Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Metabolite profiling during diagnosis helps identify poor treatment outcomes in ALL

The survival of patients with pediatric acute lymphoblastic leukemia (ALL) has significantly improved in the last several decades. However, novel strategies to identify cases that are likely to respond poorly to treatment are still needed.

24 Oct 2019

Anti-arthritis drug can stop tuberculosis bacillus from infecting blood stem cells

Immunologist Johan Van Weyenbergh (KU Leuven) and his Belgian-Brazilian colleagues have shown that a drug used to fight arthritis also stops the process that allows the tuberculosis bacillus to infect and hijack blood stem cells.

23 Oct 2019

Adding plant-based compound to gene therapy could improve treatment outcomes

Gene therapy has broadened the treatment possibilities for those with immune system deficiencies and blood-based conditions, such as sickle cell anemia and leukemia.

17 Oct 2019

Steroid injections for osteoarthritis more may damage joints

Osteoarthritis (OA), also called degenerative joint disease, is the most common chronic condition of the joints. Since the disease is degenerative, it is the single most common cause of disability among older adults, with about 10 to 15 percent of all adults who are more than 60 years old have some degree of osteoarthritis, with more women affected than men.

15 Oct 2019

UCLA researchers discover new way to eliminate leukemia stem cells

The introduction of the drug imatinib in 2001 revolutionized the treatment of a type of cancer called chronic myelogenous leukemia. In more than 80% of people with CML who received the drug, the disease went into complete remission.

15 Oct 2019

Advances in translational genetics unlocked by Bio-Rad technologies to be presented at ASHG 2019

Scientists will present 24 abstracts and three talks, highlighting research driven in part by Bio-Rad Laboratories' Droplet Digital PCR and single-cell ATAC-Seq (scATAC-Seq) technologies, at the 2019 American Society of Human Genetics Annual Meeting in Houston, October 15-19.

15 Oct 2019

Combination of two drugs disrupts cancer cells' ability to survive DNA damage, study finds

In continuing efforts to find novel ways to kill cancer cells, researchers at the University of Maryland School of Medicine have identified a new pathway that leads to the destruction of cancer cells.

14 Oct 2019

$RESILIENT study tests benefit of ETA guided treatments for patients with advanced refractory cancers$

RESILIENT study tests benefit of ETA guided treatments for patients with advanced refractory cancers

RESILIENT was a single arm, open label, phase II/III study to test if label agnostic therapy regimens guided by Encyclopedic Tumor Analysis can offer meaningful clinical benefit for patients with relapsed refractory metastatic malignancies.

11 Oct 2019

Survey quantifies cancer patients' interest in pathology services

Some of the most important players on a cancer patient's health care team are people they typically never meet or interact with - the pathologists who evaluate their tissue samples to determine the type and stage of disease they have.

10 Oct 2019

Lab-grown, testosterone-producing cells could help treat hypogonadism

Researchers have managed to grow human, testosterone-producing cells, which could lead to improved treatment options for low testosterone levels.

9 Oct 2019

New understanding of breast cancer metastasis to bone

In breast cancer patients with metastatic disease, bone is the most common site of metastasis and the most common site of first distant relapse, with roughly half (48%) of breast cancer patients developing bone metastases after treatment.

8 Oct 2019

Viagra enables rapid and efficient hematopoietic stem cell mobilization in mice

The combination of two clinically approved drugs--Viagra and Plerixafor--rapidly and efficiently mobilizes blood stem cells from the bone marrow into the bloodstream in mice, researchers report October 10th in the journal Stem Cell Reports.

4 Oct 2019

Novel viral vector improves gene therapy for sickle cell disease

Researchers at the National Institutes of Health (NIH) have developed a unique, improved lentiviral vector for use in gene therapy for sickle cell disease.

3 Oct 2019

Two cell mutations contribute to the development of acute myeloid leukemia

Sometimes the whole is greater than the sum of its parts. Researchers at Cold Spring Harbor Laboratory have discovered that two cell mutations, already harmful alone, enhance one another's effects, contributing to the development of the deadly blood cancer acute myeloid leukemia (AML).

3 Oct 2019

Researchers make breakthrough in gene therapy for sickle cell disease

Researchers at the National Institutes of Health have developed a new and improved viral vector--a virus-based vehicle that delivers therapeutic genes--for use in gene therapy for sickle cell disease.

2 Oct 2019

New leishmaniasis look-alike parasitic infection reported

A new study published online in the journal Emerging Infectious Diseases describes the appearance of a new protozoan infection carried by insects which causes symptoms that mimic the disease called visceral leishmaniasis, caused by a different parasite.

2 Oct 2019

Review examines the role of biologic agents in management of shoulder and elbow problems

The utilization of stem cell therapies for augmentation of tissue healing has far outpaced the supporting scientific and clinical data, largely due to aggressive marketing that has led to widespread and often inappropriate use of cell therapy approaches in the United States.

1 Oct 2019

Findings could open up new research avenues into how heme tolerance occurs in humans

Most people have some idea of how important iron is to their health, but Iqbal Hamza, professor in Animal and Avian Sciences, has made his seventeen-year career at the University of Maryland all about the study of iron and heme trafficking and regulation in the body.

1 Oct 2019

Study: Transmission of protozoan parasite may cause leishmaniasis-like symptoms in people

A new study published this week online in Emerging Infectious Diseases suggests that transmission of a protozoan parasite from insects may also cause leishmaniasis-like symptoms in people

1 Oct 2019

Detecting neurocognitive change in children with acute lymphoblastic leukemia

Although cure rates for children with cancer are increasing, cancer treatments can cause permanent deterioration of brain functions leading to impairments in attention, concentration, memory and learning. As a result, these changes can lead to challenges with school, obtaining future employment and overall quality of life into adulthood, even though cancer treatment may have been successful.

1 Oct 2019

Bone Marrow News and Research

Further Reading

Metabolite profiling during diagnosis helps identify poor treatment outcomes in ALL

Anti-arthritis drug can stop tuberculosis bacillus from infecting blood stem cells

Adding plant-based compound to gene therapy could improve treatment outcomes

Steroid injections for osteoarthritis more may damage joints

UCLA researchers discover new way to eliminate leukemia stem cells

Advances in translational genetics unlocked by Bio-Rad technologies to be presented at ASHG 2019

Combination of two drugs disrupts cancer cells' ability to survive DNA damage, study finds

RESILIENT study tests benefit of ETA guided treatments for patients with advanced refractory cancers

Survey quantifies cancer patients' interest in pathology services

Lab-grown, testosterone-producing cells could help treat hypogonadism

New understanding of breast cancer metastasis to bone

Viagra enables rapid and efficient hematopoietic stem cell mobilization in mice

Novel viral vector improves gene therapy for sickle cell disease

Two cell mutations contribute to the development of acute myeloid leukemia

Researchers make breakthrough in gene therapy for sickle cell disease

New leishmaniasis look-alike parasitic infection reported

Review examines the role of biologic agents in management of shoulder and elbow problems

Findings could open up new research avenues into how heme tolerance occurs in humans

Study: Transmission of protozoan parasite may cause leishmaniasis-like symptoms in people

Detecting neurocognitive change in children with acute lymphoblastic leukemia

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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