages there is a steady increase in rate of miscarriage.

3 Aug 2006

EPA accused of putting industry interests before public health

The U.S. Environmental Protection Agency (EPA) is being put under pressure by a number of states to be transparent, especially when it comes to insisting pesticide manufacturers disclose all the ingredients on their product labels.

2 Aug 2006

New insights into how cells repair damaged DNA

Cancer researchers have discovered that a recently identified protein critical for repairing damaged genes uses an unusual mechanism to keep its repairs accurate.

26 Jul 2006

Discovery could help identify genes that cause human heart defects

Researchers at UT Southwestern Medical Center have identified a group of fruit fly gene mutations responsible for "broken hearts" in the embryonic stages of development, a discovery that could help identify genes that cause human heart defects.

25 Jul 2006

Latest sequencing targets for NHGRI

The National Human Genome Research Institute (NHGRI) has announced several new sequencing targets including the Northern white-cheeked gibbon (Nomascus leucogenys).

19 Jul 2006

Obese women at greater risk of disease and death

Experts say that obesity is a disease that now affects nearly one-third of the adult American population, approximately 60 million people, and the latest study on the condition suggests that health risks to women who are obese may have been underestimated.

6 Jul 2006

Popular hypertension drugs triple the risk of birth defects

A study by American researchers has found that certain widely used hypertension drugs, once considered safe in the early stages of pregnancy, can almost triple the risk of birth defects.

8 Jun 2006