Endocrine News and Research

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LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., today announced detailed results from the Phase III SOLO-1 trial testing LYNPARZA (olaparib) 300 mg tablets twice-daily as a maintenance treatment for patients with newly diagnosed advanced BRCA-mutated ovarian cancer who were in complete or partial response following 1st-line standard platinum-based chemotherapy.

22 Oct 2018

Phase III trial reports positive results with HDAC inhibitor in advanced breast cancer patients

Epigenetic therapy with histone deacetylase inhibitors is worth pursuing in hormone receptor positive advanced breast cancer, suggests a phase III trial reported today at the ESMO 2018 Congress in Munich.

22 Oct 2018

Zoledronic acid increases disease-free survival in premenopausal women with HR+ early breast cancer

Adjuvant treatment with the bone sparing drug zoledronic acid plus hormonal therapy with the aromatase inhibitor letrozole significantly increases disease-free survival compared to tamoxifen in premenopausal women with hormone receptor positive (HR+) early breast cancer, according to results reported at ESMO 2018 Congress in Munich.

22 Oct 2018

Breast cancer survival could be extended with two new drug combinations

A new study has shown that a combination of drugs palbociclib, along with hormone therapy can significantly increase the survival among women with advanced breast cancer.

21 Oct 2018

Study: Children with autism are more likely to be overweight, obese

A new study by researchers at Children's Hospital of Philadelphia (CHOP), the University of Pennsylvania and six other centers reveals that children with developmental delays, including autism spectrum disorder, are up to 50 percent more likely to be overweight or obese compared with the general population.

19 Oct 2018

High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients

Nearly one in six premenopausal women being treated for early stage breast cancer do not adhere adequately to tamoxifen therapy after one year of treatment, potentially putting themselves at increased risk of recurrence and reduced survival, a French prospective study reports at ESMO 2018.

19 Oct 2018

New pragmatic study launched to understand the effectiveness of new type 2 diabetes drug

HealthCore, Inc., the outcomes research subsidiary of Anthem, Inc. and Novo Nordisk Inc., which manufacturers the once weekly GLP-1 receptor agonist Ozempic (semaglutide), are working together to launch the first of its kind pragmatic study to understand the benefits of semaglutide as compared with all other available diabetes drugs in a real-world pragmatic clinical trial for Type 2 diabetes - one of the nation's fastest growing chronic diseases.

17 Oct 2018

Study: Neurons regulating reproductive hormone release have different activity in epileptic mice

Mice with epilepsy have altered patterns of neuron activity in the portion of the brain that controls the reproductive endocrine system, University of Illinois researchers report in a new study. Furthermore, the differences in neuron activity in female mice fluctuate across the reproductive cycle, the team found.

15 Oct 2018

Scientists discover molecular link between body weight and early-onset puberty

Becoming overweight at a young age can trigger a molecular chain reaction that leads some girls to experience puberty early, according to new research published in Nature Communications.

11 Oct 2018

Genentech announces Phase III study results of baloxavir marboxil in people at high risk of flu

Genentech, a member of the Roche Group, today announced that the Phase III CAPSTONE-2 study showed treatment with baloxavir marboxil significantly reduced the time to improvement of influenza symptoms versus placebo in people at high risk of serious complications from the flu, which includes adults 65 years of age or older, or those who have conditions such as asthma, chronic lung disease, morbid obesity, or heart disease.

4 Oct 2018

Single ovary removal for fertility preservation in girls causes no complications

In the first publication from the U.S. on surgical techniques and outcomes of single ovary removal for fertility preservation in girls, surgeons from Ann & Robert H. Lurie Children's Hospital of Chicago report that the procedure caused no complications and can be performed laparoscopically, on an outpatient basis, without delaying treatment for cancer or other therapies posing high risk of infertility.

1 Oct 2018

New approach to causality moves away from temporally linear model of cause and effect

Natural little scientists, human babies love letting go of things and watching them fall. Baby's first experiment teaches them about more than the force of gravity.

29 Sep 2018

Shared decision making needed to diagnose, treat, and manage patients with CAH

The Endocrine Society today issued a Clinical Practice Guideline that offers best practices for healthcare providers on how to promptly diagnose, treat, and manage patients with congenital adrenal hyperplasia, an inherited endocrine disorder, throughout their entire lives.

28 Sep 2018

Rochester and Minnesota team receives grant to create center for child maltreatment studies

The University of Rochester's Mt. Hope Family Center, in conjunction with the University of Minnesota's Institute for Translational Research in Children's Mental Health, has received a multi-million-dollar grant to create a national center for child maltreatment studies, becoming one of only three academic institutional partnerships in the United States to receive this prestigious award from the National Institutes of Health.

28 Sep 2018

Study: PVC-floored homes are source of phthalate uptake in pregnant women

A new study in the SELMA project at Karlstad University, Sweden, shows that plastic flooring in the home are a source of uptake of phthalates in pregnant women, phthalates that are considered dangerous in the EU chemical regulation system.

27 Sep 2018

CPSC forms new committee to take decision whether to ban organohalogens or not

Hundreds of everyday household items, from laptop computers to babies' high chairs, contain flame retardants to prevent the objects from catching fire.

27 Sep 2018

New EU project aims to learn more about hormone-disrupting chemicals

Hormone-disrupting chemicals in our environment can affect early neurodevelopment in children, but little is known about the exact mechanisms for this interference. A new EU funded research project, coordinated from Karolinska Institutet, now aims to learn more and to develop better screening and testing tools.

26 Sep 2018

Endocrine News and Research

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

Phase III trial reports positive results with HDAC inhibitor in advanced breast cancer patients

Zoledronic acid increases disease-free survival in premenopausal women with HR+ early breast cancer

Breast cancer survival could be extended with two new drug combinations

Study: Children with autism are more likely to be overweight, obese

High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients

New pragmatic study launched to understand the effectiveness of new type 2 diabetes drug

Study: Neurons regulating reproductive hormone release have different activity in epileptic mice

Scientists discover molecular link between body weight and early-onset puberty

Genentech announces Phase III study results of baloxavir marboxil in people at high risk of flu

Single ovary removal for fertility preservation in girls causes no complications

New approach to causality moves away from temporally linear model of cause and effect

Shared decision making needed to diagnose, treat, and manage patients with CAH

Rochester and Minnesota team receives grant to create center for child maltreatment studies

Study: PVC-floored homes are source of phthalate uptake in pregnant women

CPSC forms new committee to take decision whether to ban organohalogens or not

New EU project aims to learn more about hormone-disrupting chemicals

New research suggests link between PFAS chemicals and hyperthyroidism in pet cats

UNIST to accelerate discovery, development of new medicines for incurable diseases

FDA-approved 'safe' daily BPA exposure may contribute to insulin resistance

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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