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Crucial ingredient from University of Kansas included in authorized COVID-19 drug

When the Food and Drug Administration issued an emergency-use authorization for the investigational pharmaceutical remdesivir to treat COVID-19 on May 1, in part it was due to pioneering work performed by pharmaceutical chemists at the University of Kansas School of Pharmacy in 1990.

1 Jun 2020

COVID-19 pandemic has worsened pre-existing mental health conditions

With over 6.26 million cases and 375,000 deaths in just five months, the COVID-19 pandemic has caused great fear and devastation in many parts of the world. Many studies show that, generally, there has been an accompanying increase in fear, anxiety, and depressive symptoms during this period. Now, a new study published on the online preprint server medRxiv in May 2020 shows that patients with a history of mental ill-health often underwent a worsening of their symptoms with the onset of the pandemic.

1 Jun 2020

Study resolves contradictions surrounding p53 gene's role in pluripotent stem cell differentiation

The gene p53 is extremely important in cell biology and, hence, the world of cell replacement therapy. Its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the "tumor suppressor gene."

1 Jun 2020

Update on PALLAS triaI evaluating adjuvant palbociclib for early breast cancer

The Austrian Breast & Colorectal Cancer Study Group, Alliance Foundation Trials, the Breast International Group, PrECOG, LLC, the German Breast Group, and the NSABP Foundation today announced that the independent Data Monitoring Committee for the global Phase 3 early breast cancer PALbociclib CoLlaborative Adjuvant Study trial determined that the study is unlikely to show a statistically significant improvement in the primary endpoint of invasive disease-free survival following a preplanned interim analysis.

1 Jun 2020

Cancer clusters' resistance to natural killer cell immunosurveillance favors metastasis

Scientific evidence suggests that cancer can metastasize to other organs when either a single cell or a cluster of cells detaches from the original tumor and travels through the blood to another location, where it grows into a new tumor.

1 Jun 2020

Reducing inflammation improves stroke recovery, may extend window for therapy

Reperfusion therapy, the gold standard for stroke treatment, helps restore blood flow after a stroke caused by a clot, preventing loss of brain tissue. However, only about 10% of stroke patients qualify, in part because of reperfusion therapy's narrow treatment window.

1 Jun 2020

Studies call for reforms to improve nutritional programs in HIV care settings

HIV management in developing countries varies with socioeconomic and structural circumstances, with two Flinders University studies finding examples of key ways to close the gap for those worst affected in developing countries.

1 Jun 2020

SDSU researchers aim to develop intervention strategy to prevent LGBTQ youth suicide

Suicide is the second leading cause of death among youth and young adults, behind unintentional injury, with suicide attempts much higher among LGBTQ youth (23% to 45%) than their heterosexual and cisgender peers (5%).

1 Jun 2020

‘Why do we always get hit first?’ Proposed budget cuts target vulnerable Californians

Shirley Madden, 83, relies on a caregiver and her two grown daughters to remain living at home — and not in a nursing home.

1 Jun 2020

Using lung simulators to help tackle COVID-19

COVID-19 is a virus that affects the respiratory system in humans. By using realistic lung simulators, we can understand how this virus affects the lungs.

From neosim AG 1 Jun 2020

Oral antidiabetics improve outcomes in diabetics with colorectal cancer

Bottom Line: Among patients with both colorectal cancer and diabetes in Korea, those who had a high adherence to their oral diabetes medication had a significantly reduced risk of overall mortality compared with those with lower adherence.

1 Jun 2020

Researchers develop new method to measure hydroxychloroquine levels in SLE patients

Researchers at Uppsala University and Uppsala University Hospital have developed a new method to measure levels of the medication hydroxychloroquine in patients with rheumatic disease systemic lupus erythematosus (SLE).

1 Jun 2020

Deep vein clots in critical COVID-19 illness

A new research paper published in the journal JAMA Network Open in May 2020 reports a high incidence of deep vein clots in patients with severe COVID-19 at a single French medical center. This could indicate the need for systematic anticoagulant therapy in these patients as a preventive measure.

31 May 2020

Researchers show how ketamine fights difficult-to-treat depression

The anaesthetic drug ketamine has been shown, in low doses, to have a rapid effect on difficult-to-treat depression.

31 May 2020

Ruxolitinib shows promise in severe COVID-19

An anti-inflammatory drug Ruxolitinib has shown promising results in the treatment of severe coronavirus disease COVID-19. The study titled, “Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial,” was published as a pre-proof for the Journal of Allergy and Clinical Immunology.

31 May 2020

Study compares cediranib plus olaparib and standard of care therapy for platinum-sensitive ovarian cancer

Results of the NRG Oncology phase III clinical trial NRG-GY004 indicated that the addition of the investigational agent cediranib to olaparib and standard platinum-based chemotherapy did not improve progression-free survival (PFS) outcomes for women with platinum-sensitive ovarian cancer; however, activity between the treatments was similar in patients.

30 May 2020

New immunotherapy for metastatic non-small cell lung cancer shows promise in clinical trial

A new type of immunotherapy treatment for metastatic non-small cell lung cancer (NSCLC) is being tested by Missak Haigentz, Jr., MD, medical director of hematology and oncology for Atlantic Health System.

30 May 2020

University of Freiburg receives 30 million euros for excellent research

The German Research Foundation has approved a new proposal for a collaborative research center under the leadership of the Institute for Experimental Cardiovascular Medicine at the University Heart Centre Freiburg · Bad Krozingen.

30 May 2020

Immunotherapy doubles progression-free survival time of patients with advanced bowel cancer

A large international trial involving UCL and University College London Hospitals NHS Foundation Trust (UCLH) has found that pembrolizumab, a form of immunotherapy, more than doubled the 'progression free survival' time of patients with a specific subtype of advanced bowel cancer, when compared with chemotherapy.

30 May 2020

Developing an international consortium to improve clinical decision-making in Hodgkin lymphoma

A harmonization of 'big data' in examining long-term outcomes with contemporary treatment for pediatric and adult Hodgkin lymphoma patients is yielding a new approach to inform future clinical trial design and enhance clinical decision-making.

30 May 2020

Therapy News and Research

Crucial ingredient from University of Kansas included in authorized COVID-19 drug

COVID-19 pandemic has worsened pre-existing mental health conditions

Study resolves contradictions surrounding p53 gene's role in pluripotent stem cell differentiation

Update on PALLAS triaI evaluating adjuvant palbociclib for early breast cancer

Cancer clusters' resistance to natural killer cell immunosurveillance favors metastasis

Reducing inflammation improves stroke recovery, may extend window for therapy

Studies call for reforms to improve nutritional programs in HIV care settings

SDSU researchers aim to develop intervention strategy to prevent LGBTQ youth suicide

‘Why do we always get hit first?’ Proposed budget cuts target vulnerable Californians

Using lung simulators to help tackle COVID-19

Oral antidiabetics improve outcomes in diabetics with colorectal cancer

Researchers develop new method to measure hydroxychloroquine levels in SLE patients

Deep vein clots in critical COVID-19 illness

Researchers show how ketamine fights difficult-to-treat depression

Ruxolitinib shows promise in severe COVID-19

Study compares cediranib plus olaparib and standard of care therapy for platinum-sensitive ovarian cancer

New immunotherapy for metastatic non-small cell lung cancer shows promise in clinical trial

University of Freiburg receives 30 million euros for excellent research

Immunotherapy doubles progression-free survival time of patients with advanced bowel cancer

Developing an international consortium to improve clinical decision-making in Hodgkin lymphoma

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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