Signaling Pathway News and Research

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Skin cells derived from autistic donors grow faster than those from control subjects

Brain cells grow faster in children with some forms of autism due to distinct changes in core cell signaling patterns, according to research from the laboratory of Anthony Wynshaw-Boris, MD, PhD, chair of the department of genetics and genome sciences at Case Western Reserve University School of Medicine.

28 Aug 2016

German scientists develop new approach to prevent GvHD after bone marrow transplants

Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft-versus-host disease (GvHD) after therapeutic bone marrow transplants.

16 Aug 2016

Scientists discover key molecule that drives regeneration in planarian stem cells

Many living creatures possess exceptional abilities that set them apart from other species. Cheetahs can run up to 60 miles per hour; ants can lift 100 times their body weight; flatworms can regrow amputated body parts.

12 Aug 2016

Whitehead Institute researchers identify cellular mechanisms involved in pre-mouth array formation

Whitehead Institute researchers have identified the pre-mouth array--an area of the developing face in embryonic frogs--that "unzips" to surround the mouth opening. Their work highlights the precision necessary to create the mouth and identifies the cellular mechanisms that drive its formation.

9 Aug 2016

Wistar scientists discover novel mechanism that helps tumors adapt to hypoxia

One of the many reasons tumors are so difficult to treat is that they are able to adapt whenever they are exposed to unfavorable conditions.

9 Aug 2016

Alcohol-craving rats offer insights into genetic underpinnings of alcoholism

Alcohol-craving rats have provided researchers with a detailed look into the complicated genetic underpinnings of alcoholism.

5 Aug 2016

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

A Brazilian study shows that inhibition of an RNA named RMEL3, which is encoded by a previously uncharacterized gene (also named RMEL3), can reduce the viability of cultured melanoma cells by up to 95%.

4 Aug 2016

New drug treatment could reduce body weight in obese patients with rare genetic disorder

As part of a phase II study at Charité - Universitätsmedizin Berlin and the Berlin Institute of Health, two obese patients with a rare genetic disorder were given a drug treatment to stimulate the satiety center in the brain.

3 Aug 2016

Scientists use Regeneration Intelligence to assess perturbation status of many signaling pathways

Insilico Medicine, Inc in collaboration with scientists from Atlas Regeneration, Inc, Vision Genomics, Inc and Howard University published two research papers on fibrosis in the lung and liver and fibrotic signatures in glaucoma.

30 Jul 2016

Blood pressure hormone system important for cardiovascular health can promote obesity

New research by University of Iowa scientists helps explain how a hormone system often targeted to treat cardiovascular disease can also lower metabolism and promote obesity.

29 Jul 2016

Adding new monoclonal antibody to chemotherapy improves survival in soft-tissue sarcoma patients

Adding a novel monoclonal antibody therapy to traditional chemotherapy increased median survival by nearly a year in patients with advanced sarcoma, a lethal soft-tissue cancer.

21 Jul 2016

Immune system signaling can directly affect social behavior

Using a systems-biology approach, scientists at the University of Massachusetts Medical School made a startling discovery that immune system signaling can directly affect, and even change, social behavior in mice and other model animals.

18 Jul 2016

TUM scientists discover molecular signaling pathway for self-destruction in leukemia cells

When adults develop blood cancer, they are frequently diagnosed with what is referred to as acute myeloid leukemia.

15 Jul 2016

Expanding the potential of existing cancer therapies: an interview with Dr Mark Rutstein

Cancer remains a leading cause of death worldwide, and the global cancer burden is expected to increase by 70 percent over the next two decades.

14 Jul 2016

Food additive tBHQ may be linked to increase in food allergies

A Michigan State University researcher has found that a common food additive may be linked to a rise in food allergies.

11 Jul 2016

Transplant drug rapamycin may reduce nerve damage, neuropathic pain after spinal cord injury

New research in mice indicates that a drug commonly used to suppress the immune system in recipients of organ transplants may also reduce tissue damage and neuropathic pain after spinal cord injury. The findings are published in the Journal of Orthopaedic Research.

8 Jul 2016

Signaling Pathway News and Research

Skin cells derived from autistic donors grow faster than those from control subjects

German scientists develop new approach to prevent GvHD after bone marrow transplants

Scientists discover key molecule that drives regeneration in planarian stem cells

Whitehead Institute researchers identify cellular mechanisms involved in pre-mouth array formation

Wistar scientists discover novel mechanism that helps tumors adapt to hypoxia

Alcohol-craving rats offer insights into genetic underpinnings of alcoholism

Brazilian study discovers promising therapeutic and diagnostic target for treatment of melanoma

New drug treatment could reduce body weight in obese patients with rare genetic disorder

Scientists use Regeneration Intelligence to assess perturbation status of many signaling pathways

Blood pressure hormone system important for cardiovascular health can promote obesity

Adding new monoclonal antibody to chemotherapy improves survival in soft-tissue sarcoma patients

Immune system signaling can directly affect social behavior

TUM scientists discover molecular signaling pathway for self-destruction in leukemia cells

Expanding the potential of existing cancer therapies: an interview with Dr Mark Rutstein

Food additive tBHQ may be linked to increase in food allergies

Transplant drug rapamycin may reduce nerve damage, neuropathic pain after spinal cord injury

Study identifies genetic mutations responsible for development of cardiac hypertrophy in adults

Study proves cells can send ephrins and Ephs out to transmit signals

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Study links proteins involved in cell division to insulin signaling

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