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An algorithm to predict host cleavage targets of SARS-CoV-2 3CLPro

In a recent study posted to the bioRxiv* preprint server, researchers developed a novel bioinformatic algorithm to predict host cleavage targets of the SARS-CoV-2 3C-like protease (3CLPro).

23 Jan 2022

Nirmatrelvir, Molnupiravir, and Remdesivir hold-up against SARS-CoV-2 Omicron variant in vitro

In a recent study posted to the bioRxiv* preprint server, researchers test three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals authorized for emergency use by the United States Food and Drug Administration (FDA) for their in vitro potency against several SARS-CoV-2 variants, including the currently dominant Omicron train.

23 Jan 2022

Genetic marker linked to higher risk of death in COVID-19 patients

A new study discusses the importance of single nucleotide polymorphisms in the Rab46 gene as a marker of adverse outcomes in high-risk COVID-19 patients.

23 Jan 2022

Novel SARS-CoV-2 mutations reported in chronic HIV patients

A new study describes the emergence of new SARS-CoV-2 variants in three immunocompromised patients.

23 Jan 2022

Robust BNT162b2 vaccine-induced B and T-cell immunity against early SARS-CoV-2 variants

Researchers describe the state of adaptive immunity following vaccination with the Pfizer-BioNTech BNT162b2 COVID-19 vaccine.

23 Jan 2022

COVID-19 lockdowns depleted water quality of commercial building plumbing systems

Researchers evaluate how altered water demand in commercial and residential buildings deteriorated the water quality during the COVID-19 pandemic.

23 Jan 2022

Optical imaging reveals how cancer cells hijack metabolic activity to fuel pancreatic tumor growth

Pancreatic cancer is a rare, yet elusive and deadly cancer, with a five-year survival rate of about 10%. If the cancer has metastasized, that rate lowers to 3%. And treatment options are extremely limited.

22 Jan 2022

Study finds more than 1,000 gene-activation differences between female and male mouse brains

Male and female mouse brains differ in important ways, according to a new study led by Stanford Medicine investigators.

22 Jan 2022

Scientists develop new drug delivery system for treating genetic diseases

A team of researchers led by Harvard and Broad Institute scientists has developed a new drug delivery system using engineered DNA-free virus-like particles (eVLPs) to package and deliver therapeutic levels of gene-editing proteins to animal models of disease.

22 Jan 2022

Alphacoronaviruses found to be common in bats in the upper Midwestern United States

In a new study, researchers used a pan-coronavirus PCR to screen bats submitted for rabies testing owing to human exposure in order to find potentially novel bat CoVs that may represent a concern to people.

21 Jan 2022

Researchers develop new biological parts to shape the flow of cellular processes along DNA

Scientists at the University of Bristol have developed new biological parts that are able to shape the flow of cellular processes along DNA.

21 Jan 2022

Scientists identify a new switch for controlling motor proteins

Inside neurons, motor proteins haul precious cargo, moving essential goods along thread-like roadways called microtubule tracks.

21 Jan 2022

Study supports that Omicron variant has shifted to better usage of Cathepsin B/L entry pathway

A new study analyzed new data on the Omicron variant and indicated the altered cell entry pathways compared to other variants.

21 Jan 2022

Single type of neuron found to be responsible for keeping our legs in lockstep

Walking is the most natural of movements. Without thinking, we put one foot forward and then the next, on and on, propelling us forward. So, if we're not consciously directing this complex interplay of nerves and muscles, what is?

21 Jan 2022

Study suggests SARS-CoV-2 Omicron variant spike mediated immune escape and tropism shift

A new study showed that the SARS-CoV-2 Omicron spike binds to its receptor with enhanced affinity and yet evades vaccine-elicited neutralizing antibodies and that a booster mRNA vaccine broadened the neutralization of Omicron.

21 Jan 2022

Fast-tracked ruling on abortion won’t wait for ‘hearts and minds’ to change

When he was running for president in 1999, George W. Bush, then governor of Texas, famously fended off the strong anti-abortion wing of his party by suggesting the country ought not consider banning abortion until public opinion shifted further in that direction. "Laws are changed as minds are persuaded," he said.

21 Jan 2022

Study sheds light on how melanoma primes nearby lymph nodes for tumor metastases

Melanoma cells release small extracellular packages containing the protein nerve growth factor receptor, which primes nearby lymph nodes for tumor metastases, according to a new study by Weill Cornell Medicine investigators.

21 Jan 2022

Cannabidiol found to inhibit SARS-CoV-2 infection in human cells and mice

An interdisciplinary team of researchers from the University of Chicago has found evidence that cannabidiol (CBD), a product of the cannabis plant, can inhibit infection by SARS-CoV-2 in human cells and in mice.

21 Jan 2022

Nano-bubbles containing ACE2 protein can block infection from broad strains of SARS-CoV-2

Scientists at Northwestern Medicine and The University of Texas MD Anderson Cancer Center have identified natural nano-bubbles containing the ACE2 protein (evACE2) in the blood of COVID-19 patients and discovered these nano-sized particles can block infection from broad strains of SARS-CoV-2 virus in preclinical studies.

21 Jan 2022

Hospitalization risk high for IBD patients with incomplete COVID-19 vaccinations

The Crohn's & Colitis Foundation and the American Gastroenterological Association (AGA) are bringing together the inflammatory bowel disease (IBD) care community for the fifth annual Crohn's & Colitis Congress®, taking place virtually Jan. 20 through 22, 2022.

21 Jan 2022

B Cell News and Research

An algorithm to predict host cleavage targets of SARS-CoV-2 3CLPro

Nirmatrelvir, Molnupiravir, and Remdesivir hold-up against SARS-CoV-2 Omicron variant in vitro

Genetic marker linked to higher risk of death in COVID-19 patients

Novel SARS-CoV-2 mutations reported in chronic HIV patients

Robust BNT162b2 vaccine-induced B and T-cell immunity against early SARS-CoV-2 variants

COVID-19 lockdowns depleted water quality of commercial building plumbing systems

Optical imaging reveals how cancer cells hijack metabolic activity to fuel pancreatic tumor growth

Study finds more than 1,000 gene-activation differences between female and male mouse brains

Scientists develop new drug delivery system for treating genetic diseases

Alphacoronaviruses found to be common in bats in the upper Midwestern United States

Researchers develop new biological parts to shape the flow of cellular processes along DNA

Scientists identify a new switch for controlling motor proteins

Study supports that Omicron variant has shifted to better usage of Cathepsin B/L entry pathway

Single type of neuron found to be responsible for keeping our legs in lockstep

Study suggests SARS-CoV-2 Omicron variant spike mediated immune escape and tropism shift

Fast-tracked ruling on abortion won’t wait for ‘hearts and minds’ to change

Study sheds light on how melanoma primes nearby lymph nodes for tumor metastases

Cannabidiol found to inhibit SARS-CoV-2 infection in human cells and mice

Nano-bubbles containing ACE2 protein can block infection from broad strains of SARS-CoV-2

Hospitalization risk high for IBD patients with incomplete COVID-19 vaccinations

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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